DK1572711T3 - Vandfrit krystallinsk azidocytosin-hemisulfatderivat - Google Patents

Vandfrit krystallinsk azidocytosin-hemisulfatderivat

Info

Publication number
DK1572711T3
DK1572711T3 DK03767770T DK03767770T DK1572711T3 DK 1572711 T3 DK1572711 T3 DK 1572711T3 DK 03767770 T DK03767770 T DK 03767770T DK 03767770 T DK03767770 T DK 03767770T DK 1572711 T3 DK1572711 T3 DK 1572711T3
Authority
DK
Denmark
Prior art keywords
azidocytosine
anhydrous crystalline
hemisulfate
derivative
hemisulfate derivative
Prior art date
Application number
DK03767770T
Other languages
English (en)
Inventor
Terrence Joseph Connolly
Joseph Armstrong Martin
Anthony Prince
Keshab Sarma
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1572711T3 publication Critical patent/DK1572711T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
DK03767770T 2002-12-09 2003-12-08 Vandfrit krystallinsk azidocytosin-hemisulfatderivat DK1572711T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43188502P 2002-12-09 2002-12-09
PCT/EP2003/013899 WO2004052906A1 (en) 2002-12-09 2003-12-08 Anhydrous crystalline azido cytosine hemisulfate derivative

Publications (1)

Publication Number Publication Date
DK1572711T3 true DK1572711T3 (da) 2009-07-13

Family

ID=32507815

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03767770T DK1572711T3 (da) 2002-12-09 2003-12-08 Vandfrit krystallinsk azidocytosin-hemisulfatderivat

Country Status (32)

Country Link
US (1) US6864244B2 (da)
EP (1) EP1572711B1 (da)
JP (1) JP4563818B2 (da)
KR (1) KR100675544B1 (da)
CN (1) CN1314697C (da)
AR (1) AR042312A1 (da)
AT (1) ATE430755T1 (da)
AU (1) AU2003292212B2 (da)
BR (1) BR0317146A (da)
CA (1) CA2506532C (da)
CY (1) CY1109296T1 (da)
DE (1) DE60327554D1 (da)
DK (1) DK1572711T3 (da)
ES (1) ES2324654T3 (da)
GT (1) GT200300276A (da)
HR (1) HRP20050503A2 (da)
IL (1) IL168685A (da)
JO (1) JO2542B1 (da)
MX (1) MXPA05006044A (da)
MY (1) MY130927A (da)
NO (1) NO330454B1 (da)
NZ (1) NZ540297A (da)
PA (1) PA8590701A1 (da)
PE (1) PE20040767A1 (da)
PL (1) PL213734B1 (da)
PT (1) PT1572711E (da)
RU (1) RU2334756C2 (da)
SI (1) SI1572711T1 (da)
TW (1) TWI294882B (da)
UY (1) UY28109A1 (da)
WO (1) WO2004052906A1 (da)
ZA (1) ZA200504472B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1219607B1 (en) * 1999-09-02 2011-04-06 Shionogi & Co., Ltd. Integrase inhibitors containing aromatic heterocycle derivatives
CA2284459C (en) 1999-10-04 2012-12-11 Neokimia Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
US20050182252A1 (en) * 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
DE602005015466D1 (de) * 2004-08-23 2009-08-27 Hoffmann La Roche Antivirale 4'-azidonucleoside
MX2009003452A (es) * 2006-10-10 2009-04-14 Medivir Ab Inhibidores nucleosidicos del vhc.
US8071568B2 (en) 2007-01-05 2011-12-06 Merck Sharp & Dohme Corp. Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
GB0709791D0 (en) * 2007-05-22 2007-06-27 Angeletti P Ist Richerche Bio Antiviral agents
GB0900914D0 (en) 2009-01-20 2009-03-04 Angeletti P Ist Richerche Bio Antiviral agents
EP2619215B1 (en) 2010-09-22 2018-09-05 Alios Biopharma, Inc. Azido nucleosides and nucleotide analogs
US10449210B2 (en) 2014-02-13 2019-10-22 Ligand Pharmaceuticals Inc. Prodrug compounds and their uses
CN103965116B (zh) * 2014-05-06 2016-06-15 中国科学院苏州纳米技术与纳米仿生研究所 半5-氟胞嘧啶盐、其制备方法及应用
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
GEP20217282B (en) 2015-03-06 2021-08-10 Atea Pharmaceuticals Inc β-D-2'-DEOXY-2'α-FLUORO-2'-β-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT
PT3512863T (pt) 2016-09-07 2022-03-09 Atea Pharmaceuticals Inc Nucleótidos de purina 2'-substituídos-n6-substituídos para tratamento de vírus de rna
CN110248951B (zh) 2017-02-01 2022-10-28 阿堤亚制药公司 用于治疗丙型肝炎病毒的核苷酸半硫酸盐
CN111788196A (zh) 2018-01-09 2020-10-16 配体药物公司 缩醛化合物及其治疗用途
WO2019200005A1 (en) 2018-04-10 2019-10-17 Atea Pharmaceuticals, Inc. Treatment of hcv infected patients with cirrhosis
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
BR112023026356A2 (pt) 2021-06-17 2024-03-05 Atea Pharmaceuticals Inc Método para tratar vírus da hepatite c ou uma condição resultante de uma infecção por hepatite c, combinação, uso da combinação, composição farmacêutica, e, kit para o tratamento de vírus da hepatite c
CN115536710B (zh) * 2022-10-18 2024-04-16 南京工业大学 一种高品质胞苷硫酸盐晶体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO171507C (no) * 1988-11-21 1993-03-24 Syntex Inc Analogifremgangsmaate ved fremstilling av terapeutisk aktive nukleotidderivater
US5449664A (en) * 1988-11-21 1995-09-12 Syntex (U.S.A.) Inc. Antiviral agents
AU7623991A (en) * 1990-05-17 1991-11-21 Syntex (U.S.A.) Inc. Antiviral agents
AU738170B2 (en) * 1996-10-16 2001-09-13 Icn Pharmaceuticals, Inc. Monocyclic L-nucleosides, analogs and uses thereof
US20030008841A1 (en) * 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
SI1355916T1 (sl) * 2001-01-22 2007-04-30 Merck & Co Inc Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives

Also Published As

Publication number Publication date
JP4563818B2 (ja) 2010-10-13
PT1572711E (pt) 2009-06-25
DE60327554D1 (de) 2009-06-18
RU2334756C2 (ru) 2008-09-27
EP1572711A1 (en) 2005-09-14
ES2324654T3 (es) 2009-08-12
US6864244B2 (en) 2005-03-08
PE20040767A1 (es) 2004-11-06
PL377472A1 (pl) 2006-02-06
NO20052732D0 (no) 2005-06-07
HRP20050503A2 (en) 2006-12-31
CA2506532A1 (en) 2004-06-24
AR042312A1 (es) 2005-06-15
JP2006510649A (ja) 2006-03-30
SI1572711T1 (sl) 2009-08-31
CY1109296T1 (el) 2014-07-02
US20040162265A1 (en) 2004-08-19
PL213734B1 (pl) 2013-04-30
NZ540297A (en) 2007-05-31
TWI294882B (en) 2008-03-21
BR0317146A (pt) 2005-10-25
PA8590701A1 (es) 2004-11-26
WO2004052906A1 (en) 2004-06-24
CA2506532C (en) 2011-09-20
HK1085483A1 (en) 2006-08-25
TW200502243A (en) 2005-01-16
RU2005121927A (ru) 2006-01-27
IL168685A (en) 2010-11-30
AU2003292212A1 (en) 2004-06-30
KR20050084217A (ko) 2005-08-26
MXPA05006044A (es) 2005-08-18
CN1723215A (zh) 2006-01-18
JO2542B1 (en) 2010-09-05
KR100675544B1 (ko) 2007-01-30
EP1572711B1 (en) 2009-05-06
AU2003292212B2 (en) 2009-10-01
MY130927A (en) 2007-07-31
NO330454B1 (no) 2011-04-18
CN1314697C (zh) 2007-05-09
UY28109A1 (es) 2004-06-30
ZA200504472B (en) 2006-02-22
ATE430755T1 (de) 2009-05-15
NO20052732L (no) 2005-09-06
GT200300276A (es) 2004-09-02

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