ATE430755T1 - Wasserfreies kristallines azidocytosin-hemisulfat-derivat - Google Patents

Wasserfreies kristallines azidocytosin-hemisulfat-derivat

Info

Publication number
ATE430755T1
ATE430755T1 AT03767770T AT03767770T ATE430755T1 AT E430755 T1 ATE430755 T1 AT E430755T1 AT 03767770 T AT03767770 T AT 03767770T AT 03767770 T AT03767770 T AT 03767770T AT E430755 T1 ATE430755 T1 AT E430755T1
Authority
AT
Austria
Prior art keywords
azidocytosine
hemisulphate
derivative
anhydrous crystalline
anhydrous
Prior art date
Application number
AT03767770T
Other languages
English (en)
Inventor
Terrence Joseph Connolly
Joseph Armstrong Martin
Anthony Prince
Keshab Sarma
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE430755T1 publication Critical patent/ATE430755T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
AT03767770T 2002-12-09 2003-12-08 Wasserfreies kristallines azidocytosin-hemisulfat-derivat ATE430755T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43188502P 2002-12-09 2002-12-09
PCT/EP2003/013899 WO2004052906A1 (en) 2002-12-09 2003-12-08 Anhydrous crystalline azido cytosine hemisulfate derivative

Publications (1)

Publication Number Publication Date
ATE430755T1 true ATE430755T1 (de) 2009-05-15

Family

ID=32507815

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03767770T ATE430755T1 (de) 2002-12-09 2003-12-08 Wasserfreies kristallines azidocytosin-hemisulfat-derivat

Country Status (32)

Country Link
US (1) US6864244B2 (de)
EP (1) EP1572711B1 (de)
JP (1) JP4563818B2 (de)
KR (1) KR100675544B1 (de)
CN (1) CN1314697C (de)
AR (1) AR042312A1 (de)
AT (1) ATE430755T1 (de)
AU (1) AU2003292212B2 (de)
BR (1) BR0317146A (de)
CA (1) CA2506532C (de)
CY (1) CY1109296T1 (de)
DE (1) DE60327554D1 (de)
DK (1) DK1572711T3 (de)
ES (1) ES2324654T3 (de)
GT (1) GT200300276A (de)
HR (1) HRP20050503A2 (de)
IL (1) IL168685A (de)
JO (1) JO2542B1 (de)
MX (1) MXPA05006044A (de)
MY (1) MY130927A (de)
NO (1) NO330454B1 (de)
NZ (1) NZ540297A (de)
PA (1) PA8590701A1 (de)
PE (1) PE20040767A1 (de)
PL (1) PL213734B1 (de)
PT (1) PT1572711E (de)
RU (1) RU2334756C2 (de)
SI (1) SI1572711T1 (de)
TW (1) TWI294882B (de)
UY (1) UY28109A1 (de)
WO (1) WO2004052906A1 (de)
ZA (1) ZA200504472B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6731100A (en) * 1999-09-02 2001-04-10 Shionogi & Co., Ltd. Integrase inhibitors containing aromatic heterocycle derivatives
CA2284459C (en) 1999-10-04 2012-12-11 Neokimia Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
US20050182252A1 (en) * 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
ES2327252T3 (es) * 2004-08-23 2009-10-27 F. Hoffmann-La Roche Ag 4'-azido nucleosidos antivirales.
HRP20110193T1 (hr) * 2006-10-10 2011-05-31 Medivir Ab Inhibitor hcv nukleozida
AU2007342367B2 (en) 2007-01-05 2012-12-06 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
GB0709791D0 (en) * 2007-05-22 2007-06-27 Angeletti P Ist Richerche Bio Antiviral agents
GB0900914D0 (en) 2009-01-20 2009-03-04 Angeletti P Ist Richerche Bio Antiviral agents
AU2011305652B2 (en) 2010-09-22 2016-10-20 Janssen Biopharma, Inc. Azido nucleosides and nucleotide analogs
EP3623364A1 (de) 2014-02-13 2020-03-18 Ligand Pharmaceuticals, Inc. Organische verbindungen und deren verwendungen
CN103965116B (zh) * 2014-05-06 2016-06-15 中国科学院苏州纳米技术与纳米仿生研究所 半5-氟胞嘧啶盐、其制备方法及应用
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
FI3265102T3 (fi) 2015-03-06 2025-10-31 Atea Pharmaceuticals Inc Beta-d-2'-deoksi-2'-alfa-fluori-2'-beta-c-substituoituja-2-modifioituja-n6-substituoituja puriininukleotideja hcv-hoitoa varten
PT3512863T (pt) 2016-09-07 2022-03-09 Atea Pharmaceuticals Inc Nucleótidos de purina 2'-substituídos-n6-substituídos para tratamento de vírus de rna
CN115477679A (zh) 2017-02-01 2022-12-16 阿堤亚制药公司 用于治疗丙型肝炎病毒的核苷酸半硫酸盐
WO2019139919A1 (en) 2018-01-09 2019-07-18 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof
CN112351799A (zh) 2018-04-10 2021-02-09 阿堤亚制药公司 具有硬化的hcv感染患者的治疗
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
WO2022164941A1 (en) 2021-01-26 2022-08-04 Atea Pharmaceuticals, Inc. Advantageous morphic form of at-527 hemi-sulfate salt
AU2022291927A1 (en) 2021-06-17 2024-01-04 Atea Pharmaceuticals, Inc. Advantageous anti-hcv combination therapy
CN115536710B (zh) * 2022-10-18 2024-04-16 南京工业大学 一种高品质胞苷硫酸盐晶体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5449664A (en) * 1988-11-21 1995-09-12 Syntex (U.S.A.) Inc. Antiviral agents
PH27609A (en) * 1988-11-21 1993-08-31 Syntex Inc Antiviral agents
AU7623991A (en) * 1990-05-17 1991-11-21 Syntex (U.S.A.) Inc. Antiviral agents
SK284054B6 (sk) * 1996-10-16 2004-08-03 Icn Pharmaceuticals, Inc. Substituované triazolové nukleozidy, farmaceutický prostriedok s ich obsahom a ich použitie
US20030008841A1 (en) * 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
MXPA03006514A (es) * 2001-01-22 2004-12-02 Merck & Co Inc Derivados de nucleosidos como inhibidores de polimerasa de acido ribonucleico viral dependiente de acido ribonucleico.
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives

Also Published As

Publication number Publication date
CA2506532A1 (en) 2004-06-24
PL377472A1 (pl) 2006-02-06
JP4563818B2 (ja) 2010-10-13
NO20052732L (no) 2005-09-06
EP1572711B1 (de) 2009-05-06
AR042312A1 (es) 2005-06-15
MXPA05006044A (es) 2005-08-18
IL168685A (en) 2010-11-30
CN1723215A (zh) 2006-01-18
RU2005121927A (ru) 2006-01-27
DE60327554D1 (de) 2009-06-18
TW200502243A (en) 2005-01-16
CY1109296T1 (el) 2014-07-02
PL213734B1 (pl) 2013-04-30
AU2003292212B2 (en) 2009-10-01
JO2542B1 (en) 2010-09-05
RU2334756C2 (ru) 2008-09-27
PT1572711E (pt) 2009-06-25
EP1572711A1 (de) 2005-09-14
KR100675544B1 (ko) 2007-01-30
CN1314697C (zh) 2007-05-09
ES2324654T3 (es) 2009-08-12
TWI294882B (en) 2008-03-21
UY28109A1 (es) 2004-06-30
HK1085483A1 (en) 2006-08-25
KR20050084217A (ko) 2005-08-26
NO330454B1 (no) 2011-04-18
PA8590701A1 (es) 2004-11-26
DK1572711T3 (da) 2009-07-13
NZ540297A (en) 2007-05-31
HRP20050503A2 (en) 2006-12-31
US20040162265A1 (en) 2004-08-19
PE20040767A1 (es) 2004-11-06
US6864244B2 (en) 2005-03-08
BR0317146A (pt) 2005-10-25
AU2003292212A1 (en) 2004-06-30
ZA200504472B (en) 2006-02-22
MY130927A (en) 2007-07-31
WO2004052906A1 (en) 2004-06-24
NO20052732D0 (no) 2005-06-07
SI1572711T1 (sl) 2009-08-31
GT200300276A (es) 2004-09-02
CA2506532C (en) 2011-09-20
JP2006510649A (ja) 2006-03-30

Similar Documents

Publication Publication Date Title
DK1490355T3 (da) Indolylmaleimidderivater
DE60336314D1 (de) Substituierte indole
DK1515969T3 (da) Spiroindolinpiperidinderivater
ATE460418T1 (de) Heterocyclocarboxamidderivate
DE60330372D1 (de) Indol-3-schwefelderivate
ATE467631T1 (de) Chinuclidinamidderivate
ATE438644T1 (de) Chinazolinderivate
IS7720A (is) Píperidín-N-oxíð-afleiður
DK2248807T3 (da) N-Phenyl-2-pyrimidinaminderivater
DK1572711T3 (da) Vandfrit krystallinsk azidocytosin-hemisulfatderivat
ATE308543T1 (de) Piperidinderivate
DE60307512D1 (de) 3h-chinazoline -4-on derivaten
ATE496887T1 (de) Substituierte 5-aminomethyl-1h-pyrrol-2-carbons ureamide
ATE423771T1 (de) Tetrahydrochinolinderivate
ATE457299T1 (de) 4-hydroxymethyl-1-aryl-cyclohexylamin-derivativ
IS7833A (is) Efnasambönd með sameinaða heteróhringi
ATE415523T1 (de) Bohrkopf
DE50301969D1 (de) Kommissioniergerät
DE50306277D1 (de) 4-alkyl-/4-alkenyl-/4-alkinylmethyl/-1-arylcyclohexylamin-derivate
NO20055097D0 (no) Krystallinske N-formyl-hydroksylaminforbindelser
NO20044302L (no) Krystallinsk parecoxibnatrium
NO20044364L (no) Hydroksykarbamimidoyl-2-hydroksy-benzensulfonamidderivat-krystaller
ATE350379T1 (de) Substituierte benzdioxepine
IS7906A (is) Afleiður própargýl-tríflúorómetoxý-amínó-benzóþíazóls
FI5900U1 (fi) Poranterä

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1572711

Country of ref document: EP