PL378438A1 - Przemysłowy sposób wytwarzania 2-podstawionych kwasów 1-(hydroksyetylideno)-1,1-bisfosfonowych o wysokiej czystości i ich soli - Google Patents

Przemysłowy sposób wytwarzania 2-podstawionych kwasów 1-(hydroksyetylideno)-1,1-bisfosfonowych o wysokiej czystości i ich soli

Info

Publication number: PL378438A1
Authority: PL; Poland
Prior art keywords: salts; ethylidene; hydroxy; synthesis; substituted
Prior art date: 2003-01-28

Application number

PL378438A

Other languages

English (en)

Other versions

PL214441B1 (pl

Inventor

Jozsef Neu

Janos Fischer

Tamas Fodor

Jozsef Törley

Tibor Gizur

Sandor Levai

Adam Demeter

Eva Perenyi

Original Assignee

Richter Gedeon Vegyeszeti Gyar Rt.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-01-28

Filing date

2004-01-27

Publication date

2006-04-03

2004-01-27 Application filed by Richter Gedeon Vegyeszeti Gyar Rt. filed Critical Richter Gedeon Vegyeszeti Gyar Rt.

2006-04-03 Publication of PL378438A1 publication Critical patent/PL378438A1/pl

2013-08-30 Publication of PL214441B1 publication Critical patent/PL214441B1/pl

Links

150000003839 salts Chemical class 0.000 title abstract 4
239000002253 acid Substances 0.000 title abstract 3
230000015572 biosynthetic process Effects 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
150000007513 acids Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 2
150000004677 hydrates Chemical class 0.000 abstract 2
239000003153 chemical reaction reagent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
YWEUIGNSBFLMFL-UHFFFAOYSA-N diphosphonate Chemical compound O=P(=O)OP(=O)=O YWEUIGNSBFLMFL-UHFFFAOYSA-N 0.000 abstract 1
229940098779 methanesulfonic acid Drugs 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 abstract 1
ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

PL378438A 2003-01-28 2004-01-27 Sposób wytwarzania 2-podstawionych kwasów 1-(hydroksyetylideno)-1,1-bisfosfonowych i ich soli PL214441B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU0300227A HUP0300227A2 (hu)	2003-01-28	2003-01-28	Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására

Publications (2)

Publication Number	Publication Date
PL378438A1 true PL378438A1 (pl)	2006-04-03
PL214441B1 PL214441B1 (pl)	2013-08-30

Family

ID=89981108

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL378438A PL214441B1 (pl)	2003-01-28	2004-01-27	Sposób wytwarzania 2-podstawionych kwasów 1-(hydroksyetylideno)-1,1-bisfosfonowych i ich soli

Country Status (9)

Country	Link
US (1)	US7612229B2 (pl)
EP (1)	EP1587814B1 (pl)
AT (1)	ATE420885T1 (pl)
DE (1)	DE602004019047D1 (pl)
EA (1)	EA007947B1 (pl)
HU (1)	HUP0300227A2 (pl)
PL (1)	PL214441B1 (pl)
UA (1)	UA80023C2 (pl)
WO (1)	WO2004067541A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100681282B1 (ko) *	2002-05-17	2007-02-12	테바 파마슈티컬 인더스트리즈 리미티드	특정 희석제를 사용하는 비스포스폰산 및 그 염의 제조방법
HUP0300227A2 (hu) *	2003-01-28	2004-09-28	Richter Gedeon Vegyészeti Gyár Rt.	Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
EP1883644A2 (en) *	2005-05-06	2008-02-06	Medichem, S.A.	Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof
JP5354858B2 (ja) *	2006-05-09	2013-11-27	株式会社Ａｄｅｋａ	スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
WO2007132478A2 (en)	2006-05-11	2007-11-22	Ind-Swift Laboratories Limited	Process for the preparation of pure risedronic acid or salts
US20100317859A1 (en) *	2007-05-16	2010-12-16	Actavis Group Ptc Ehf	Process for the Preparation of Risedronate Sodium
WO2009050731A2 (en) *	2007-06-20	2009-04-23	Alkem Laboratories Ltd	Novel process for preparing risedronic acid
PL2483283T3 (pl) *	2009-10-02	2015-06-30	Monsanto Technology Llc	Sposób wytwarzania kwasów aminohydroksydifosfonowych
EP2665734B1 (en) *	2011-01-21	2016-06-29	Straitmark Holding AG	METHOD FOR THE MANUFACTURE OF COMPOUNDS CONTAINING AN alpha-OXY PHOSPHORUS GROUP
CN121203646B (zh) *	2025-11-28	2026-02-24	四川雷驰力奥石油科技有限公司	一种防垢交联聚合物压裂液体及其制备方法

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DE2702631A1 (de)	1977-01-22	1978-07-27	Henkel Kgaa	Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren
DE3016289A1 (de) *	1980-04-28	1981-10-29	Henkel KGaA, 4000 Düsseldorf	Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
DE3428524A1 (de) *	1984-08-02	1986-02-13	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4990503A (en) *	1988-08-12	1991-02-05	Yamanouchi Pharmaceutical Co., Ltd.	Heterocyclic bisphosphonic acid derivatives
US4922007A (en) *	1989-06-09	1990-05-01	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) *	1990-06-20	1991-05-28	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5159108A (en) *	1990-09-18	1992-10-27	Merck & Co., Inc.	Process for preparing an antihypercalcemic agent
US5039819A (en) *	1990-09-18	1991-08-13	Merck & Co., Inc.	Diphosphonate intermediate for preparing an antihypercalcemic agent
IT1246992B (it)	1991-01-08	1994-12-12	Gentili Ist Spa	Procedimento per la preparazione di acidi difosfonici e loro sali
IT1244698B (it) *	1991-02-01	1994-08-08	Gentili Ist Spa	Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale
CA2197267C (en) *	1997-02-11	2000-02-08	Yong Tao	Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5908859A (en) *	1997-08-11	1999-06-01	Eli Lilly And Company	Benzothiophenes for inhibiting hyperlipidemia
EP1169326B1 (en) *	1999-02-17	2004-07-14	Teva Pharmaceutical Industries Ltd.	Process for preparing alendronic acid
ES2153794B1 (es)	1999-08-06	2001-10-16	Medichem Sa	Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
US6410520B2 (en) *	2000-02-01	2002-06-25	The Procter & Gamble Company	Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
TR200101250A2 (tr) *	2001-05-10	2003-04-21	E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�.	4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
DE602004015407D1 (de) *	2003-01-17	2008-09-11	Teva Pharma	Verfahren zur reduzierung des eisengehalts bei risedronat natrium
HUP0300227A2 (hu) *	2003-01-28	2004-09-28	Richter Gedeon Vegyészeti Gyár Rt.	Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
JP4642762B2 (ja) *	2003-08-21	2011-03-02	サン・ファーマシューティカル・インダストリーズ・リミテッド	ビスホスホン酸化合物の製造方法

2003
- 2003-01-28 HU HU0300227A patent/HUP0300227A2/hu unknown
2004
- 2004-01-27 EP EP04705466A patent/EP1587814B1/en not_active Expired - Lifetime
- 2004-01-27 DE DE602004019047T patent/DE602004019047D1/de not_active Expired - Lifetime
- 2004-01-27 WO PCT/HU2004/000009 patent/WO2004067541A1/en not_active Ceased
- 2004-01-27 US US10/541,866 patent/US7612229B2/en not_active Expired - Lifetime
- 2004-01-27 UA UAA200508269A patent/UA80023C2/uk unknown
- 2004-01-27 EA EA200501188A patent/EA007947B1/ru not_active IP Right Cessation
- 2004-01-27 PL PL378438A patent/PL214441B1/pl unknown
- 2004-01-27 AT AT04705466T patent/ATE420885T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL214441B1 (pl)	2013-08-30
EP1587814B1 (en)	2009-01-14
EA200501188A1 (ru)	2005-12-29
ATE420885T1 (de)	2009-01-15
HU0300227D0 (en)	2003-03-28
UA80023C2 (en)	2007-08-10
US20060122395A1 (en)	2006-06-08
DE602004019047D1 (de)	2009-03-05
US7612229B2 (en)	2009-11-03
EA007947B1 (ru)	2007-02-27
EP1587814A1 (en)	2005-10-26
HUP0300227A2 (hu)	2004-09-28
WO2004067541A1 (en)	2004-08-12

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Legal Events

Date	Code	Title	Description
2014-01-31	RECP	Rectifications of patent specification