PL378438A1 - Przemysłowy sposób wytwarzania 2-podstawionych kwasów 1-(hydroksyetylideno)-1,1-bisfosfonowych o wysokiej czystości i ich soli - Google Patents

Przemysłowy sposób wytwarzania 2-podstawionych kwasów 1-(hydroksyetylideno)-1,1-bisfosfonowych o wysokiej czystości i ich soli

Info

Publication number: PL378438A1
Authority: PL; Poland
Prior art keywords: salts; ethylidene; hydroxy; synthesis; substituted
Prior art date: 2003-01-28

Application number

PL378438A

Other languages

English (en)

Other versions

PL214441B1 (pl

Inventor

Jozsef Neu

Janos Fischer

Tamas Fodor

Jozsef Törley

Tibor Gizur

Sandor Levai

Adam Demeter

Eva Perenyi

Original Assignee

Richter Gedeon Vegyeszeti Gyar Rt.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-01-28

Filing date

2004-01-27

Publication date

2006-04-03

2004-01-27 Application filed by Richter Gedeon Vegyeszeti Gyar Rt. filed Critical Richter Gedeon Vegyeszeti Gyar Rt.

2006-04-03 Publication of PL378438A1 publication Critical patent/PL378438A1/pl

2013-08-30 Publication of PL214441B1 publication Critical patent/PL214441B1/pl

Links

150000003839 salts Chemical class 0.000 title abstract 4
239000002253 acid Substances 0.000 title abstract 3
230000015572 biosynthetic process Effects 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
150000007513 acids Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 2
150000004677 hydrates Chemical class 0.000 abstract 2
239000003153 chemical reaction reagent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
YWEUIGNSBFLMFL-UHFFFAOYSA-N diphosphonate Chemical compound O=P(=O)OP(=O)=O YWEUIGNSBFLMFL-UHFFFAOYSA-N 0.000 abstract 1
229940098779 methanesulfonic acid Drugs 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 abstract 1
ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

PL378438A 2003-01-28 2004-01-27 Sposób wytwarzania 2-podstawionych kwasów 1-(hydroksyetylideno)-1,1-bisfosfonowych i ich soli PL214441B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU0300227A HUP0300227A2 (hu)	2003-01-28	2003-01-28	Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására

Publications (2)

Publication Number	Publication Date
PL378438A1 true PL378438A1 (pl)	2006-04-03
PL214441B1 PL214441B1 (pl)	2013-08-30

Family

ID=89981108

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL378438A PL214441B1 (pl)	2003-01-28	2004-01-27	Sposób wytwarzania 2-podstawionych kwasów 1-(hydroksyetylideno)-1,1-bisfosfonowych i ich soli

Country Status (9)

Country	Link
US (1)	US7612229B2 (pl)
EP (1)	EP1587814B1 (pl)
AT (1)	ATE420885T1 (pl)
DE (1)	DE602004019047D1 (pl)
EA (1)	EA007947B1 (pl)
HU (1)	HUP0300227A2 (pl)
PL (1)	PL214441B1 (pl)
UA (1)	UA80023C2 (pl)
WO (1)	WO2004067541A1 (pl)

Families Citing this family (10)

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EP1476451B1 (en) *	2002-05-17	2010-03-17	Teva Pharmaceutical Industries Ltd.	Use of certain diluents for making bisphosphonic acids
HUP0300227A2 (hu) *	2003-01-28	2004-09-28	Richter Gedeon Vegyészeti Gyár Rt.	Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
US20080194525A1 (en) *	2005-05-06	2008-08-14	Jordi Puig Serrano	Process of Making Geminal Bisphosphonic Acids and Pharmaceutically Acceptable Salts and/or Hydrates Thereof
JP5354858B2 (ja) *	2006-05-09	2013-11-27	株式会社Ａｄｅｋａ	スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
JP2009536639A (ja)	2006-05-11	2009-10-15	アイエヌディー−スイフトラボラトリーズリミテッド	純リセドロン酸または塩を調製するための方法
WO2008152518A2 (en) *	2007-05-16	2008-12-18	Actavis Group Ptc Ehf	Process for the preparation of risedronic acid or risedronate sodium
WO2009050731A2 (en) *	2007-06-20	2009-04-23	Alkem Laboratories Ltd	Novel process for preparing risedronic acid
CN102639545B (zh) *	2009-10-02	2016-08-03	施里特马克控股公司	制备氨基羟基二膦酸的方法
WO2012098255A1 (en) *	2011-01-21	2012-07-26	Straitmark Holding Ag	METHOD FOR THE MANUFACTURE OF COMPOUNDS CONTAINING AN α-OXY PHOSPHORUS GROUP
CN121203646B (zh) *	2025-11-28	2026-02-24	四川雷驰力奥石油科技有限公司	一种防垢交联聚合物压裂液体及其制备方法

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DE2702631A1 (de)	1977-01-22	1978-07-27	Henkel Kgaa	Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren
DE3016289A1 (de) *	1980-04-28	1981-10-29	Henkel KGaA, 4000 Düsseldorf	Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
DE3428524A1 (de) *	1984-08-02	1986-02-13	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4990503A (en) *	1988-08-12	1991-02-05	Yamanouchi Pharmaceutical Co., Ltd.	Heterocyclic bisphosphonic acid derivatives
US4922007A (en) *	1989-06-09	1990-05-01	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
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CA2197267C (en)	1997-02-11	2000-02-08	Yong Tao	Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5908859A (en) *	1997-08-11	1999-06-01	Eli Lilly And Company	Benzothiophenes for inhibiting hyperlipidemia
HK1041004B (en) *	1999-02-17	2005-01-21	Teva Pharmaceutical Industries Ltd.	Process for preparing alendronic acid
ES2153794B1 (es)	1999-08-06	2001-10-16	Medichem Sa	Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
PE20011061A1 (es) *	2000-02-01	2001-11-20	Procter & Gamble	Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato
TR200101250A2 (tr) *	2001-05-10	2003-04-21	E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�.	4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
ES2311142T3 (es) *	2003-01-17	2009-02-01	Teva Pharmaceutical Industries Limited	Procedimiento para reducir el contenido de hierro del risedronato sodico.
HUP0300227A2 (hu) *	2003-01-28	2004-09-28	Richter Gedeon Vegyészeti Gyár Rt.	Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
JP4642762B2 (ja) *	2003-08-21	2011-03-02	サン・ファーマシューティカル・インダストリーズ・リミテッド	ビスホスホン酸化合物の製造方法

2003
- 2003-01-28 HU HU0300227A patent/HUP0300227A2/hu unknown
2004
- 2004-01-27 US US10/541,866 patent/US7612229B2/en not_active Expired - Lifetime
- 2004-01-27 EP EP04705466A patent/EP1587814B1/en not_active Expired - Lifetime
- 2004-01-27 UA UAA200508269A patent/UA80023C2/uk unknown
- 2004-01-27 EA EA200501188A patent/EA007947B1/ru not_active IP Right Cessation
- 2004-01-27 DE DE602004019047T patent/DE602004019047D1/de not_active Expired - Lifetime
- 2004-01-27 WO PCT/HU2004/000009 patent/WO2004067541A1/en not_active Ceased
- 2004-01-27 AT AT04705466T patent/ATE420885T1/de not_active IP Right Cessation
- 2004-01-27 PL PL378438A patent/PL214441B1/pl unknown

Also Published As

Publication number	Publication date
PL214441B1 (pl)	2013-08-30
ATE420885T1 (de)	2009-01-15
EP1587814A1 (en)	2005-10-26
HUP0300227A2 (hu)	2004-09-28
HU0300227D0 (en)	2003-03-28
EP1587814B1 (en)	2009-01-14
DE602004019047D1 (de)	2009-03-05
US7612229B2 (en)	2009-11-03
UA80023C2 (en)	2007-08-10
EA007947B1 (ru)	2007-02-27
WO2004067541A1 (en)	2004-08-12
US20060122395A1 (en)	2006-06-08
EA200501188A1 (ru)	2005-12-29

Legal Events

Date	Code	Title	Description
2014-01-31	RECP	Rectifications of patent specification

Publication	Publication Date	Title
NZ536734A (en)	2006-03-31	Spiroindolinepiperidine derivatives
PL378438A1 (pl)	2006-04-03	Przemysłowy sposób wytwarzania 2-podstawionych kwasów 1-(hydroksyetylideno)-1,1-bisfosfonowych o wysokiej czystości i ich soli
PL1656386T3 (pl)	2010-05-31	Proces wytwarzania związków kwasu difosfonowego
AU2507088A (en)	1989-05-25	Amino acid derivatives of phosphorus acids
WO2002100860A3 (fr)	2003-11-20	Composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
EP1338595A3 (en)	2003-10-08	Xanthine derivatives as DPP-IV inhibitors
PT1089724E (pt)	2009-07-20	Derivados de ácido oleanólico substituídos com ciano como inibidores da produção de no
CY1107403T1 (el)	2012-12-19	Μια μεθοδος δια την παρασκευη υπερινδοπριλης,των αναλογων ενωσεων αυτης και των αλατων αυτων με χρησιμοποιηση ενδιαμεσων ενωσεων 2,5-διοξο-οξαζολιδινης
ATE427339T1 (de)	2009-04-15	Flammschutzmittel-stabilisator-kombination fur thermoplastische polymere
TW200630376A (en)	2006-09-01	Process for preparing acylphosphanes and derivatives thereof
AU2001232039A1 (en)	2001-08-20	Aromatic polyetherketones
ATE508134T1 (de)	2011-05-15	Amorphe form das natriumsalzes der ibandronsäure
SG158864A1 (en)	2010-02-26	Processes for preparing 4-(phenoxy-5-methyl-pyrimidin-4-yloxy)piperidine-1- carboxylic acid derivatives and related compounds
MY129831A (en)	2007-05-31	Process for preparing aripiprazole
EP1217003B8 (de)	2006-05-03	Verfahren zur Herstellung von Ethanbis(methylphosphinsäure)
HU9800865D0 (en)	1998-05-28	Condensed piperidine compounds
IL160405A0 (en)	2009-02-11	Flame retardant for polymeric materials
HRP20030435B1 (en)	2011-10-31	Process for the preparation of donepezil
WO2002053535A3 (en)	2003-01-23	Process for making amlodipine, derivatives thereof, and precursors therefor
AR029452A1 (es)	2003-07-02	Compuestos de 4-amino-3-alcoxiiminapirrolidina, utilizables en la preparacion de derivados de acidos quinolincarboxilicos y de sales e hidratos farmaceuticamente aceptables de los mismos y procedimiento de preparacion de dicho compuesto, respectivamente de dichos derivados
DE60013861D1 (de)	2004-10-21	Herstellungsverfahren für venlafaxin
AU2002304846A1 (en)	2002-10-08	Method of producing 1-hydroxy-1,1-diphosphonic acid compounds
SE0101323D0 (sv)	2001-04-12	New process
BR0113037A (pt)	2004-01-20	Processo para preparação de 2-(4-piridil) amino-6-dialquilox fenil-pirido[2,3-d] pirimidin-7-onas
MXPA04000952A (es)	2004-04-20	Sales de derivados de acido 1,2,3-4-tetrahidro-isoquinolin-2-carboxilico.