ATE420885T1 - Grosstechnisches verfahren zur synthese von hochreinen 2-substituierten 1-(hydroxyethyliden)- 1,1-bisphosphonsäuren und deren salzen - Google Patents

Grosstechnisches verfahren zur synthese von hochreinen 2-substituierten 1-(hydroxyethyliden)- 1,1-bisphosphonsäuren und deren salzen

Info

Publication number
ATE420885T1
ATE420885T1 AT04705466T AT04705466T ATE420885T1 AT E420885 T1 ATE420885 T1 AT E420885T1 AT 04705466 T AT04705466 T AT 04705466T AT 04705466 T AT04705466 T AT 04705466T AT E420885 T1 ATE420885 T1 AT E420885T1
Authority
AT
Austria
Prior art keywords
salts
synthesis
substituted
hydroxyethylidene
technical process
Prior art date
Application number
AT04705466T
Other languages
English (en)
Inventor
Jozsef Neu
Janos Fischer
Tamas Fodor
Jozsef Toerley
Tibor Gizur
Sandor Levai
Adam Demeter
Eva Perenyi
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Application granted granted Critical
Publication of ATE420885T1 publication Critical patent/ATE420885T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT04705466T 2003-01-28 2004-01-27 Grosstechnisches verfahren zur synthese von hochreinen 2-substituierten 1-(hydroxyethyliden)- 1,1-bisphosphonsäuren und deren salzen ATE420885T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0300227A HUP0300227A2 (hu) 2003-01-28 2003-01-28 Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására

Publications (1)

Publication Number Publication Date
ATE420885T1 true ATE420885T1 (de) 2009-01-15

Family

ID=89981108

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04705466T ATE420885T1 (de) 2003-01-28 2004-01-27 Grosstechnisches verfahren zur synthese von hochreinen 2-substituierten 1-(hydroxyethyliden)- 1,1-bisphosphonsäuren und deren salzen

Country Status (9)

Country Link
US (1) US7612229B2 (de)
EP (1) EP1587814B1 (de)
AT (1) ATE420885T1 (de)
DE (1) DE602004019047D1 (de)
EA (1) EA007947B1 (de)
HU (1) HUP0300227A2 (de)
PL (1) PL214441B1 (de)
UA (1) UA80023C2 (de)
WO (1) WO2004067541A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE461205T1 (de) * 2002-05-17 2010-04-15 Teva Pharma Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
EP1883644A2 (de) * 2005-05-06 2008-02-06 Medichem, S.A. Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof
JP5354858B2 (ja) * 2006-05-09 2013-11-27 株式会社Ａｄｅｋａ スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
EP2016084A2 (de) 2006-05-11 2009-01-21 Ind-Swift Laboratories Limited Verfahren zur herstellung von reiner risedronsäure oder -salzen
WO2008152518A2 (en) * 2007-05-16 2008-12-18 Actavis Group Ptc Ehf Process for the preparation of risedronic acid or risedronate sodium
WO2009050731A2 (en) * 2007-06-20 2009-04-23 Alkem Laboratories Ltd Novel process for preparing risedronic acid
CA2775004A1 (en) * 2009-10-02 2011-04-07 Straitmark Holding Ag Method for the manufacture of aminohydroxy diphosphonic acids
EP2665734B1 (de) * 2011-01-21 2016-06-29 Straitmark Holding AG Verfahren zur herstellung von verbindungen mit einer alpha-oxy-phosphorgruppe
CN121203646B (zh) * 2025-11-28 2026-02-24 四川雷驰力奥石油科技有限公司 一种防垢交联聚合物压裂液体及其制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2702631A1 (de) 1977-01-22 1978-07-27 Henkel Kgaa Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren
DE3016289A1 (de) 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
DE3428524A1 (de) 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4990503A (en) 1988-08-12 1991-02-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic bisphosphonic acid derivatives
US4922007A (en) 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5159108A (en) * 1990-09-18 1992-10-27 Merck & Co., Inc. Process for preparing an antihypercalcemic agent
US5039819A (en) * 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
IT1246992B (it) 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
IT1244698B (it) * 1991-02-01 1994-08-08 Gentili Ist Spa Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale
CA2197267C (en) 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5908859A (en) 1997-08-11 1999-06-01 Eli Lilly And Company Benzothiophenes for inhibiting hyperlipidemia
YU59401A (sh) * 1999-02-17 2004-05-12 Teva Pharmaceutical Industries Ltd. Postupak za proizvodnju alendronske kiseline
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
PE20011061A1 (es) * 2000-02-01 2001-11-20 Procter & Gamble Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
JP3869456B2 (ja) * 2003-01-17 2007-01-17 テバ ファーマシューティカル インダストリーズ リミティド 鉄含有量が非常に低いリセドロン酸ナトリウム
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
ES2337063T3 (es) * 2003-08-21 2010-04-20 Sun Pharmaceuticals Industries Ltd. Proceso para la preparacion de acido bisfosfonico.

Also Published As

Publication number Publication date
PL378438A1 (pl) 2006-04-03
HU0300227D0 (en) 2003-03-28
HUP0300227A2 (hu) 2004-09-28
UA80023C2 (en) 2007-08-10
DE602004019047D1 (de) 2009-03-05
US7612229B2 (en) 2009-11-03
EA200501188A1 (ru) 2005-12-29
EP1587814A1 (de) 2005-10-26
US20060122395A1 (en) 2006-06-08
EA007947B1 (ru) 2007-02-27
EP1587814B1 (de) 2009-01-14
WO2004067541A1 (en) 2004-08-12
PL214441B1 (pl) 2013-08-30

Similar Documents

Publication Publication Date Title
MXPA03011039A (es) Nuevos compuestos heterociclicos, su preparacion y uso como medicamentos, particularmente como agentes anti-bacterianos.
EA200300211A1 (ru) Азабициклические соединения, способ их получения и их применение в качестве лекарственных средств, в частности в качестве антибактериальных средств
NZ536734A (en) Spiroindolinepiperidine derivatives
DE602004019047D1 (de) Grosstechnisches verfahren zur synthese von hochreinen 2-substituierten 1-(hydroxyethyliden)-1,1-bisphosphonsäuren und deren salzen
ATE246694T1 (de) Verfahren zur herstellung von dialkylphosphinsäuren und deren salzen
CY1107403T1 (el) Μια μεθοδος δια την παρασκευη υπερινδοπριλης,των αναλογων ενωσεων αυτης και των αλατων αυτων με χρησιμοποιηση ενδιαμεσων ενωσεων 2,5-διοξο-οξαζολιδινης
ATE544744T1 (de) Verfahren zur herstellung von benzoesaure derivaten
EA200100533A1 (ru) Производные эритромицина, способ их получения и их применение в качестве лекарственных средств
DE69808093D1 (de) Verfahren zur herstellung von 2-substituierten 1-(tetrazol-5-yl)benzenverbindungen durch ortho-metallierung
SG158864A1 (en) Processes for preparing 4-(phenoxy-5-methyl-pyrimidin-4-yloxy)piperidine-1- carboxylic acid derivatives and related compounds
DE50108846D1 (de) Verfahren zur Herstellung von Ethanbis(methylphosphinsäure)
ATE532516T1 (de) Verfahren zur synthese von glyt-1-hemmern
ATE343385T1 (de) Verfahren zur herstellung von donepezil
UA86031C2 (ru) Применение скопинового эфира как исходного материала для получения соединений, которые проявляют терапевтическое действие
ATE348810T1 (de) Verfahren zur herstellung von 2-aminomethyl- halogen-pyridinen
ATE267799T1 (de) Ein verfahren zur herstellung von (2s,2'r,3'r)-2- (2,3-dicarboxycyclopropyl)-glycin
EA200200807A1 (ru) Аминокислотные соединения и их применение в качестве ингибиторов nep, ace и ece
DE60002347D1 (de) Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure und ihres trihydratisierten mononatriumsalzes
EA200300458A1 (ru) Новые соединения аминотриазолона, способ их получения и фармацевтические композиции, содержащие их
EP1227081A4 (de) Verfahren zur herstellung von oxyiminoalkansäure-derivaten
DK1347965T3 (da) Hidtil ukendte desloratidinsalte, fremgangsmåde til syntese deraf samt farmaceutiske præparater deraf
DE50201297D1 (de) Verfahren zur herstellung von 1-hydroxy-1, 1-diphosphonsäureverbindungen
ATE384067T1 (de) Verfahren zur herstellung von 3-cephemderivaten
HRP20020864A2 (en) Cyclipostins, a method for their production and the use of the same
ATE280769T1 (de) Verfahren zur herstellung von vitronectin- rezeptorantagonisten

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties