PL380866A1 - Zastosowanie smilageniny do leczenia choroby Parkinsona - Google Patents

Zastosowanie smilageniny do leczenia choroby Parkinsona

Info

Publication number: PL380866A1
Authority: PL; Poland
Prior art keywords: alzheimer disease; treating alzheimer; derivatives intended; steroid sapogenins; sapogenins
Prior art date: 1998-03-26

Application number

PL38086699A

Other languages

English (en)

Other versions

PL207723B1 (pl

Inventor

Zongqin Xia

Yaer Hu

Ian Rubin

Jonathan Brostoff

Brian Whittle

Weijun Wang

Phil Gunning

Original Assignee

Phytopharm Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-26

Filing date

1999-03-26

Publication date

2001-08-13

1998-03-26 Priority claimed from GBGB9806513.9A external-priority patent/GB9806513D0/en

1999-03-08 Priority claimed from GBGB9905275.5A external-priority patent/GB9905275D0/en

1999-03-26 Application filed by Phytopharm Plc filed Critical Phytopharm Plc

2001-08-13 Publication of PL380866A1 publication Critical patent/PL380866A1/pl

2011-01-31 Publication of PL207723B1 publication Critical patent/PL207723B1/pl

Links

INLFWQCRAJUDCR-IQVMEADQSA-N (1R,2S,4S,5'S,6R,7S,8R,9S,12S,13S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane] Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)CCCCC4CC[C@H]3[C@@H]2C1)C)[C@@H]1C)[C@]11CC[C@H](C)CO1 INLFWQCRAJUDCR-IQVMEADQSA-N 0.000 title abstract 2
208000024827 Alzheimer disease Diseases 0.000 title 1
150000003431 steroids Chemical class 0.000 title 1
230000001149 cognitive effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229930182490 saponin Natural products 0.000 abstract 1
150000007949 saponins Chemical class 0.000 abstract 1
235000017709 saponins Nutrition 0.000 abstract 1
230000003637 steroidlike Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
- G01N33/944—Acetylcholine

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Natural Medicines & Medicinal Plants (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Mycology (AREA)
Biomedical Technology (AREA)
Medical Informatics (AREA)
Botany (AREA)
Alternative & Traditional Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Pathology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Cell Biology (AREA)
General Physics & Mathematics (AREA)
Psychiatry (AREA)

PL380866A 1998-03-26 1999-03-26 Zastosowanie smilageniny do leczenia choroby Parkinsona PL207723B1 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9806513.9A GB9806513D0 (en)	1998-03-26	1998-03-26	Membrane-bound receptors
GBGB9905275.5A GB9905275D0 (en)	1999-03-08	1999-03-08	Treatment of conditions associated with membrane-bound receptors and their function
PCT/GB1999/000951 WO1999048507A2 (en)	1998-03-26	1999-03-26	Steroidal saponins for treating alzheimer's disease

Publications (2)

Publication Number	Publication Date
PL380866A1 true PL380866A1 (pl)	2001-08-13
PL207723B1 PL207723B1 (pl)	2011-01-31

Family

ID=26313369

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
PL380866A PL207723B1 (pl)	1998-03-26	1999-03-26	Zastosowanie smilageniny do leczenia choroby Parkinsona
PL99343423A PL195897B1 (pl)	1998-03-26	1999-03-26	Zastosowanie smilageniny
PL99343508A PL343508A1 (en)	1998-03-26	1999-03-26	Smilagenin and anzurogenin-d and their use

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
PL99343423A PL195897B1 (pl)	1998-03-26	1999-03-26	Zastosowanie smilageniny
PL99343508A PL343508A1 (en)	1998-03-26	1999-03-26	Smilagenin and anzurogenin-d and their use

Country Status (27)

Country	Link
US (2)	US6812213B2 (pl)
EP (3)	EP1066033B1 (pl)
JP (4)	JP3768100B2 (pl)
KR (6)	KR101092050B1 (pl)
CN (3)	CN1209112C (pl)
AT (3)	ATE507834T1 (pl)
AU (2)	AU748138B2 (pl)
BR (2)	BR9909109A (pl)
CA (2)	CA2325634A1 (pl)
CY (1)	CY1105653T1 (pl)
DE (3)	DE69933016T2 (pl)
DK (2)	DK1719512T3 (pl)
ES (2)	ES2257042T3 (pl)
GB (1)	GB2335599B (pl)
HR (2)	HRP20000637A2 (pl)
HU (2)	HUP0103654A2 (pl)
ID (2)	ID26989A (pl)
IL (4)	IL138664A0 (pl)
IS (2)	IS5637A (pl)
MX (1)	MXPA00009437A (pl)
NO (4)	NO20004803L (pl)
NZ (1)	NZ507355A (pl)
PL (3)	PL207723B1 (pl)
PT (1)	PT1066042E (pl)
RU (1)	RU2297228C2 (pl)
TR (2)	TR200002773T2 (pl)
WO (2)	WO1999048482A2 (pl)

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GB9923076D0 (en) *	1999-09-29	1999-12-01	Phytopharm Plc	Sapogenin derivatives and their use
KR101092050B1 (ko) *	1998-03-26	2011-12-12	파이토팜 피엘씨	알츠하이머병을 치료하기 위한 스밀라게닌 및 안주로게닌-ｄ
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GB0409567D0 (en) *	2004-04-28	2004-06-02	Phytopharm Plc	Chemical compounds
EP1809298A4 (en) *	2004-10-14	2008-06-18	Univ Georgetown	NEUROPROTECTIVE PHARMACEUTICAL SPIROSTENOL COMPOSITIONS
GB0424528D0 (en)	2004-11-05	2004-12-08	Phytopharm Plc	Chemical compounds
GB0512726D0 (en) *	2005-06-22	2005-07-27	Btg Int Ltd	Multiple sclerosis therapy and diagnosis
GB0513888D0 (en) *	2005-07-06	2005-08-10	Btg Int Ltd	Core 2 GLCNAC-T Inhibitors II
GB0513883D0 (en) *	2005-07-06	2005-08-10	Btg Int Ltd	Diagnosis of Atherosclerosis
KR100779179B1 (ko) *	2006-05-19	2007-11-28	충북대학교 산학협력단	토복령의 메탄올 추출물을 함유하는 뇌신경 보호 또는퇴행성뇌질환 예방 또는 치료제
JP2009256243A (ja) *	2008-04-17	2009-11-05	Noevir Co Ltd	保湿剤、抗老化剤、抗酸化剤、皮膚外用剤及び機能性経口組成物
US8217165B2 (en)	2008-06-17	2012-07-10	Pawan Kumar Goel	Process for the extraction of furostanolic saponins from fenugreek seeds
KR101027384B1 (ko) *	2009-06-29	2011-04-11	에이디엠이십일 주식회사	플랫와이퍼블레이드와 와이퍼아암의 연결장치
BRPI1005372A2 (pt)	2009-01-24	2018-03-06	Phytopharm Plc	metodo de indução da homeostase- regulada de fatores neurotroficos agente; composição; e; uso de um ou mais agentes selecionados de saponinas esteroidais de a/b-cis furostano, furosteno espirostano e espirosteno, e as suas formas de eter, cetona e glicosiladas
WO2012010896A1 (en)	2010-07-20	2012-01-26	Phytopharm Plc	Treatment of l-dopa, dopamine agonist and/or dopamine enhancer induced disorders
TWI422378B (zh) *	2010-11-18	2014-01-11	Univ Chung Shan Medical	使用薯蕷皂素來改善與停經期症候群有關聯的認知缺陷
CN102389438A (zh) *	2011-06-30	2012-03-28	北京师范大学	黄芪甲苷的应用
US20150126464A1 (en) *	2013-01-21	2015-05-07	Resilio Company Limited	Therapeutic drug and therapeutic method for neurological diseases including alzheimer's disease associated with 1,25d3-marrs
MX2017003554A (es) *	2014-09-16	2017-06-30	Brocia Robert	Bebidas energeticas y otros adyuvantes nutricionales derivados de espiritus destilados a base de agave.
KR101777920B1 (ko) *	2015-07-27	2017-09-14	재단법인 지능형 바이오 시스템 설계 및 합성 연구단	진세노사이드 f1을 포함하는 아밀로이드 플라크 제거용 조성물
CN105168785A (zh) *	2015-10-08	2015-12-23	湖北民族学院	一种治疗阿尔茨海默病的中药制剂及制备方法
EP3572085A1 (en)	2018-05-25	2019-11-27	Neuro-Sys	Synergestic combination composition comprising a steroidal saponin, a first polyphenolic compound and optionnaly a second polyphenolic compound
CN108514603B (zh) *	2018-06-28	2021-12-28	佳木斯大学	一种治疗强直型帕金森病的中药组合物及其制备方法
KR102028730B1 (ko)	2019-05-22	2019-10-04	(주)클래시스	집속초음파 기술을 이용한 지모 추출물의 제조방법 및 이로부터 수득된 지모 추출물
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1999
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Publication number	Publication date
MXPA00009437A (es)	2002-05-06
NO20004803L (no)	2000-11-27
GB2335599A (en)	1999-09-29
CA2325634A1 (en)	1999-09-30
HUP0101693A2 (hu)	2001-12-28
WO1999048482A3 (en)	2000-11-23
RU2297228C2 (ru)	2007-04-20
KR100632052B1 (ko)	2006-10-04
TR200002774T2 (tr)	2001-06-21
IS5637A (is)	2000-09-25
JP3768100B2 (ja)	2006-04-19
ID26781A (id)	2001-02-08
PT1066042E (pt)	2006-12-29
US6812213B2 (en)	2004-11-02
CA2325633A1 (en)	1999-09-30
DE69929177T2 (de)	2006-08-24
CN1302208A (zh)	2001-07-04
KR20010042190A (ko)	2001-05-25
IL174991A0 (en)	2006-08-20
WO1999048482A2 (en)	1999-09-30
GB9907100D0 (en)	1999-05-19
EP1066042B1 (en)	2006-08-30
HK1033742A1 (en)	2001-09-21
CN1679591A (zh)	2005-10-12
US20020193317A1 (en)	2002-12-19
CA2325633C (en)	2009-01-20
JP2002507572A (ja)	2002-03-12
NO20004804D0 (no)	2000-09-26
ID26989A (id)	2001-02-22
IL138663A0 (en)	2001-10-31
IL138663A (en)	2006-08-01
KR20090007505A (ko)	2009-01-16
DE69943415D1 (de)	2011-06-16
CN100377714C (zh)	2008-04-02
AU748138B2 (en)	2002-05-30
BR9909110A (pt)	2000-12-12
TR200002773T2 (tr)	2001-11-21
HRP20000637A2 (en)	2001-04-30
JP2004224797A (ja)	2004-08-12
BR9909109A (pt)	2000-12-12
KR20090009997A (ko)	2009-01-23
KR100713311B1 (ko)	2007-05-04
WO1999048507A3 (en)	1999-11-25
DE69933016D1 (de)	2006-10-12
NO20004804L (no)	2000-11-09
RU2004123463A (ru)	2006-01-27
DE69929177D1 (de)	2006-02-02
AU3157499A (en)	1999-10-18
DK1066042T3 (da)	2006-12-18
EP1066042A2 (en)	2001-01-10
ES2272060T3 (es)	2007-04-16
DK1719512T3 (da)	2011-08-15
ATE507834T1 (de)	2011-05-15
CN1301166A (zh)	2001-06-27
KR20070117001A (ko)	2007-12-11
NZ507355A (en)	2004-02-27
KR20010042205A (ko)	2001-05-25
AU3158199A (en)	1999-10-18
EP1719512A2 (en)	2006-11-08
EP1719512B1 (en)	2011-05-04
US20060182817A1 (en)	2006-08-17
GB2335599B (en)	2001-08-01
PL343508A1 (en)	2001-08-27
EP1066033B1 (en)	2005-12-28
HRP20000638A2 (en)	2001-04-30
HUP0101693A3 (en)	2002-08-28
NO20004803D0 (no)	2000-09-26
HUP0103654A2 (hu)	2002-02-28
ES2257042T3 (es)	2006-07-16
NO20083993L (no)	2000-09-11
DE69933016T2 (de)	2007-03-29
ATE314057T1 (de)	2006-01-15
CN1209112C (zh)	2005-07-06
HK1091417A1 (en)	2007-01-19
WO1999048507A2 (en)	1999-09-30
PL207723B1 (pl)	2011-01-31
JP2003524581A (ja)	2003-08-19
IL138664A0 (en)	2001-10-31
NO20085251L (no)	2000-11-09
EP1066033A1 (en)	2001-01-10
IS5638A (is)	2000-09-25
PL195897B1 (pl)	2007-11-30
CY1105653T1 (el)	2010-12-22
EP1719512A3 (en)	2007-04-11
JP2004217666A (ja)	2004-08-05
KR101092050B1 (ko)	2011-12-12
KR20070007214A (ko)	2007-01-12
PL343423A1 (en)	2001-08-13
HK1033903A1 (en)	2001-10-05
ATE337788T1 (de)	2006-09-15
CN1198622C (zh)	2005-04-27

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BR0308788A (pt)	2005-01-11	Processos terapêuticos e usos de sapogeninas e seus derivados
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TW200833344A (en)	2008-08-16	Therapeutic methods and uses of sapogenins and their derivatives