PL3830132T3 - Humanizowane przeciwciała przeciwko psma - Google Patents

Humanizowane przeciwciała przeciwko psma

Info

Publication number
PL3830132T3
PL3830132T3 PL19745146.1T PL19745146T PL3830132T3 PL 3830132 T3 PL3830132 T3 PL 3830132T3 PL 19745146 T PL19745146 T PL 19745146T PL 3830132 T3 PL3830132 T3 PL 3830132T3
Authority
PL
Poland
Prior art keywords
psma
humanized antibodies
humanized
antibodies
Prior art date
Application number
PL19745146.1T
Other languages
English (en)
Inventor
Torsten HECHLER
Andreas Pahl
Original Assignee
Heidelberg Pharma Research Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heidelberg Pharma Research Gmbh filed Critical Heidelberg Pharma Research Gmbh
Publication of PL3830132T3 publication Critical patent/PL3830132T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cell Biology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL19745146.1T 2018-07-31 2019-07-30 Humanizowane przeciwciała przeciwko psma PL3830132T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18186591 2018-07-31
PCT/EP2019/070407 WO2020025564A1 (en) 2018-07-31 2019-07-30 Humanized antibodies against psma

Publications (1)

Publication Number Publication Date
PL3830132T3 true PL3830132T3 (pl) 2023-04-17

Family

ID=63259376

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19745146.1T PL3830132T3 (pl) 2018-07-31 2019-07-30 Humanizowane przeciwciała przeciwko psma

Country Status (26)

Country Link
US (1) US11976131B2 (pl)
EP (1) EP3830132B1 (pl)
JP (1) JP7586399B2 (pl)
KR (1) KR102927925B1 (pl)
CN (1) CN112533956B (pl)
AR (1) AR115288A1 (pl)
AU (1) AU2019312801B2 (pl)
BR (1) BR112021001237A2 (pl)
CA (1) CA3104800A1 (pl)
CL (1) CL2021000146A1 (pl)
CO (1) CO2021000386A2 (pl)
DK (1) DK3830132T5 (pl)
ES (1) ES2934963T3 (pl)
FI (1) FI3830132T3 (pl)
HR (1) HRP20230115T1 (pl)
HU (1) HUE061078T2 (pl)
IL (1) IL279823B2 (pl)
LT (1) LT3830132T (pl)
MX (1) MX428228B (pl)
PL (1) PL3830132T3 (pl)
PT (1) PT3830132T (pl)
RS (1) RS63943B1 (pl)
SG (1) SG11202100607RA (pl)
SI (1) SI3830132T1 (pl)
WO (1) WO2020025564A1 (pl)
ZA (1) ZA202008095B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016089862A1 (en) * 2014-12-01 2016-06-09 The Trustees Of The University Of Pennsylvania Dna antibody constructs and method of using same
WO2020216947A1 (en) 2019-04-24 2020-10-29 Heidelberg Pharma Research Gmbh Amatoxin antibody-drug conjugates and uses thereof
CN116744969A (zh) 2020-11-04 2023-09-12 海德堡医药研究有限责任公司 用于癌症疗法的包含免疫检查点抑制剂与抗体-鹅膏毒素缀合物的组合的组合物
WO2023026235A1 (en) * 2021-08-27 2023-03-02 Janssen Biotech, Inc. Anti-psma antibodies and uses thereof
WO2023194539A1 (en) 2022-04-07 2023-10-12 Heidelberg Pharma Research Gmbh Methods of improving the therapeutic index of amatoxin-antibody conjugates
TW202442689A (zh) 2023-03-03 2024-11-01 美商亞森諾生物科學公司 靶向psma及ca9之系統
WO2024189048A1 (en) 2023-03-13 2024-09-19 Heidelberg Pharma Research Gmbh Subcutaneously administered antibody-drug conjugates for use in cancer treatment

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
DE69735294T2 (de) 1996-03-25 2006-09-21 Medarex Inc. Spezifische monoklonale antikörper für die extrazelluläre domäne von protasta-spezifischem membranantigen
US6107090A (en) 1996-05-06 2000-08-22 Cornell Research Foundation, Inc. Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains
ES2277846T3 (es) 1999-07-29 2007-08-01 Medarex, Inc. Anticuerpos monoclonales humanos para antigeno prostatico especifico.
US7666414B2 (en) 2001-06-01 2010-02-23 Cornell Research Foundation, Inc. Methods for treating prostate cancer using modified antibodies to prostate-specific membrane antigen
US7462697B2 (en) * 2004-11-08 2008-12-09 Epitomics, Inc. Methods for antibody engineering
EP1726650A1 (en) 2005-05-27 2006-11-29 Universitätsklinikum Freiburg Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen
DE202007018529U1 (de) 2007-07-07 2008-12-04 Chamalow S.A. Implantierbarer Funkfrequenzdefibrillator R.F.
MX2011003502A (es) * 2008-10-01 2011-09-01 Micromet Ag Anticuerpo de cadena sencilla biespecifica de psmaxcd3 especifico a traves de especies.
JP2012505654A (ja) * 2008-10-14 2012-03-08 ヤンセン バイオテツク,インコーポレーテツド 抗体をヒト化及び親和性成熟する方法
TWI653333B (zh) * 2010-04-01 2019-03-11 安進研究(慕尼黑)有限責任公司 跨物種專一性之PSMAxCD3雙專一性單鏈抗體
EP3587454A1 (en) * 2018-06-27 2020-01-01 Albert-Ludwigs-Universität Freiburg Chimeric antigen receptors that bind to prostate specific membrane antigen

Also Published As

Publication number Publication date
LT3830132T (lt) 2023-02-10
DK3830132T5 (da) 2024-08-19
ES2934963T3 (es) 2023-02-28
RS63943B1 (sr) 2023-02-28
JP7586399B2 (ja) 2024-11-19
SG11202100607RA (en) 2021-02-25
KR20210039389A (ko) 2021-04-09
WO2020025564A1 (en) 2020-02-06
FI3830132T3 (fi) 2023-01-13
IL279823A (en) 2021-03-01
EP3830132A1 (en) 2021-06-09
KR102927925B1 (ko) 2026-02-13
CN112533956B (zh) 2025-05-06
CL2021000146A1 (es) 2021-07-30
AR115288A1 (es) 2020-12-16
CO2021000386A2 (es) 2021-07-19
SI3830132T1 (sl) 2023-03-31
ZA202008095B (en) 2023-09-27
BR112021001237A2 (pt) 2021-04-27
CA3104800A1 (en) 2020-02-06
MX2021000783A (es) 2021-03-31
HRP20230115T1 (hr) 2023-06-09
IL279823B2 (en) 2026-02-01
PT3830132T (pt) 2023-01-05
MX428228B (es) 2025-11-13
US11976131B2 (en) 2024-05-07
JP2021532778A (ja) 2021-12-02
US20230250189A1 (en) 2023-08-10
IL279823B1 (en) 2025-10-01
EP3830132B1 (en) 2022-11-23
DK3830132T3 (da) 2023-01-02
AU2019312801A1 (en) 2021-03-11
CN112533956A (zh) 2021-03-19
AU2019312801B2 (en) 2025-09-11
HUE061078T2 (hu) 2023-05-28

Similar Documents

Publication Publication Date Title
IL282668A (en) Humanized antibodies against c-kit
KR102763158B9 (ko) 최적화된 항tl1a 항체
IL272227A (en) Anti-tigit antibodies
IL269405A (en) Anti-sirp alpha antibodies
IL268620A (en) Anti-lag3 antibodies
EP3532489A4 (en) ANTI-TL1A NEUTRALIZING MONOCLONAL ANTIBODIES
DK3625259T3 (da) Anti-sirpalpha-antistoffer
EP3661558A4 (en) ANTI-IL1RAP ANTIBODIES
EP3797122A4 (en) Anti-ror antibody constructs
EP3569709A4 (en) ANTI-GPC3 ANTIBODIES
EP3941944A4 (en) BISPECIFIC CLAUDIN-6 ANTIBODIES
IL281428A (en) Chimeric antigen receptor
EP3691447A4 (en) ANTI-TRANSTHYRETINE ANTIBODY
KR20180085002A (ko) 인간화된 항-cll-1 항체
DK3334457T3 (da) Humaniserede anti-CCR7-receptorantistoffer
DK3452513T3 (da) Humaniserede anti-il-ir3-antistoffer
DK3606961T3 (da) Garp-tgf-beta-antistoffer
EP3763743A4 (en) BISPECIFIC ANTIBODY
IL276836A (en) Cd83-binding chimeric antigen receptors
EP4081547A4 (en) Novel anti-fgfr2b antibodies
EP3487518A4 (en) HUMANIZED MONOCLONAL ANTIBODIES TARGETING VE-PTP (HPTP-SS)
DK3830132T5 (da) Humaniserede antistoffer mod psma
EP3806903A4 (en) CD79A CHIMERIC ANTIGEN RECEPTORS
PL3474904T3 (pl) Otrzymywanie przeciwciał monoklonalnych znakowanych 212pb
IL284367A (en) Monoclonal antibodies that bind specifically to human trbv9