PL383422A1 - Analogi 12-aryloprostaglandyny - Google Patents

Analogi 12-aryloprostaglandyny

Info

Publication number
PL383422A1
PL383422A1 PL383422A PL38342205A PL383422A1 PL 383422 A1 PL383422 A1 PL 383422A1 PL 383422 A PL383422 A PL 383422A PL 38342205 A PL38342205 A PL 38342205A PL 383422 A1 PL383422 A1 PL 383422A1
Authority
PL
Poland
Prior art keywords
prostaglandin analogs
aryl
aryl prostaglandin
analogs
prostaglandin
Prior art date
Application number
PL383422A
Other languages
English (en)
Other versions
PL216197B1 (pl
Inventor
Yariv Donde
Jeremiah H. Nguyen
Original Assignee
Allergan, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan, Inc. filed Critical Allergan, Inc.
Publication of PL383422A1 publication Critical patent/PL383422A1/pl
Publication of PL216197B1 publication Critical patent/PL216197B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
PL383422A 2004-12-10 2005-12-08 Analog 12-aryloprostaglandyny, jego zastosowanie w medycynie i zawierająca go okulistycznie dopuszczalna kompozycja ciekła PL216197B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/009,298 US7091231B2 (en) 2004-12-10 2004-12-10 12-Aryl prostaglandin analogs

Publications (2)

Publication Number Publication Date
PL383422A1 true PL383422A1 (pl) 2008-03-17
PL216197B1 PL216197B1 (pl) 2014-03-31

Family

ID=36578246

Family Applications (1)

Application Number Title Priority Date Filing Date
PL383422A PL216197B1 (pl) 2004-12-10 2005-12-08 Analog 12-aryloprostaglandyny, jego zastosowanie w medycynie i zawierająca go okulistycznie dopuszczalna kompozycja ciekła

Country Status (20)

Country Link
US (3) US7091231B2 (pl)
EP (1) EP1819670B1 (pl)
JP (1) JP5342142B2 (pl)
KR (1) KR101367553B1 (pl)
CN (1) CN101107225B (pl)
AR (1) AR052264A1 (pl)
AU (1) AU2005314000B2 (pl)
BR (1) BRPI0518642A2 (pl)
CA (1) CA2589864C (pl)
DK (1) DK1819670T3 (pl)
ES (1) ES2394838T3 (pl)
IL (1) IL183360A (pl)
MX (1) MX2007006690A (pl)
NO (1) NO20072662L (pl)
NZ (1) NZ555352A (pl)
PL (1) PL216197B1 (pl)
RU (1) RU2439055C2 (pl)
TW (1) TWI392666B (pl)
WO (1) WO2006063179A1 (pl)
ZA (1) ZA200704087B (pl)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
US8673341B2 (en) 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US7674786B2 (en) * 2005-05-06 2010-03-09 Allergan, Inc. Therapeutic β-lactams
WO2007005176A1 (en) * 2005-06-29 2007-01-11 Allergan, Inc. Pyrrolidinones for the treatment of glaucoma and ocular hypertension
US7585895B2 (en) * 2005-12-06 2009-09-08 Allergan, Inc. Therapeutic substituted cyclopentanes
US7427685B2 (en) * 2005-12-06 2008-09-23 Allergan, Inc. Therapeutic substituted cyclopentanes
US7592364B2 (en) * 2006-02-28 2009-09-22 Allergan, Inc. Substituted gamma lactams as therapeutic agents
WO2007115103A1 (en) 2006-03-29 2007-10-11 Catholic Healthcare West Microburst electrical stimulation of cranial nerves for the treatment of medical conditions
US20090016981A1 (en) * 2006-05-03 2009-01-15 Allergan, Inc. Therapeutic compounds
US7491844B2 (en) * 2006-05-04 2009-02-17 Allergan, Inc. Therapeutic cyclopentane derivatives
US7476755B2 (en) 2006-05-04 2009-01-13 Allergan, Inc. Therapeutic compounds
US7547727B2 (en) * 2006-05-22 2009-06-16 Allergan, Inc. Therapeutic cyclopentane derivatives
WO2008028032A2 (en) * 2006-09-01 2008-03-06 Allergan, Inc. Therapeutic substituted hydantoins and related compounds
US7429671B2 (en) * 2006-12-06 2008-09-30 Air Products And Chemicals, Inc. Process for the fluorination of boron hydrides
CA2675632A1 (en) * 2007-01-22 2008-07-31 Allergan, Inc. Substituted arylcyclopentenes as therapeutic agents
CA2675981A1 (en) 2007-01-22 2008-07-31 Allergan, Inc. Thiophene derivatives useful as ocular hypotensive agents
US8722726B2 (en) * 2007-01-25 2014-05-13 Allergan, Inc. Substituted arylcyclopentenes as therapeutic agents
US9365485B2 (en) 2007-01-25 2016-06-14 Allergan, Inc. Substituted arylcyclopentenes as therapeutic agents
US8377984B2 (en) * 2008-01-29 2013-02-19 Allergan, Inc. Substituted gamma lactams as therapeutic agents
CA2676291C (en) * 2007-01-31 2017-11-28 Allergan, Inc. Substituted gamma lactams as therapeutic agents
NZ598945A (en) * 2007-02-15 2013-08-30 Allergan Inc Gamma-lactams for the treatment of glaucoma or elevated intraocular pressure
US7589213B2 (en) * 2007-04-27 2009-09-15 Old David W Therapeutic substituted lactams
BRPI0812385A2 (pt) * 2007-05-23 2019-09-24 Allergan Inc lactamas cíclicas para o tratamento de glaucoma ou pressão intraocular elevada
AU2008302667B2 (en) * 2007-06-15 2014-07-10 Board Of Regents, The University Of Texas System Methods and compositions to inhibit edema factor and adenylyl cyclase
US7662850B2 (en) * 2007-07-13 2010-02-16 Allergan, Inc. Therapeutic substituted chlorocyclopentanols
US7947732B2 (en) 2007-07-13 2011-05-24 Allergan, Inc. Therapeutic substituted chlorocyclopentanols
US20090062361A1 (en) * 2007-08-30 2009-03-05 Allergan, Inc. Therapeutic hydantoins
MX2010005105A (es) * 2007-11-09 2010-05-27 Allergan Inc Ciclopentanos substituidos que comprenden actividad de prostaglandina.
JP5566902B2 (ja) * 2007-11-29 2014-08-06 アラーガン インコーポレイテッド プロスタグランジン活性を有する置換シクロペンタン類
US8063033B2 (en) * 2008-01-18 2011-11-22 Allergan, Inc. Therapeutic beta-lactams
US7956051B2 (en) * 2008-01-24 2011-06-07 Allergan, Inc. Therapeutic amides and related compounds
US8455547B2 (en) * 2008-02-05 2013-06-04 Allergan, Inc. Substituted cyclopentanes having prostaglandin activity
US8633310B2 (en) * 2008-02-19 2014-01-21 Allergan, Inc. Therapeutic substituted lactams
US8440819B2 (en) * 2008-02-22 2013-05-14 Allergan, Inc. Therapeutic substituted beta-lactams
US8487091B2 (en) * 2008-03-04 2013-07-16 Allergan, Inc. Substituted cyclopentanes having prostaglandin activity
US7964596B2 (en) * 2008-03-07 2011-06-21 Allergan, Inc. Therapeutic compounds
US20090233921A1 (en) * 2008-03-11 2009-09-17 Allergan, Inc. Therapeutic cyclopentane derivatives
US7960379B2 (en) * 2008-03-14 2011-06-14 Allergan, Inc. Therapeutic compounds
US8198318B2 (en) * 2008-03-18 2012-06-12 Allergen, Inc. Therapeutic amides
US7705001B2 (en) * 2008-03-18 2010-04-27 Allergan, Inc Therapeutic substituted gamma lactams
US7732443B2 (en) * 2008-03-18 2010-06-08 Yariv Donde Therapeutic substituted cyclopentanes
US7956055B2 (en) * 2008-03-25 2011-06-07 Allergan, Inc. Substituted gamma lactams as therapeutic agents
US20110152328A1 (en) * 2008-04-16 2011-06-23 Whitcup Scott M Combination Therapy For Glaucoma
BRPI0910741A2 (pt) * 2008-04-24 2015-09-29 Allergan Inc arilciclopentenos substituídos como agonistas de prostaglantina ep2
UA103616C2 (ru) * 2008-04-24 2013-11-11 Аллерган, Инк. Замещенные гамма-лактамы как терапевтические агенты
WO2009132087A1 (en) * 2008-04-24 2009-10-29 Allergan, Inc. Thiophene derivatives useful as ocular hypotensive agents
BRPI0911543A2 (pt) * 2008-04-24 2015-10-13 Allergan Inc arilciclopentenos substituídos como agentes terapêuticos
CA2731279A1 (en) 2008-04-24 2009-10-29 Allergan, Inc. Therapeutic compounds
US7964634B2 (en) * 2008-04-24 2011-06-21 Allergan, Inc. Therapeutic compounds
EP2303836A1 (en) * 2008-05-09 2011-04-06 Allergan, Inc. Therapeutic cyclopentane derivatives
US7981887B2 (en) 2008-05-09 2011-07-19 Allergan, Inc. Therapeutic compounds
JP2011519937A (ja) * 2008-05-09 2011-07-14 アラーガン インコーポレイテッド 治療用ｎ‐アリールまたはｎ‐ヘテロアリールピラゾリジンおよびピラゾリジノン誘導体
CA2724972A1 (en) * 2008-05-09 2009-11-12 Allergan, Inc. Therapeutic compounds
US7713967B2 (en) 2008-05-09 2010-05-11 Allergan, Inc. Therapeutic substituted hydantoins, and related compounds
WO2009137412A1 (en) * 2008-05-09 2009-11-12 Allergan, Inc. Therapeutic compounds
EP2285775B1 (en) * 2008-05-20 2017-03-22 Allergan, Inc. Lactams and their use in the treatment of inter alia ocular hypertension or baldness
CA2724605A1 (en) * 2008-05-27 2009-12-03 Allergan, Inc. Prostaglandin prodrugs as hypotensive agents
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
US8952051B2 (en) * 2009-11-05 2015-02-10 Allergan, Inc. Ophthalmic formulations containing substituted gamma lactams and methods for use thereof
US9090584B2 (en) * 2010-01-26 2015-07-28 Allergan, Inc. Therapeutic agents for treatment of ocular hypertension
US8299068B2 (en) 2010-01-29 2012-10-30 Allergan, Inc. Therapeutically active cyclopentanes
ES2711425T3 (es) * 2012-08-27 2019-05-03 Allergan Inc Espesamiento de la córnea central reducido mediante el uso de profármacos de éster hidrófilos de beta-clorociclopentanos
WO2014194209A1 (en) 2013-05-31 2014-12-04 Allergan, Inc. Substituted cyclopentenes as therapeutic agents
CN105592851A (zh) 2013-09-30 2016-05-18 帕西昂Api服务公司 利用复分解反应的前列腺素和前列腺素中间体的新合成途径
ES2757798T3 (es) 2014-10-02 2020-04-30 Allergan Inc Profármacos de éster de gamma-lactamas y su uso
KR102069205B1 (ko) * 2017-08-09 2020-01-22 연성정밀화학(주) 라타노프로스틴 부노드의 제조 방법 및 그를 위한 중간체

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4066834A (en) * 1974-01-24 1978-01-03 Miles Laboratories, Inc. Cycloalkenyl analogues of prostaglandins E
US4166452A (en) * 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4168452A (en) * 1976-06-10 1979-09-18 Zenith Radio Corporation Tetrode section for a unitized, three-beam electron gun having an extended field main focus lens
US4256108A (en) * 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
DE3100578A1 (de) * 1980-01-25 1982-02-11 Farmitalia Carlo Erba S.p.A., 20159 Milano Isoxazolyl- und isoxazolinyl-prostaglandine, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische und veterinaermedizinische mittel
US4265874A (en) * 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
DE4330177A1 (de) * 1993-08-31 1995-03-02 Schering Ag Neue 9-Chlor-prostaglandin-derivate
US5462968A (en) * 1994-01-19 1995-10-31 Allergan, Inc. EP2 -receptor agonists as agents for lowering intraocular pressure
US5902726A (en) * 1994-12-23 1999-05-11 Glaxo Wellcome Inc. Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma
US5698598A (en) 1995-08-04 1997-12-16 Allergan EP2 -receptor agonists as agents for lowering intraocular pressure
US6090874A (en) * 1995-12-13 2000-07-18 Zeon Chemicals L.P. High clarity carboxylated nitrile rubber
JP3162668B2 (ja) * 1997-02-04 2001-05-08 小野薬品工業株式会社 ω−シクロアルキル−プロスタグランジンＥ２誘導体
AU7349298A (en) * 1997-06-23 1999-01-04 Pfizer Inc. Prostaglandin agonists
SE9702706D0 (sv) * 1997-07-11 1997-07-11 Pharmacia & Upjohn Ab Prostaglandin derivatives devoid of side-effects for the treatment of glaucoma
US6090847A (en) * 1997-11-21 2000-07-18 Allergan Sales, Inc. EP2 -receptor agonists as neuroprotective agents for the eye
US6437146B1 (en) * 1998-09-25 2002-08-20 Fujisawa Pharmaceutical Co., Ltd. Oxazole compounds as prostaglandin e2 agonists or antagonists
JP2001527063A (ja) * 1998-12-24 2001-12-25 小野薬品工業株式会社 ω−シクロアルキル−プロスタグランジンＥ２誘導体
WO2002012243A2 (en) * 2000-08-09 2002-02-14 Boehringer Ingelheim Pharmaceuticals, Inc. SYNTHESIS OF (R)-3-(4-BROMOBENZYL)-1-(3,5-DICHLOROPHENYL)-5-IODO-3-METHYL-1-H-IMIDAZO[1,2-a]IMIDAZOL-2-ONE
NZ532519A (en) * 2001-11-05 2006-11-30 Allergan Inc Omega-cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
US6747037B1 (en) * 2003-06-06 2004-06-08 Allergan, Inc. Piperidinyl prostaglandin E analogs
GB0329620D0 (en) 2003-12-22 2004-01-28 Pharmagene Lab Ltd EP2 receptor agonists
EP1856042B1 (en) * 2005-03-10 2012-06-27 Allergan, Inc. Substituted gamma lactams as therapeutic agents
US7592364B2 (en) * 2006-02-28 2009-09-22 Allergan, Inc. Substituted gamma lactams as therapeutic agents
EP1996546B1 (en) * 2006-03-20 2014-11-26 Allergan, Inc. Substituted gamma lactams as prostaglandin ep2 agonists

Also Published As

Publication number Publication date
US7091231B2 (en) 2006-08-15
JP5342142B2 (ja) 2013-11-13
NZ555352A (en) 2011-01-28
JP2008523088A (ja) 2008-07-03
NO20072662L (no) 2007-09-04
US20060148894A1 (en) 2006-07-06
CA2589864A1 (en) 2006-06-15
RU2007120520A (ru) 2009-01-20
AR052264A1 (es) 2007-03-07
TWI392666B (zh) 2013-04-11
RU2439055C2 (ru) 2012-01-10
ZA200704087B (en) 2008-09-25
HK1114832A1 (en) 2008-11-14
US20100317872A1 (en) 2010-12-16
US7799821B2 (en) 2010-09-21
IL183360A0 (en) 2007-09-20
AU2005314000B2 (en) 2012-06-14
MX2007006690A (es) 2007-08-14
DK1819670T3 (da) 2012-09-17
WO2006063179A1 (en) 2006-06-15
AU2005314000A1 (en) 2006-06-15
TW200633966A (en) 2006-10-01
CA2589864C (en) 2015-02-03
BRPI0518642A2 (pt) 2008-12-02
US20060205800A1 (en) 2006-09-14
ES2394838T3 (es) 2013-02-06
EP1819670B1 (en) 2012-08-08
KR101367553B1 (ko) 2014-03-14
KR20070086001A (ko) 2007-08-27
EP1819670A1 (en) 2007-08-22
CN101107225A (zh) 2008-01-16
IL183360A (en) 2010-12-30
CN101107225B (zh) 2012-11-28
US8044092B2 (en) 2011-10-25
PL216197B1 (pl) 2014-03-31

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