PL3837256T3 - Związki i kompozycje mocznika jako inhibitory smarca2/brm-atpazy - Google Patents

Związki i kompozycje mocznika jako inhibitory smarca2/brm-atpazy

Info

Publication number
PL3837256T3
PL3837256T3 PL19779145.2T PL19779145T PL3837256T3 PL 3837256 T3 PL3837256 T3 PL 3837256T3 PL 19779145 T PL19779145 T PL 19779145T PL 3837256 T3 PL3837256 T3 PL 3837256T3
Authority
PL
Poland
Prior art keywords
smarca2
brm
compositions
urea compounds
atpase inhibitors
Prior art date
Application number
PL19779145.2T
Other languages
English (en)
Inventor
Christopher Adair
Julien Papillon
Katsumasa Nakajima
Troy Douglas SMITH
Rukundo Ntaganda
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PL3837256T3 publication Critical patent/PL3837256T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL19779145.2T 2018-08-17 2019-08-12 Związki i kompozycje mocznika jako inhibitory smarca2/brm-atpazy PL3837256T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862765138P 2018-08-17 2018-08-17
PCT/IB2019/056847 WO2020035779A1 (en) 2018-08-17 2019-08-12 Urea compounds and compositions as smarca2/brm atpase inhibitors

Publications (1)

Publication Number Publication Date
PL3837256T3 true PL3837256T3 (pl) 2023-07-10

Family

ID=68072895

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19779145.2T PL3837256T3 (pl) 2018-08-17 2019-08-12 Związki i kompozycje mocznika jako inhibitory smarca2/brm-atpazy

Country Status (21)

Country Link
US (2) US11958846B2 (pl)
EP (2) EP4219488A1 (pl)
JP (1) JP7328323B2 (pl)
KR (1) KR20210047313A (pl)
CN (2) CN112585136B (pl)
AU (1) AU2019322325B2 (pl)
BR (1) BR112021002632A2 (pl)
CA (1) CA3107097A1 (pl)
CY (1) CY1126039T1 (pl)
DK (1) DK3837256T3 (pl)
ES (1) ES2946060T3 (pl)
FI (1) FI3837256T3 (pl)
HR (1) HRP20230477T1 (pl)
HU (1) HUE061963T2 (pl)
LT (1) LT3837256T (pl)
MX (1) MX2021001804A (pl)
PL (1) PL3837256T3 (pl)
PT (1) PT3837256T (pl)
RS (1) RS64238B1 (pl)
SI (1) SI3837256T1 (pl)
WO (1) WO2020035779A1 (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017087885A1 (en) 2015-11-19 2017-05-26 Dana-Farber Cancer Institute, Inc. Methods of identifying compounds that interfere with erg-driven misguidance of baf complexes in tmprss2-erg driven prostate cancers
US11497752B2 (en) 2018-01-30 2022-11-15 Foghorn Therapeutics Inc. Compounds and uses thereof
PT3837256T (pt) * 2018-08-17 2023-05-23 Novartis Ag Compostos e composições de ureia como inibidores de smarca2/brm-atpase
WO2020081588A1 (en) 2018-10-17 2020-04-23 Dana-Farber Cancer Institute, Inc. Swi/snf family chromatin remodeling complexes and uses thereof
US12509453B2 (en) 2019-01-29 2025-12-30 Foghorn Therapeutics Inc. BRM/BRG1 inhibitors and uses thereof
US12384776B2 (en) 2019-01-29 2025-08-12 Foghorn Therapeutics Inc. Compounds and uses thereof
AU2021213811A1 (en) 2020-01-29 2022-07-28 Foghorn Therapeutics Inc. Compounds and uses thereof
US12383555B2 (en) 2020-05-20 2025-08-12 Foghorn Therapeutics Inc. Methods of treating cancers
CN112979646B (zh) * 2021-03-08 2022-01-14 北京富龙康泰生物技术有限公司 一种咪唑并吡啶类衍生物
US12606553B2 (en) 2021-03-09 2026-04-21 Foghorn Therapeutics Inc. Crystalline forms, compositions containing same, and methods of their use
EP4734993A2 (en) * 2023-06-30 2026-05-06 Dana-Farber Cancer Institute, Inc. Methods for sensitizing drug-resistant cancer cells

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2779780A (en) 1955-03-01 1957-01-29 Du Pont 1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
US2871243A (en) * 1956-10-26 1959-01-27 May & Baker Ltd 5-amino-3-methyl-isothiazole and process
AUPP003197A0 (en) 1997-09-03 1997-11-20 Fujisawa Pharmaceutical Co., Ltd. New heterocyclic compounds
GB9823873D0 (en) * 1998-10-30 1998-12-30 Pharmacia & Upjohn Spa 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents
EP1143957A3 (en) 1998-12-16 2002-02-27 Warner-Lambert Company Treatment of arthritis with mek inhibitors
US7217722B2 (en) * 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
JP3811775B2 (ja) 2000-07-19 2006-08-23 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー ４−ヨードフェニルアミノベンズヒドロキサム酸の酸素化エステル
US20020173507A1 (en) 2000-08-15 2002-11-21 Vincent Santora Urea compounds and methods of uses
ATE442362T1 (de) 2001-05-24 2009-09-15 Leo Pharma As Pyridylcyanoguanidin verbindungen
CN1653059A (zh) 2002-03-08 2005-08-10 卫材株式会社 用作医药品的大环化合物
KR100984595B1 (ko) 2002-03-13 2010-09-30 어레이 바이오파마 인크. Ｍｅｋ 억제제로서의 ｎ3 알킬화 벤즈이미다졸 유도체
US20030236287A1 (en) 2002-05-03 2003-12-25 Piotrowski David W. Positive allosteric modulators of the nicotinic acetylcholine receptor
AU2003243921B2 (en) 2002-06-27 2009-05-07 Novo Nordisk A/S Aryl carbonyl derivatives as therapeutic agents
JP2007524596A (ja) 2003-02-28 2007-08-30 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 共結晶医薬組成物
WO2004085433A2 (en) 2003-03-28 2004-10-07 Pharmacia & Upjohn Company Llc Positive allosteric modulators of the nicotinic acetylcholine receptor
CA2618218C (en) 2005-07-21 2015-06-30 Ardea Biosciences, Inc. N-(arylamino)-sulfonamide inhibitors of mek
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
US8455513B2 (en) * 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
EP2205242B1 (en) 2007-09-12 2015-04-15 Genentech, Inc. Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
JP5348725B2 (ja) 2007-10-25 2013-11-20 ジェネンテック， インコーポレイテッド チエノピリミジン化合物の製造方法
RU2487131C2 (ru) 2008-03-14 2013-07-10 Оцука Фармасьютикал Ко., Лтд. Ингибитор ммр-2 и/или ммр-9
CN103880737A (zh) * 2014-02-27 2014-06-25 浙江泰达作物科技有限公司 1-(2-氯-4-吡啶基)-3-苯基脲的制备方法
US10065934B2 (en) 2014-07-17 2018-09-04 Sunshine Lake Pharma Co., Ltd. Substituted urea derivatives and pharmaceutical uses thereof
MA41598A (fr) 2015-02-25 2018-01-02 Constellation Pharmaceuticals Inc Composés thérapeutiques de pyridazine et leurs utilisations
CN105481723B (zh) 2015-04-29 2017-08-25 中国农业大学 一种非均相催化的烷基/苄基/芳基脲类化合物的制备方法
WO2018187414A1 (en) 2017-04-05 2018-10-11 The Regents Of The University Of California Inhibitors of mtor-rictor interactions
PT3837256T (pt) * 2018-08-17 2023-05-23 Novartis Ag Compostos e composições de ureia como inibidores de smarca2/brm-atpase
WO2020126968A2 (en) 2018-12-20 2020-06-25 Bayer Aktiengesellschaft Urea derivatives

Also Published As

Publication number Publication date
US20210323956A1 (en) 2021-10-21
CY1126039T1 (el) 2023-11-15
HUE061963T2 (hu) 2023-09-28
JP7328323B2 (ja) 2023-08-16
CN118666832A (zh) 2024-09-20
MX2021001804A (es) 2021-04-19
LT3837256T (lt) 2023-06-12
US12358906B2 (en) 2025-07-15
AU2019322325A1 (en) 2021-02-18
CA3107097A1 (en) 2020-02-20
WO2020035779A1 (en) 2020-02-20
US20240270738A1 (en) 2024-08-15
US11958846B2 (en) 2024-04-16
EP4219488A1 (en) 2023-08-02
RS64238B1 (sr) 2023-06-30
HRP20230477T1 (hr) 2023-07-21
PT3837256T (pt) 2023-05-23
ES2946060T3 (es) 2023-07-12
JP2021534147A (ja) 2021-12-09
CN112585136A (zh) 2021-03-30
CN112585136B (zh) 2024-06-25
KR20210047313A (ko) 2021-04-29
SI3837256T1 (sl) 2023-07-31
DK3837256T3 (da) 2023-05-30
BR112021002632A2 (pt) 2021-05-11
FI3837256T3 (fi) 2023-05-15
EP3837256A1 (en) 2021-06-23
AU2019322325B2 (en) 2022-01-20
EP3837256B1 (en) 2023-03-08

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