DK3837256T3 - Ureaforbindelser og sammensætninger som smarca2/brm-atpase-hæmmere - Google Patents

Ureaforbindelser og sammensætninger som smarca2/brm-atpase-hæmmere Download PDF

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Publication number
DK3837256T3
DK3837256T3 DK19779145.2T DK19779145T DK3837256T3 DK 3837256 T3 DK3837256 T3 DK 3837256T3 DK 19779145 T DK19779145 T DK 19779145T DK 3837256 T3 DK3837256 T3 DK 3837256T3
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DK
Denmark
Prior art keywords
smarca2
compositions
urea compounds
atpase inhibitors
brm atpase
Prior art date
Application number
DK19779145.2T
Other languages
English (en)
Inventor
Christopher Adair
Julien Papillon
Katsumasa Nakajima
Troy Douglas Smith
Rukundo Ntaganda
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK3837256T3 publication Critical patent/DK3837256T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK19779145.2T 2018-08-17 2019-08-12 Ureaforbindelser og sammensætninger som smarca2/brm-atpase-hæmmere DK3837256T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862765138P 2018-08-17 2018-08-17
PCT/IB2019/056847 WO2020035779A1 (en) 2018-08-17 2019-08-12 Urea compounds and compositions as smarca2/brm atpase inhibitors

Publications (1)

Publication Number Publication Date
DK3837256T3 true DK3837256T3 (da) 2023-05-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DK19779145.2T DK3837256T3 (da) 2018-08-17 2019-08-12 Ureaforbindelser og sammensætninger som smarca2/brm-atpase-hæmmere

Country Status (21)

Country Link
US (2) US11958846B2 (da)
EP (2) EP4219488A1 (da)
JP (1) JP7328323B2 (da)
KR (1) KR20210047313A (da)
CN (2) CN112585136B (da)
AU (1) AU2019322325B2 (da)
BR (1) BR112021002632A2 (da)
CA (1) CA3107097A1 (da)
CY (1) CY1126039T1 (da)
DK (1) DK3837256T3 (da)
ES (1) ES2946060T3 (da)
FI (1) FI3837256T3 (da)
HR (1) HRP20230477T1 (da)
HU (1) HUE061963T2 (da)
LT (1) LT3837256T (da)
MX (1) MX2021001804A (da)
PL (1) PL3837256T3 (da)
PT (1) PT3837256T (da)
RS (1) RS64238B1 (da)
SI (1) SI3837256T1 (da)
WO (1) WO2020035779A1 (da)

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US12282014B2 (en) 2015-11-19 2025-04-22 Dana-Farber Cancer Institute, Inc. Methods of identifying compounds that interfere with ERG-driven misguidance of BAF complexes in TMPRSS2-ERG driven prostate cancers
EP3746124A4 (en) 2018-01-30 2021-10-27 Foghorn Therapeutics Inc. COMPOUNDS AND THEIR USES
CN112585136B (zh) 2018-08-17 2024-06-25 诺华股份有限公司 作为smarca2/brm atp酶抑制剂的脲化合物和组合物
US12473334B2 (en) 2018-10-17 2025-11-18 Dana-Farber Cancer Institute, Inc. SWI/SNF family chromatin remodeling complexes and uses thereof
US12509453B2 (en) 2019-01-29 2025-12-30 Foghorn Therapeutics Inc. BRM/BRG1 inhibitors and uses thereof
US12384776B2 (en) 2019-01-29 2025-08-12 Foghorn Therapeutics Inc. Compounds and uses thereof
WO2021155264A1 (en) 2020-01-29 2021-08-05 Foghorn Therapeutics Inc. Compounds and uses thereof
WO2021155262A1 (en) 2020-01-29 2021-08-05 Foghorn Therapeutics Inc. Compounds and uses thereof
US12383555B2 (en) 2020-05-20 2025-08-12 Foghorn Therapeutics Inc. Methods of treating cancers
CN112979646B (zh) * 2021-03-08 2022-01-14 北京富龙康泰生物技术有限公司 一种咪唑并吡啶类衍生物
US12606553B2 (en) 2021-03-09 2026-04-21 Foghorn Therapeutics Inc. Crystalline forms, compositions containing same, and methods of their use
EP4734993A2 (en) * 2023-06-30 2026-05-06 Dana-Farber Cancer Institute, Inc. Methods for sensitizing drug-resistant cancer cells

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JP2002532415A (ja) 1998-12-16 2002-10-02 ワーナー−ランバート・カンパニー Ｍｅｋ阻害剤による関節炎の治療
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CA2744893A1 (en) 2002-06-27 2004-01-08 Novo Nordisk A/S Aryl carbonyl derivatives as glucokinase activators
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CN103880737A (zh) * 2014-02-27 2014-06-25 浙江泰达作物科技有限公司 1-(2-氯-4-吡啶基)-3-苯基脲的制备方法
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CN112585136B (zh) * 2018-08-17 2024-06-25 诺华股份有限公司 作为smarca2/brm atp酶抑制剂的脲化合物和组合物
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Also Published As

Publication number Publication date
US20240270738A1 (en) 2024-08-15
PL3837256T3 (pl) 2023-07-10
FI3837256T3 (fi) 2023-05-15
CN118666832A (zh) 2024-09-20
JP7328323B2 (ja) 2023-08-16
US20210323956A1 (en) 2021-10-21
AU2019322325B2 (en) 2022-01-20
EP3837256A1 (en) 2021-06-23
JP2021534147A (ja) 2021-12-09
HRP20230477T1 (hr) 2023-07-21
RS64238B1 (sr) 2023-06-30
SI3837256T1 (sl) 2023-07-31
AU2019322325A1 (en) 2021-02-18
CN112585136A (zh) 2021-03-30
CN112585136B (zh) 2024-06-25
LT3837256T (lt) 2023-06-12
EP4219488A1 (en) 2023-08-02
ES2946060T3 (es) 2023-07-12
HUE061963T2 (hu) 2023-09-28
WO2020035779A1 (en) 2020-02-20
BR112021002632A2 (pt) 2021-05-11
US11958846B2 (en) 2024-04-16
KR20210047313A (ko) 2021-04-29
PT3837256T (pt) 2023-05-23
EP3837256B1 (en) 2023-03-08
CA3107097A1 (en) 2020-02-20
CY1126039T1 (el) 2023-11-15
MX2021001804A (es) 2021-04-19
US12358906B2 (en) 2025-07-15

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