PL3880670T3 - Ulepszona synteza kluczowego związku pośredniego dla związku inhibitora kras g12c - Google Patents

Ulepszona synteza kluczowego związku pośredniego dla związku inhibitora kras g12c

Info

Publication number
PL3880670T3
PL3880670T3 PL19820938.9T PL19820938T PL3880670T3 PL 3880670 T3 PL3880670 T3 PL 3880670T3 PL 19820938 T PL19820938 T PL 19820938T PL 3880670 T3 PL3880670 T3 PL 3880670T3
Authority
PL
Poland
Prior art keywords
kras
inhibitor compound
key intermediate
improved synthesis
synthesis
Prior art date
Application number
PL19820938.9T
Other languages
English (en)
Inventor
Andrew Thomas PARSONS
Brian McNeil COCHRAN
IV William POWAZINIK
Marc Anthony Caporini
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of PL3880670T3 publication Critical patent/PL3880670T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/78—Benzoic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/06—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL19820938.9T 2018-11-16 2019-11-15 Ulepszona synteza kluczowego związku pośredniego dla związku inhibitora kras g12c PL3880670T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862768802P 2018-11-16 2018-11-16
PCT/US2019/061815 WO2020102730A1 (en) 2018-11-16 2019-11-15 Improved synthesis of key intermediate of kras g12c inhibitor compound

Publications (1)

Publication Number Publication Date
PL3880670T3 true PL3880670T3 (pl) 2023-10-02

Family

ID=68887130

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19820938.9T PL3880670T3 (pl) 2018-11-16 2019-11-15 Ulepszona synteza kluczowego związku pośredniego dla związku inhibitora kras g12c

Country Status (25)

Country Link
US (5) US11299491B2 (pl)
EP (2) EP3880670B1 (pl)
JP (2) JP7516029B2 (pl)
KR (2) KR20250164341A (pl)
CN (3) CN113015724B (pl)
AR (1) AR117101A1 (pl)
AU (2) AU2019381817B2 (pl)
BR (1) BR112021009384A2 (pl)
CA (1) CA3117221A1 (pl)
CL (1) CL2021001266A1 (pl)
DK (1) DK3880670T3 (pl)
EA (1) EA202191381A1 (pl)
ES (1) ES2953752T3 (pl)
FI (1) FI3880670T3 (pl)
HU (1) HUE062656T2 (pl)
IL (2) IL318601A (pl)
LT (1) LT3880670T (pl)
MA (1) MA54233A (pl)
MX (2) MX2021005598A (pl)
PL (1) PL3880670T3 (pl)
PT (1) PT3880670T (pl)
SG (1) SG11202104927QA (pl)
SI (1) SI3880670T1 (pl)
TW (1) TWI862525B (pl)
WO (1) WO2020102730A1 (pl)

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MX2021005598A (es) 2021-06-30
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US20220220112A1 (en) 2022-07-14
AU2019381817B2 (en) 2025-02-06

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