PL396946A1 - Pochodne pirazolu i kompozycje farmaceutyczne zawierające je oraz ich zastosowanie do leczenia HIV - Google Patents

Pochodne pirazolu i kompozycje farmaceutyczne zawierające je oraz ich zastosowanie do leczenia HIV

Info

Publication number: PL396946A1
Authority: PL; Poland
Prior art keywords: compositions containing; pyrazole derivatives; application; pharmaceutical compositions; compounds
Prior art date: 2001-04-10

Application number

PL396946A

Other languages

English (en)

Other versions

PL217224B1 (pl

Inventor

Lyn Howard Jones

Charles Eric Mowbray

David Anthony Price

Matthew Duncan Selby

Paul Anthony Stupple

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-10

Filing date

2002-04-04

Publication date

2012-01-02

2001-04-10 Priority claimed from GB0108999A external-priority patent/GB0108999D0/en

2001-11-15 Priority claimed from GB0127426A external-priority patent/GB0127426D0/en

2002-04-04 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2012-01-02 Publication of PL396946A1 publication Critical patent/PL396946A1/pl

2014-06-30 Publication of PL217224B1 publication Critical patent/PL217224B1/pl

Links

150000003217 pyrazoles Chemical class 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
208000030507 AIDS Diseases 0.000 abstract 2
102100034343 Integrase Human genes 0.000 abstract 2
108010092799 RNA-directed DNA polymerase Proteins 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
241000700605 Viruses Species 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
208000011580 syndromic disease Diseases 0.000 abstract 1
241001430294 unidentified retrovirus Species 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PL396946A 2001-04-10 2002-04-04 Kompozycja farmaceutyczna oraz jej zastosowanie PL217224B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB0108999A GB0108999D0 (en)	2001-04-10	2001-04-10	Pyrazole derivatives
GB0127426A GB0127426D0 (en)	2001-11-15	2001-11-15	Pyrazole derivatives

Publications (2)

Publication Number	Publication Date
PL396946A1 true PL396946A1 (pl)	2012-01-02
PL217224B1 PL217224B1 (pl)	2014-06-30

Family

ID=26245955

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
PL365026A PL216985B1 (pl)	2001-04-10	2002-04-04	Pochodne pirazolu, kompozycja farmaceutyczna zawierająca je oraz ich zastosowania
PL396946A PL217224B1 (pl)	2001-04-10	2002-04-04	Kompozycja farmaceutyczna oraz jej zastosowanie
PL398536A PL217629B1 (pl)	2001-04-10	2002-04-04	Pochodne pirazolu i kompozycje farmaceutyczne zawierające je oraz ich zastosowanie

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PL365026A PL216985B1 (pl)	2001-04-10	2002-04-04	Pochodne pirazolu, kompozycja farmaceutyczna zawierająca je oraz ich zastosowania

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL398536A PL217629B1 (pl)	2001-04-10	2002-04-04	Pochodne pirazolu i kompozycje farmaceutyczne zawierające je oraz ich zastosowanie

Country Status (42)

Country	Link
US (4)	US7109228B2 (pl)
EP (2)	EP1377556B1 (pl)
JP (1)	JP3806090B2 (pl)
KR (1)	KR100569324B1 (pl)
CN (1)	CN100408564C (pl)
AR (2)	AR037319A1 (pl)
AT (2)	ATE358669T1 (pl)
AU (1)	AU2002242926B2 (pl)
BG (1)	BG66349B1 (pl)
BR (1)	BRPI0208811B8 (pl)
CA (1)	CA2443449C (pl)
CR (1)	CR7069A (pl)
CY (2)	CY1107626T1 (pl)
CZ (1)	CZ305099B6 (pl)
DE (1)	DE60219292T2 (pl)
DK (2)	DK1762567T3 (pl)
DO (1)	DOP2002000378A (pl)
EA (1)	EA007184B1 (pl)
EE (1)	EE05400B1 (pl)
ES (2)	ES2385659T3 (pl)
GE (1)	GEP20053619B (pl)
HR (1)	HRP20030783B1 (pl)
HU (1)	HU229025B1 (pl)
IL (2)	IL157875A0 (pl)
IS (1)	IS2734B (pl)
MA (1)	MA27009A1 (pl)
ME (1)	ME00558A (pl)
MX (1)	MXPA03009380A (pl)
MY (1)	MY146669A (pl)
NO (1)	NO326518B1 (pl)
NZ (1)	NZ529403A (pl)
OA (1)	OA12501A (pl)
PA (1)	PA8543601A1 (pl)
PE (1)	PE20021056A1 (pl)
PL (3)	PL216985B1 (pl)
PT (2)	PT1377556E (pl)
RS (1)	RS51166B (pl)
SI (2)	SI1762567T1 (pl)
SK (1)	SK287858B6 (pl)
TW (1)	TWI333488B (pl)
UY (1)	UY27248A1 (pl)
WO (1)	WO2002085860A1 (pl)

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Also Published As

Publication number	Publication date
OA12501A (en)	2006-05-26
AR037319A1 (es)	2004-11-03
ME00558A (en)	2011-12-20
DE60219292D1 (de)	2007-05-16
DK1762567T3 (da)	2012-06-25
PE20021056A1 (es)	2002-12-03
GEP20053619B (en)	2005-09-26
CN1514828A (zh)	2004-07-21
HK1063781A1 (zh)	2005-01-14
PT1762567E (pt)	2012-07-16
CA2443449C (en)	2008-11-04
BG66349B1 (bg)	2013-08-30
UY27248A1 (es)	2002-11-29
AR076259A2 (es)	2011-06-01
SI1762567T1 (sl)	2012-08-31
SK287858B6 (sk)	2012-01-04
IL157875A (en)	2010-05-17
PT1377556E (pt)	2007-06-06
HUP0303735A2 (hu)	2004-03-01
DE60219292T2 (de)	2008-04-10
CN100408564C (zh)	2008-08-06
MY146669A (en)	2012-09-14
PL217224B1 (pl)	2014-06-30
WO2002085860A1 (en)	2002-10-31
SI1377556T1 (sl)	2007-08-31
CA2443449A1 (en)	2002-10-31
YU77503A (sh)	2006-05-25
US7435728B2 (en)	2008-10-14
US20030100554A1 (en)	2003-05-29
US20120029192A1 (en)	2012-02-02
PL217629B1 (pl)	2014-08-29
US20090215712A1 (en)	2009-08-27
ES2385659T3 (es)	2012-07-27
BG108244A (bg)	2005-04-30
HUP0303735A3 (en)	2004-07-28
NO20034523D0 (no)	2003-10-09
KR20040007496A (ko)	2004-01-24
CR7069A (es)	2007-12-17
PL365026A1 (pl)	2004-12-27
CZ20032676A3 (cs)	2004-11-10
MXPA03009380A (es)	2004-04-21
IS6939A (is)	2003-09-04
PL216985B1 (pl)	2014-06-30
EA007184B1 (ru)	2006-08-25
BR0208811A (pt)	2004-03-09
BRPI0208811B8 (pt)	2021-05-25
SK12442003A3 (sk)	2004-12-01
JP2004531535A (ja)	2004-10-14
RS51166B (sr)	2010-10-31
KR100569324B1 (ko)	2006-04-07
IL157875A0 (en)	2004-03-28
CY1113515T1 (el)	2016-06-22
NZ529403A (en)	2005-06-24
IS2734B (is)	2011-04-15
PL398536A1 (pl)	2012-06-04
EP1762567B1 (en)	2012-05-02
EP1377556A1 (en)	2004-01-07
ES2283532T3 (es)	2007-11-01
EE200300497A (et)	2004-02-16
HU229025B1 (en)	2013-07-29
DK1377556T3 (da)	2007-07-16
EP1762567A1 (en)	2007-03-14
AU2002242926B2 (en)	2007-10-11
US20060020012A1 (en)	2006-01-26
DOP2002000378A (es)	2002-10-15
CZ305099B6 (cs)	2015-05-06
CY1107626T1 (el)	2013-04-18
EP1377556B1 (en)	2007-04-04
US8063044B2 (en)	2011-11-22
ATE358669T1 (de)	2007-04-15
TWI333488B (en)	2010-11-21
NO326518B1 (no)	2008-12-22
MA27009A1 (fr)	2004-12-20
ATE556059T1 (de)	2012-05-15
HRP20030783A2 (en)	2005-08-31
HRP20030783B1 (hr)	2011-11-30
US7109228B2 (en)	2006-09-19
PA8543601A1 (es)	2002-10-31
JP3806090B2 (ja)	2006-08-09
EE05400B1 (et)	2011-04-15
NO20034523L (no)	2003-12-09
EA200300943A1 (ru)	2004-08-26
BRPI0208811B1 (pt)	2018-03-13

Publication	Publication Date	Title
PL398536A1 (pl)	2012-06-04	Pochodne pirazolu i kompozycje farmaceutyczne zawierające je oraz ich zastosowanie do leczenia HIV
NO20052739L (no)	2005-08-19	CCR5-antagonister som medikamenter
CY1111693T1 (el)	2015-10-07	Αντιιικοι παραγοντες
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PT1263730E (pt)	2008-02-11	Derivados amina para o tratamento de apoptose
EA200600225A1 (ru)	2006-08-25	Производные пиперазина для лечения вич инфекций
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DE60318874D1 (en)	2008-03-13	Pyrazolderivate
MXPA02012409A (es)	2003-04-25	Derivados de pirrol para tratamiento del sida.
BR0314759A (pt)	2005-07-26	Derivados de pirazol
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GB0223234D0 (en)	2002-11-13	Chemical compounds
HUP0203161A2 (hu)	2002-12-28	Benzamidinszármazékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
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EA200500287A1 (ru)	2005-10-27	Производные 4-(3, 5-дицианофенокси)пиразола для применения в качестве модуляторов обратной транскриптазы в лечении, в числе прочего, вич-инфекции
HUP0402149A2 (hu)	2005-02-28	Vízoldható fenil-piridazin-származékok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
DK1451184T3 (da)	2008-10-27	Dimere forbindelser og deres anvendelse som antivirale midler