PL3993807T3 - SPOSÓB STABILIZOWANIA pH WODNEJ KOMPOZYCJI ZAWIERAJĄCEJ LEK - Google Patents

SPOSÓB STABILIZOWANIA pH WODNEJ KOMPOZYCJI ZAWIERAJĄCEJ LEK

Info

Publication number
PL3993807T3
PL3993807T3 PL20734428.4T PL20734428T PL3993807T3 PL 3993807 T3 PL3993807 T3 PL 3993807T3 PL 20734428 T PL20734428 T PL 20734428T PL 3993807 T3 PL3993807 T3 PL 3993807T3
Authority
PL
Poland
Prior art keywords
stabilizing
drug
aqueous composition
aqueous
composition
Prior art date
Application number
PL20734428.4T
Other languages
English (en)
Inventor
Thorsteinn Loftsson
Zoltán Fülöp
Original Assignee
Oculis Operations Sàrl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oculis Operations Sàrl filed Critical Oculis Operations Sàrl
Publication of PL3993807T3 publication Critical patent/PL3993807T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
PL20734428.4T 2019-07-01 2020-06-30 SPOSÓB STABILIZOWANIA pH WODNEJ KOMPOZYCJI ZAWIERAJĄCEJ LEK PL3993807T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19183719 2019-07-01
EP20174202 2020-05-12
PCT/EP2020/068398 WO2021001366A1 (en) 2019-07-01 2020-06-30 Method for stabilizing the ph of an aqueous composition comprising a drug

Publications (1)

Publication Number Publication Date
PL3993807T3 true PL3993807T3 (pl) 2026-05-18

Family

ID=71130991

Family Applications (1)

Application Number Title Priority Date Filing Date
PL20734428.4T PL3993807T3 (pl) 2019-07-01 2020-06-30 SPOSÓB STABILIZOWANIA pH WODNEJ KOMPOZYCJI ZAWIERAJĄCEJ LEK

Country Status (24)

Country Link
US (12) US12097209B2 (pl)
EP (2) EP3993807B1 (pl)
JP (2) JP7716996B2 (pl)
KR (1) KR20220031909A (pl)
CN (1) CN114040766A (pl)
AU (2) AU2020298754B2 (pl)
BR (1) BR112021026564A2 (pl)
CA (1) CA3142247A1 (pl)
CL (1) CL2021003532A1 (pl)
CO (1) CO2021017558A2 (pl)
DK (1) DK3993807T3 (pl)
ES (1) ES3058853T3 (pl)
FI (1) FI3993807T3 (pl)
HR (1) HRP20260033T1 (pl)
IL (1) IL289520A (pl)
LT (1) LT3993807T (pl)
MX (2) MX2021015767A (pl)
PH (1) PH12021553040A1 (pl)
PL (1) PL3993807T3 (pl)
RS (1) RS67617B1 (pl)
SI (1) SI3993807T1 (pl)
SM (1) SMT202600106T1 (pl)
WO (1) WO2021001366A1 (pl)
ZA (1) ZA202109597B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3548091T (pt) 2016-11-29 2022-01-21 Oculis SA Preparação de complexos sólidos de ciclodextrina para administração oftálmica de ingrediente farmacêutico ativo
WO2021001366A1 (en) 2019-07-01 2021-01-07 Oculis SA Method for stabilizing the ph of an aqueous composition comprising a drug
KR102589130B1 (ko) * 2021-03-24 2023-10-13 삼진제약주식회사 N-옥소 피리딘 화합물 발생을 억제하는 안질환 예방 또는 치료용 점안 조성물
US11951087B2 (en) * 2021-07-27 2024-04-09 Lanny Leo Johnson Eye wash compositions and methods
CN118647364A (zh) * 2022-02-02 2024-09-13 奥库里斯经营管理有限责任公司 多剂量眼用组合物
US20240261220A1 (en) * 2023-02-06 2024-08-08 Juewen Liu Aptamer functionalized liposomes for delivery of ocular drug for eye diseases
WO2025083031A1 (en) 2023-10-16 2025-04-24 Oculis Operations Sàrl Method of treating diabetic macular edema
WO2025082585A1 (en) 2023-10-16 2025-04-24 Oculis Operations Sàrl Method of treating diabetic macular edema
WO2026094048A1 (en) 2024-10-30 2026-05-07 Able Tx Ltd. Drug delivery to the posterior eye segment

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US172A (en) 1837-04-20 Improvement in the mode of
US8633A (en) 1852-01-06 Improvement in daguerreotype pictures
JPS60149530A (ja) 1984-01-13 1985-08-07 Takeda Chem Ind Ltd 水性製剤
JP2577049B2 (ja) 1987-06-04 1997-01-29 三共株式会社 シクロスポリン製剤
SG45449A1 (en) * 1992-05-13 1998-01-16 Sandoz Ltd Ophthalmic compositions
US5324718A (en) 1992-07-14 1994-06-28 Thorsteinn Loftsson Cyclodextrin/drug complexation
US5472954A (en) 1992-07-14 1995-12-05 Cyclops H.F. Cyclodextrin complexation
EP0709099A3 (en) 1994-09-28 1996-07-24 Senju Pharma Co Aqueous suspension for nasal administration containing cyclodextrin
TW434023B (en) 1995-09-18 2001-05-16 Novartis Ag Preserved ophthalmic composition
WO1998006381A1 (en) 1996-08-09 1998-02-19 Alcon Laboratories, Inc. Preservative systems for pharmaceutical compositions containing cyclodextrins
EP0931388B1 (en) 1996-08-29 2003-11-05 Cisco Technology, Inc. Spatio-temporal processing for communication
EP0938896A1 (en) * 1998-01-15 1999-09-01 Novartis AG Autoclavable pharmaceutical compositions containing a chelating agent
US20020198174A1 (en) 2001-05-07 2002-12-26 Allergan Sales, Inc. Disinfecting and solubilizing steroid compositions
CZ20012038A3 (cs) 1998-12-23 2001-09-12 Idea Ag Zdokonalený přípravek pro topické, neinvazivní použití in vivo
DE19957788A1 (de) 1999-12-01 2001-07-05 Schott Glas Tropfflasche
DE10036871A1 (de) 2000-07-28 2002-02-14 Pharmasol Gmbh Dispersionen zur Formulierung wenig oder schwer löslicher Wirkstoffe
EP1337237B1 (en) 2000-11-15 2009-03-11 Mohan A. Chandavarkar Pharmaceutical preparations comprising corticosteroids and antiinfective agents
EP1478404A1 (en) * 2002-02-22 2004-11-24 Pharmacia Corporation Ophthalmic antibiotic drug formulations containing a cyclodextrin compound and cetyl pyridinium chloride
WO2004069280A1 (en) 2003-02-06 2004-08-19 Cipla Ltd Pharmaceutical inclusion complexes containing a steroid and optionally an antibacterial agent
US20070148192A1 (en) 2003-02-21 2007-06-28 Laddha Ritu N Stable ophthalmic composition
ES2584183T3 (es) 2003-03-28 2016-09-26 Ares Trading S.A. Formulaciones de cladribina para suministro mejorado oral y transmucosa
EP1654002B2 (en) 2003-08-07 2014-01-29 Allergan, Inc. Compositions for delivery of therapeutics into the eyes
CN1559413A (zh) 2004-02-26 2005-01-05 胡秀爱 地塞米松磷酸钠冻干粉针及制备方法
US20050234018A1 (en) 2004-04-15 2005-10-20 Allergan, Inc. Drug delivery to the back of the eye
US6969706B1 (en) 2004-05-12 2005-11-29 Allergan, Inc. Preserved pharmaceutical compositions comprising cyclodextrins
CN100584332C (zh) 2004-12-08 2010-01-27 胡世兴 含有粉防己碱的眼用制剂及其在制备治疗眼科疾病的含有粉防己碱的眼用制剂中的应用
WO2006062875A1 (en) 2004-12-08 2006-06-15 Merck & Co., Inc. Ophthalmic nanoparticulate formulation of a cyclooxygenase-2 selective inhibitor
US20060292099A1 (en) 2005-05-25 2006-12-28 Michael Milburn Treatment of eye disorders with sirtuin modulators
US7893040B2 (en) 2005-07-22 2011-02-22 Oculis Ehf Cyclodextrin nanotechnology for ophthalmic drug delivery
WO2008057360A1 (en) 2006-11-02 2008-05-15 Riolan Technologies, Inc. Methods of treating an ocular allergy with low dose dexamethasone
JP2010531898A (ja) * 2007-06-28 2010-09-30 サイデックス・ファーマシューティカルズ・インコーポレイテッド 鼻および眼へのコルチコステロイド水溶液送達
ES2493641T3 (es) 2007-06-28 2014-09-12 Cydex Pharmaceuticals, Inc. Administración nasal de soluciones acuosas de corticosteroides
US8524267B2 (en) 2008-04-18 2013-09-03 Warsaw Orthopedic, Inc. Dexamethasone formulations in a biodegradable material
US10463677B2 (en) 2008-11-07 2019-11-05 Cydex Pharmaceuticals, Inc. Composition containing sulfoalkyl ether cyclodextrin and latanoprost
US20110212142A1 (en) * 2008-11-17 2011-09-01 Laila Pharmaceuticals Pvt.Ltd. Curcuminoids and its metabolites for the application in ocular diseases
CN101926760A (zh) 2009-06-24 2010-12-29 天津金耀集团有限公司 2-羟丙基-β-环糊精包合地塞米松注射液
US8708781B2 (en) 2010-12-05 2014-04-29 Ethicon, Inc. Systems and methods for grinding refractory metals and refractory metal alloys
US9034931B2 (en) 2010-12-28 2015-05-19 Rohto Pharmaceutical Co., Ltd. Aqueous ophthalmic composition
US20140163080A1 (en) 2011-02-03 2014-06-12 Gnt, Llc Compositions and Methods for Treatment of Glaucoma
AU2013259573B2 (en) 2012-05-08 2018-02-15 Onyx Therapeutics, Inc. Cyclodextrin complexation Methods for Formulating Peptide Proteasome Inhibitors
KR101370411B1 (ko) 2012-08-24 2014-03-06 린나이코리아 주식회사 스팀 컨벡션 오븐
PL2887923T3 (pl) 2012-08-24 2023-08-14 Sun Pharmaceutical Industries Limited Preparat okulistyczny polioksylipidu lub polioksylowego kwasu tłuszczowego i leczenie chorób oczu
KR101475776B1 (ko) 2012-08-24 2014-12-24 영진약품공업 주식회사 이중 포화 인지질을 포함하는 안정한 피부 외용 조성물
DK3043777T3 (da) * 2013-09-10 2020-07-20 Fresh Cut Dev Llc Sublingual buprenorphinspray
BR112017002356A2 (pt) * 2014-08-08 2017-11-28 Shanghai Hightide Biopharmaceutical Ltd composições de formulação líquida, dispositivos de entrega de medicamento e métodos para preparação e uso dos mesmos
AU2016272700A1 (en) * 2015-05-29 2017-12-14 Oculis ehf. Formation of cyclosporin A/cyclodextrin nanoparticles
US11052094B2 (en) 2015-05-29 2021-07-06 Sydnexis, Inc. D2O stabilized pharmaceutical formulations
WO2017007957A1 (en) * 2015-07-07 2017-01-12 Mast Therapeutics, Inc. Reduced sodium poloxamer-188 formulations and methods for use
AR106691A1 (es) 2015-11-13 2018-02-07 Ohr Pharmaceutical Inc Formulaciones oftálmicas de escualamina
CN109152774A (zh) 2016-05-09 2019-01-04 奥尔德拉医疗公司 眼部炎性病症和疾病的组合治疗
PT3548091T (pt) 2016-11-29 2022-01-21 Oculis SA Preparação de complexos sólidos de ciclodextrina para administração oftálmica de ingrediente farmacêutico ativo
WO2019043169A1 (en) 2017-09-01 2019-03-07 Murray & Poole Enterprises, Ltd METHODS AND COMPOSITIONS FOR THE TREATMENT OF OPHTHALMIC CONDITIONS
US20190105264A1 (en) 2017-10-06 2019-04-11 Aciont Inc. Non-invasive ocular drug delivery devices
JP7324210B2 (ja) 2018-01-31 2023-08-09 ティダブリューアイ・バイオテクノロジー・インコーポレイテッド トファシチニブを含む局所製剤
JP2022516099A (ja) 2018-12-27 2022-02-24 サーフィス オフサルミクス,インコーポレイテッド 眼科用医薬組成物及び癌表面疾患の処置方法
WO2021001366A1 (en) 2019-07-01 2021-01-07 Oculis SA Method for stabilizing the ph of an aqueous composition comprising a drug
EA202290086A1 (ru) 2020-05-12 2022-03-18 Окюлис Са СПОСОБ СТАБИЛИЗАЦИИ рН ВОДНОЙ КОМПОЗИЦИИ, СОДЕРЖАЩЕЙ ЛЕКАРСТВЕННОЕ СРЕДСТВО
CN118647364A (zh) 2022-02-02 2024-09-13 奥库里斯经营管理有限责任公司 多剂量眼用组合物
CN115837027A (zh) 2022-11-15 2023-03-24 中国药科大学 一种眼用地塞米松药物组合物
WO2025083031A1 (en) 2023-10-16 2025-04-24 Oculis Operations Sàrl Method of treating diabetic macular edema

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Publication number Publication date
AU2020298754B2 (en) 2025-06-26
US20240058360A1 (en) 2024-02-22
US20250009758A1 (en) 2025-01-09
US20240058361A1 (en) 2024-02-22
EP4670738A3 (en) 2026-03-04
EP3993807B1 (en) 2025-12-17
US20240058359A1 (en) 2024-02-22
JP2022538659A (ja) 2022-09-05
US12403148B2 (en) 2025-09-02
IL289520A (en) 2022-03-01
EP4670738A2 (en) 2025-12-31
US20250387411A1 (en) 2025-12-25
JP7716996B2 (ja) 2025-08-01
US20240058362A1 (en) 2024-02-22
SMT202600106T1 (it) 2026-05-12
CL2021003532A1 (es) 2022-08-19
WO2021001366A1 (en) 2021-01-07
US20250009759A1 (en) 2025-01-09
EP3993807A1 (en) 2022-05-11
US12090160B2 (en) 2024-09-17
US12397001B2 (en) 2025-08-26
AU2020298754A1 (en) 2021-12-23
CO2021017558A2 (es) 2022-01-17
US12397000B2 (en) 2025-08-26
US12097209B2 (en) 2024-09-24
US12403147B2 (en) 2025-09-02
RS67617B1 (sr) 2026-02-27
FI3993807T3 (fi) 2026-01-28
US20250009760A1 (en) 2025-01-09
LT3993807T (lt) 2026-02-25
US12090162B2 (en) 2024-09-17
US20250009761A1 (en) 2025-01-09
MX2026000961A (es) 2026-03-02
JP2025098194A (ja) 2025-07-01
SI3993807T1 (sl) 2026-04-30
TW202114697A (zh) 2021-04-16
US20250009757A1 (en) 2025-01-09
US20250009762A1 (en) 2025-01-09
US12383565B2 (en) 2025-08-12
ES3058853T3 (en) 2026-03-13
HRP20260033T1 (hr) 2026-03-27
CA3142247A1 (en) 2021-01-07
KR20220031909A (ko) 2022-03-14
MX2021015767A (es) 2022-01-27
DK3993807T3 (da) 2026-01-19
CN114040766A (zh) 2022-02-11
PH12021553040A1 (en) 2022-07-25
AU2025220806A1 (en) 2025-09-11
US20220354869A1 (en) 2022-11-10
BR112021026564A2 (pt) 2022-02-15
US12090161B2 (en) 2024-09-17
US12397002B2 (en) 2025-08-26
ZA202109597B (en) 2023-10-25