PL400248A1 - Nowy sposób syntezy polifosforanów (2) - Google Patents

Nowy sposób syntezy polifosforanów (2)

Info

Publication number
PL400248A1
PL400248A1 PL400248A PL40024812A PL400248A1 PL 400248 A1 PL400248 A1 PL 400248A1 PL 400248 A PL400248 A PL 400248A PL 40024812 A PL40024812 A PL 40024812A PL 400248 A1 PL400248 A1 PL 400248A1
Authority
PL
Poland
Prior art keywords
reaction
general formula
oxazaphospholidine
polyphosphates
compound
Prior art date
Application number
PL400248A
Other languages
English (en)
Other versions
PL231078B1 (pl
Inventor
Marcin Krzysztof Chmielewski
Joanna Romanowska
Original Assignee
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instytut Chemii Bioorganicznej Polskiej Akademii Nauk filed Critical Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Priority to PL400248A priority Critical patent/PL231078B1/pl
Priority to PCT/PL2013/000098 priority patent/WO2014025272A1/en
Priority to US14/412,951 priority patent/US9376460B2/en
Priority to EP13750163.1A priority patent/EP2880044B1/en
Publication of PL400248A1 publication Critical patent/PL400248A1/pl
Publication of PL231078B1 publication Critical patent/PL231078B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65844—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a five-membered ring which may be condensed with another ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C07H1/04—Introducing polyphosphoric acid radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)

Abstract

Przedmiotem wynalazku są nowe sposoby syntezy analogów polifosforanowych, związków o znaczeniu biologicznym takich jak nukleozydy, oligonukleotydy, cukry, peptydy, białka oraz mających zastosowanie w chemii organicznej, biologii molekularnej i biotechnologii. W odmianie sposób syntezy polifosforanów organicznych o ogólnym wzorze 1, w którym n przyjmuje wartość od 0 do 2 zaś X oznacza resztę cząsteczki organicznej w szczególności nukleozydu, oligonukleotydu, węglowodanu peptydu lub reszty białkowej polega na reakcji pomiędzy związkiem o wzorze ogólnym 2, w którym X ma wyżej podane znaczenie, a odpowiednią podstawioną pochodną 2-pirydylo-[1,3,2]oksazafosfolidyny lub odpowiednią podstawioną pochodną 2-pirymidylo-[1,3,2]oksazafosfolidyny, a następnie produkt tej reakcji poddaje się reakcji z solą amoniową kwasu polifosforanowego. Po zakończeniu reakcji produkt poddaje się utlenianiu jodem, po czym znanymi sposobami izoluje się związek o wzorze ogólnym 1.
PL400248A 2012-08-05 2012-08-05 Sposób syntezy polifosforanów PL231078B1 (pl)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PL400248A PL231078B1 (pl) 2012-08-05 2012-08-05 Sposób syntezy polifosforanów
PCT/PL2013/000098 WO2014025272A1 (en) 2012-08-05 2013-07-29 New method of polyphosphate synthesis
US14/412,951 US9376460B2 (en) 2012-08-05 2013-07-29 Method of polyphosphate synthesis
EP13750163.1A EP2880044B1 (en) 2012-08-05 2013-07-29 New method of polyphosphate synthesis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL400248A PL231078B1 (pl) 2012-08-05 2012-08-05 Sposób syntezy polifosforanów

Publications (2)

Publication Number Publication Date
PL400248A1 true PL400248A1 (pl) 2014-02-17
PL231078B1 PL231078B1 (pl) 2019-01-31

Family

ID=48986196

Family Applications (1)

Application Number Title Priority Date Filing Date
PL400248A PL231078B1 (pl) 2012-08-05 2012-08-05 Sposób syntezy polifosforanów

Country Status (4)

Country Link
US (1) US9376460B2 (pl)
EP (1) EP2880044B1 (pl)
PL (1) PL231078B1 (pl)
WO (1) WO2014025272A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3455232B1 (en) * 2016-05-12 2020-05-06 Roche Innovation Center Copenhagen A/S Enhanced coupling of stereodefined oxazaphospholidine phosphoramidite monomers to nucleoside or oligonucleotide
CN109680342B (zh) * 2018-12-18 2021-09-28 上海药明康德新药开发有限公司 DNA编码化合物库中On-DNA芳硝基化合物还原成On-DNA芳胺化合物的方法
CN113354545B (zh) * 2020-03-06 2023-06-23 深圳华大生命科学研究院 一种焦磷酸盐及其制备方法

Also Published As

Publication number Publication date
US20150203524A1 (en) 2015-07-23
PL231078B1 (pl) 2019-01-31
EP2880044A1 (en) 2015-06-10
US9376460B2 (en) 2016-06-28
EP2880044B1 (en) 2019-11-27
WO2014025272A1 (en) 2014-02-13

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