PL400941A1 - Process for preparing 3?-Hydroxy-17a-oxa-D-homo-5?-Androstan-17-one - Google Patents

Process for preparing 3?-Hydroxy-17a-oxa-D-homo-5?-Androstan-17-one

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Publication number
PL400941A1
PL400941A1 PL400941A PL40094112A PL400941A1 PL 400941 A1 PL400941 A1 PL 400941A1 PL 400941 A PL400941 A PL 400941A PL 40094112 A PL40094112 A PL 40094112A PL 400941 A1 PL400941 A1 PL 400941A1
Authority
PL
Poland
Prior art keywords
hydroxy
androstan
oxa
homo
preparing
Prior art date
Application number
PL400941A
Other languages
Polish (pl)
Other versions
PL219262B1 (en
Inventor
Alina Swizdor
Teresa Kołek
Anna Panek
Natalia Milecka
Original Assignee
Uniwersytet Przyrodniczy We Wroclawiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy We Wroclawiu filed Critical Uniwersytet Przyrodniczy We Wroclawiu
Priority to PL400941A priority Critical patent/PL219262B1/en
Publication of PL400941A1 publication Critical patent/PL400941A1/en
Publication of PL219262B1 publication Critical patent/PL219262B1/en

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

Wynalazek polega na wytwarzaniu 3?-hydroksy-17a-oksa-D-homo-5?-androstan-17-onu o wzorze 2, w wyniku mikrobiologicznego utleniania typu Baeyera-Villigera, z wykorzystaniem systemu enzymatycznego szczepu Penicillium lanoso-coeruleum, w którym jako substrat stosuje sie 3?-hydroksy-5?-androstan-17-on, o wzorze 1. Sposobem, wedlug wynalazku, mozna otrzymac steroidowy lakton - analog strukturalny antynowotworowego i antyandrogennego testolaktonu, o potencjalnie podobnej aktywnosci biologicznej.The invention consists in the production of 3'-hydroxy-17a-oxa-D-homo-5'-androstan-17-one of the formula 2, as a result of microbial oxidation of the Baeyer-Villiger type, using the enzyme system of the Penicillium lanoso-coeruleum strain, in which 3'-hydroxy-5'-androstane-17-one of the formula 1 is used as a substrate. By the method according to the invention, it is possible to obtain a steroidal lactone - a structural analogue of the anticancer and antiandrogenic testolactone, with potentially similar biological activity.

PL400941A 2012-09-27 2012-09-27 Process for preparing 3?-Hydroxy-17a-oxa-D-homo-5?-Androstan-17-one PL219262B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL400941A PL219262B1 (en) 2012-09-27 2012-09-27 Process for preparing 3?-Hydroxy-17a-oxa-D-homo-5?-Androstan-17-one

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL400941A PL219262B1 (en) 2012-09-27 2012-09-27 Process for preparing 3?-Hydroxy-17a-oxa-D-homo-5?-Androstan-17-one

Publications (2)

Publication Number Publication Date
PL400941A1 true PL400941A1 (en) 2013-05-27
PL219262B1 PL219262B1 (en) 2015-04-30

Family

ID=48522800

Family Applications (1)

Application Number Title Priority Date Filing Date
PL400941A PL219262B1 (en) 2012-09-27 2012-09-27 Process for preparing 3?-Hydroxy-17a-oxa-D-homo-5?-Androstan-17-one

Country Status (1)

Country Link
PL (1) PL219262B1 (en)

Also Published As

Publication number Publication date
PL219262B1 (en) 2015-04-30

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Effective date: 20141020