PL4055055T3 - Przeciwciała dwuswoiste przeciwko ceacam5 i cd47 - Google Patents

Przeciwciała dwuswoiste przeciwko ceacam5 i cd47

Info

Publication number
PL4055055T3
PL4055055T3 PL21834934.8T PL21834934T PL4055055T3 PL 4055055 T3 PL4055055 T3 PL 4055055T3 PL 21834934 T PL21834934 T PL 21834934T PL 4055055 T3 PL4055055 T3 PL 4055055T3
Authority
PL
Poland
Prior art keywords
antibodies against
bispecific antibodies
against ceacam5
ceacam5
bispecific
Prior art date
Application number
PL21834934.8T
Other languages
English (en)
Inventor
Vanessa BUATOIS
Anja SECKINGER
Dirk HOSE
Original Assignee
Lamkap Bio Beta Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lamkap Bio Beta Ag filed Critical Lamkap Bio Beta Ag
Publication of PL4055055T3 publication Critical patent/PL4055055T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007Carcino-embryonic Antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pens And Brushes (AREA)
  • Conversion Of X-Rays Into Visible Images (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL21834934.8T 2020-12-18 2021-12-17 Przeciwciała dwuswoiste przeciwko ceacam5 i cd47 PL4055055T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20215766 2020-12-18
US202163135996P 2021-01-11 2021-01-11
PCT/IB2021/061983 WO2022130348A1 (en) 2020-12-18 2021-12-17 Bispecific antibodies against ceacam5 and cd47

Publications (1)

Publication Number Publication Date
PL4055055T3 true PL4055055T3 (pl) 2024-04-15

Family

ID=79164846

Family Applications (1)

Application Number Title Priority Date Filing Date
PL21834934.8T PL4055055T3 (pl) 2020-12-18 2021-12-17 Przeciwciała dwuswoiste przeciwko ceacam5 i cd47

Country Status (17)

Country Link
US (2) US11753481B2 (pl)
EP (1) EP4055055B1 (pl)
JP (1) JP2024501809A (pl)
KR (1) KR20230121772A (pl)
AU (1) AU2021400227A1 (pl)
CA (1) CA3193210A1 (pl)
CL (1) CL2023001797A1 (pl)
CO (1) CO2023009100A2 (pl)
ES (1) ES2967381T3 (pl)
HR (1) HRP20240213T1 (pl)
HU (1) HUE065728T2 (pl)
IL (1) IL301701A (pl)
MX (1) MX2023007220A (pl)
PE (1) PE20231386A1 (pl)
PL (1) PL4055055T3 (pl)
RS (1) RS65211B1 (pl)
WO (1) WO2022130348A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210221908A1 (en) * 2018-06-03 2021-07-22 Lamkap Bio Beta Ltd. Bispecific antibodies against ceacam5 and cd47
PL4055055T3 (pl) 2020-12-18 2024-04-15 Lamkap Bio Beta Ag Przeciwciała dwuswoiste przeciwko ceacam5 i cd47
IL314916A (en) * 2022-03-07 2024-10-01 Novimmune Sa Bispecific CD28 antibodies for targeted T cell activation
JP2025509702A (ja) 2022-03-14 2025-04-11 ラムキャップ バイオ ガンマ エージー GPC3陽性悪性細胞を標的殺傷するための二重特異性GPC3xCD28抗体およびGPC3xCD3抗体ならびにそれらの組み合わせ
US20250230256A1 (en) 2022-06-16 2025-07-17 Lamkap Bio Beta Ltd Combination therapy of bispecific antibodies against ceacam5 and cd47 and bispecific antibodies against ceacam5 and cd3
WO2025100827A1 (ko) * 2023-11-09 2025-05-15 주식회사 다안바이오테라퓨틱스 항 ceacam5 항체 및 이의 용도

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294372B1 (en) 1997-03-14 2001-09-25 University Of Victoria Innovation & Dev. Corp. Replication genes and gene products from small cryptic plasmids and methods for constructing controlled-replication plasmid vectors
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
IL149820A0 (en) 2002-05-23 2002-11-10 Curetech Ltd Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
US7232888B2 (en) 2002-07-01 2007-06-19 Massachusetts Institute Of Technology Antibodies against tumor surface antigens
JP4511943B2 (ja) 2002-12-23 2010-07-28 ワイス エルエルシー Pd−1に対する抗体およびその使用
EP2368578A1 (en) 2003-01-09 2011-09-28 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
WO2005018669A1 (en) 2003-08-18 2005-03-03 Macrogenics, Inc. Fcϝriib-specific antibodies and methods of use thereof
NZ545776A (en) 2003-08-22 2009-05-31 Biogen Idec Inc Improved antibodies having altered effector function and methods for making the same
WO2005063815A2 (en) 2003-11-12 2005-07-14 Biogen Idec Ma Inc. Fcϝ receptor-binding polypeptide variants and methods related thereto
CA2548817A1 (en) 2003-12-04 2005-06-23 Xencor, Inc. Methods of generating variant proteins with increased host string content and compositions thereof
EP1737890A2 (en) 2004-03-24 2007-01-03 Xencor, Inc. Immunoglobulin variants outside the fc region
MXPA06012601A (es) 2004-05-10 2007-05-10 Macrogenics Inc Anticuerpos especificos de fcy riib humanizados y metodos de uso de los mismos.
WO2006085967A2 (en) 2004-07-09 2006-08-17 Xencor, Inc. OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
AU2005272993B2 (en) 2004-07-15 2010-02-11 Xencor, Inc. Optimized Fc variants
EP1778726A4 (en) 2004-08-16 2009-03-18 Medimmune Inc INTEGRIN ANTAGONISTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-ASSAYED CYTOTOXICITY ACTIVITY
WO2006047350A2 (en) 2004-10-21 2006-05-04 Xencor, Inc. IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
US7632497B2 (en) 2004-11-10 2009-12-15 Macrogenics, Inc. Engineering Fc Antibody regions to confer effector function
CA2602663A1 (en) 2005-03-31 2006-10-05 Xencor, Inc. Fc variants with optimized properties
WO2006116260A2 (en) 2005-04-26 2006-11-02 Medimmune, Inc. Modulation of antibody effector function by hinge domain engineering
CN103059138B (zh) 2005-05-09 2015-10-28 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
WO2007005874A2 (en) 2005-07-01 2007-01-11 Medarex, Inc. Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
US7557190B2 (en) 2005-07-08 2009-07-07 Xencor, Inc. Optimized proteins that target Ep-CAM
SI2573114T1 (sl) 2005-08-10 2016-08-31 Macrogenics, Inc. Identifikacija in inženiring protiteles z variantnimi fc regijami in postopki za njih uporabo
CA2624189A1 (en) 2005-10-03 2007-04-12 Xencor, Inc. Fc variants with optimized fc receptor binding properties
AU2006302254B2 (en) 2005-10-06 2011-05-26 Xencor, Inc. Optimized anti-CD30 antibodies
EP2388273B1 (en) 2005-10-21 2017-07-05 LFB USA, Inc. Antibodies with enhanced antibody-dependent cellular cytoxicity activity, methods of their production and use
RS55181B1 (sr) 2005-12-21 2017-01-31 Amgen Res Munich Gmbh Farmaceutske kompozicije sa rezistencijom na rastvorljivi cea
AU2007226752A1 (en) 2006-03-10 2007-09-20 Macrogenics, Inc. Identification and engineering of antibodies with variant heavy chains and methods of using same
IL177158A0 (en) 2006-07-30 2008-01-20 Assaf Klar Method for designing and implementing improved longitudinal flexibility multilayered pipeline
SI2383297T1 (sl) 2006-08-14 2013-06-28 Xencor Inc. Optimizirana antitelesa, ki ciljajo cd19
WO2008036688A2 (en) 2006-09-18 2008-03-27 Xencor, Inc. Optimized antibodies that target hm1.24
WO2008121160A2 (en) 2006-11-21 2008-10-09 Xencor, Inc. Optimized antibodies that target cd5
WO2008140603A2 (en) 2006-12-08 2008-11-20 Macrogenics, Inc. METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING
WO2008091798A2 (en) 2007-01-22 2008-07-31 Xencor, Inc. Optimized ca9 antibodies and methods of using the same
WO2008091954A2 (en) 2007-01-23 2008-07-31 Xencor, Inc. Optimized cd40 antibodies and methods of using the same
WO2008092117A2 (en) 2007-01-25 2008-07-31 Xencor, Inc. Immunoglobulins with modifications in the fcr binding region
WO2008098115A2 (en) 2007-02-07 2008-08-14 Xencor, Inc. Optimized igf-1r antibodies and methods of using the same
LT2176298T (lt) 2007-05-30 2018-04-10 Xencor, Inc. Būdai ir kompozicijos, skirti cd32b ekspresuojančių ląstelių slopinimui
EP3222634A1 (en) 2007-06-18 2017-09-27 Merck Sharp & Dohme B.V. Antibodies to human programmed death receptor pd-1
PT2242773T (pt) 2008-02-11 2017-09-15 Cure Tech Ltd Anticorpos monoclonais para o tratamento de tumores
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
CA2723197C (en) 2008-05-02 2017-09-19 Seattle Genetics, Inc. Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
PL2350129T3 (pl) 2008-08-25 2015-12-31 Amplimmune Inc Kompozycje antagonistów PD-1 i sposoby stosowania
BRPI0917891A2 (pt) 2008-08-25 2015-11-24 Amplimmune Inc antagonistas de pd-1 e métodos de utilização dos mesmos
EP3190128B1 (en) 2008-09-17 2018-11-14 Xencor, Inc. Compositions and methods for treating ige-mediated disorders
NZ717213A (en) 2008-12-09 2017-10-27 Genentech Inc Anti-pd-l1 antibodies and their use to enhance t-cell function
WO2011034660A1 (en) 2009-09-16 2011-03-24 Immunomedics, Inc. Class i anti-cea antibodies and uses thereof
AU2010297580B2 (en) 2009-09-22 2014-07-31 Probiogen Ag Process for producing molecules containing specialized glycan structures
US9834615B2 (en) 2010-08-16 2017-12-05 Novimmune Sa Methods for the generation of multispecific and multivalent antibodies
EP2681244B1 (en) 2011-03-02 2017-11-29 Roche Glycart AG Cea antibodies
US20140242081A1 (en) 2011-07-18 2014-08-28 Micromet Ag Dosing regimens for treatment of cea-expressing cancers
WO2013019906A1 (en) 2011-08-01 2013-02-07 Genentech, Inc. Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors
CA2853011C (en) 2011-10-19 2022-09-06 Novimmune S.A. Methods of purifying antibodies
US20140140989A1 (en) 2012-02-06 2014-05-22 Inhibrx Llc Non-Platelet Depleting and Non-Red Blood Cell Depleting CD47 Antibodies and Methods of Use Thereof
HK1203971A1 (en) 2012-05-15 2015-11-06 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
EP2925782B1 (en) 2012-12-03 2020-01-22 NovImmune SA Anti-cd47 antibodies and methods of use thereof
EP2945969A1 (en) 2013-01-15 2015-11-25 Xencor, Inc. Rapid clearance of antigen complexes using novel antibodies
DK2961771T3 (da) 2013-02-26 2020-03-02 Roche Glycart Ag Bispecifikke, T-celle-aktiverende, antigenbindende molekyler, der er specifikke for CD3 og CEA
CN104936985A (zh) 2013-02-26 2015-09-23 罗切格利卡特公司 双特异性t细胞活化性抗原结合分子
WO2015026634A1 (en) 2013-08-20 2015-02-26 Merck Sharp & Dohme Corp. Treating cancer with a combination of a pd-1 antagonist and dinaciclib
EP3096782A4 (en) 2014-01-21 2017-07-26 Medlmmune, LLC Compositions and methods for modulating and redirecting immune responses
ES2916923T3 (es) 2014-07-11 2022-07-06 Ventana Med Syst Inc Anticuerpos anti-PD-L1 y usos diagnósticos de los mismos
EP3277821B1 (en) 2015-03-31 2019-07-24 NovImmune SA Method for optimizing the assembly and production of hetero-multimeric protein complexes
BR112018000835A2 (pt) 2015-10-02 2018-09-11 Hoffmann La Roche molécula, um ou mais polinucleotídeos, um ou mais vetores, célula, método de produção da molécula, composição, uso da molécula, método de tratamento de uma doença e método para induzir a lise de uma célula-alvo
GB2546072B (en) 2016-01-05 2019-07-10 Bja Trading Ltd Attachment assembly and method of using same
AU2017205089B2 (en) 2016-01-08 2023-10-05 F. Hoffmann-La Roche Ag Methods of treating CEA-positive cancers using PD-1 axis binding antagonists and anti-CEA/anti-CD3 bispecific antibodies
TW201741340A (zh) 2016-05-09 2017-12-01 賽基公司 Cd47抗體及使用其之方法
WO2018057955A1 (en) 2016-09-23 2018-03-29 Elstar Therapeutics, Inc. Multispecific antibody molecules comprising lambda and kappa light chains
WO2018098384A1 (en) 2016-11-22 2018-05-31 Regents Of The University Of California Segregation modulation for immunotherapy
EP3623388A4 (en) 2017-05-08 2021-08-04 Shanghai JMT-Bio Technology Co., Ltd. BISPECIFIC RECOMBINANT PROTEIN AND ITS USE
CA3070519A1 (en) 2017-07-21 2019-01-24 Novimmune Sa Generating multispecific antibody mixtures and methods of uses thereof
US20210221908A1 (en) * 2018-06-03 2021-07-22 Lamkap Bio Beta Ltd. Bispecific antibodies against ceacam5 and cd47
EP3831849A1 (en) 2019-12-02 2021-06-09 LamKap Bio beta AG Bispecific antibodies against ceacam5 and cd47
PL4055055T3 (pl) 2020-12-18 2024-04-15 Lamkap Bio Beta Ag Przeciwciała dwuswoiste przeciwko ceacam5 i cd47

Also Published As

Publication number Publication date
CA3193210A1 (en) 2022-06-23
AU2021400227A9 (en) 2024-05-30
PE20231386A1 (es) 2023-09-12
CL2023001797A1 (es) 2024-02-09
IL301701A (en) 2023-05-01
JP2024501809A (ja) 2024-01-16
EP4055055B1 (en) 2023-11-22
US11753481B2 (en) 2023-09-12
RS65211B1 (sr) 2024-03-29
CO2023009100A2 (es) 2023-08-18
AU2021400227A1 (en) 2023-04-27
US20240101705A1 (en) 2024-03-28
MX2023007220A (es) 2023-08-25
HUE065728T2 (hu) 2024-06-28
ES2967381T3 (es) 2024-04-30
HRP20240213T1 (hr) 2024-04-26
KR20230121772A (ko) 2023-08-21
EP4055055A1 (en) 2022-09-14
EP4055055C0 (en) 2023-11-22
WO2022130348A1 (en) 2022-06-23
US20220195067A1 (en) 2022-06-23

Similar Documents

Publication Publication Date Title
PL4055055T3 (pl) Przeciwciała dwuswoiste przeciwko ceacam5 i cd47
IL291482A (en) Bispecific antibodies against ceacam5 and cd3
EP3802599C0 (en) BISPECIFIC ANTIBODIES AGAINST CEACAM5 AND CD47
EP4010378A4 (en) ANTICCR8 MONOCLONAL ANTIBODIES AND USES THEREOF
SI3872091T1 (sl) Protitelesa proti SARS-COV-2
ZA202208807B (en) Anti-tigit antibodies and usage method
DK3823664T3 (da) Bispecifikke anti BCMA-X-anti CD3-antistoffer og anvendelser deraf
IL274519A (en) CD47 antibodies and their uses for cancer treatment
ZA202105150B (en) Conjugate comprising ligand and ceacam5 antibody fab fragment
LT4274851T (lt) Anti-gprc5d monokloniniai antikūnai ir jų panaudojimas
IL307519A (en) Antibodies against ILT4, anti-ILT4\PD-L1 bispecific antibody and their uses
IL310662A (en) Anti-CD161 antibodies and their uses
EP3988574A4 (en) AGAINST HER2 BI-SPECIFIC ANTIBODIES AND THEIR USE
IL291082A (en) Anti-vsig4 antibody or antigen-binding fragment and uses thereof
EP4382541A4 (en) BISPECIFIC ANTIBODY AND USE THEREOF
ES3059248T3 (en) Humanized anti-il17a antibody and use thereof
IL291049A (en) Anti-cd47 monoclonal antibody and use thereof
EP4004054A4 (en) ANTI-HER2/ANTI-4-1BB BISPECIFIC ANTIBODIES AND ITS APPLICATION
IL315888A (en) Transgenic CD200R antibodies and their uses
AU2017255888A1 (en) Humanized anti-BASIGIN antibodies and the use thereof
IL314678A (en) Bispecific antibodies against cd277 and a tumor-antigen
IL285569A (en) Anti-pd-l1 antibody and use thereof
EP4303231A4 (en) BISPECIFIC ANTIBODY
IL272733A (en) Monoclonal antibodies against pathological alpha-synuclein, and methods using same
EP4159764A4 (en) BISPECIFIC ANTI-PDL1 × EGFR ANTIBODY