PL406524A1 - Sposób otrzymywania wardenafilu i jego soli - Google Patents

Sposób otrzymywania wardenafilu i jego soli

Info

Publication number
PL406524A1
PL406524A1 PL406524A PL40652413A PL406524A1 PL 406524 A1 PL406524 A1 PL 406524A1 PL 406524 A PL406524 A PL 406524A PL 40652413 A PL40652413 A PL 40652413A PL 406524 A1 PL406524 A1 PL 406524A1
Authority
PL
Poland
Prior art keywords
vardenafil
monohydrochloride
obtaining
base
triazine
Prior art date
Application number
PL406524A
Other languages
English (en)
Other versions
PL223869B1 (pl
Inventor
Roman Szramka
Jerzy Drygas
Marcin Szulc
Robert Rynkiewicz
Original Assignee
Starogardzkie Zakłady Farmaceutyczne Polpharma Spółka Akcyjna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Starogardzkie Zakłady Farmaceutyczne Polpharma Spółka Akcyjna filed Critical Starogardzkie Zakłady Farmaceutyczne Polpharma Spółka Akcyjna
Priority to PL406524A priority Critical patent/PL223869B1/pl
Priority to EA201600466A priority patent/EA032040B1/ru
Priority to PCT/PL2014/000135 priority patent/WO2015093994A1/en
Priority to ES14827879T priority patent/ES2866627T3/es
Priority to US15/104,285 priority patent/US9845328B2/en
Priority to HRP20210594TT priority patent/HRP20210594T1/hr
Priority to HUE14827879A priority patent/HUE055214T2/hu
Priority to EP14827879.9A priority patent/EP3083629B1/en
Publication of PL406524A1 publication Critical patent/PL406524A1/pl
Publication of PL223869B1 publication Critical patent/PL223869B1/pl
Priority to CY20211100531T priority patent/CY1124259T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)

Abstract

Ujawniono sposób otrzymywania zasady wardenafilu, w bezwodnych warunkach, przez chlorosulfonowanie 2-(2-etoksy-fenylo)-5-metylo-7-propylo-3H-imidazo[5,1-f][1,2,4]triazyn-4-onu w mieszaninie chlorku tionylu i kwasu chlorosulfonowego, a następnie amidowanie powstałego chlorku kwasu 4-etoksy-3-(5-metylo-4-okso-7-propylo-3,4-dihydroimidazo[5,1-f][1,2,4]-triazyn-2-ylo)benzeno-sulfonowego N-etylopiperazyną, w rozpuszczalniku aprotycznym, w obecności nieorganicznej zasady oraz sposób przeprowadzania otrzymanej zasady wardenafilu w trójwodzian monochlorowodorku wardenafilu o temperaturze topnienia 234°C przez kontaktowanie z wodą bezwodnej modyfikacji V monochlorowodorku wardenafilu w rozpuszczalniku organicznym. Przedmiotem wynalazku jest również bezwodna modyfikacja V monochlorowodorku wardenafilu oraz jej zastosowanie do otrzymywania trójwodzianu monochlorowodorku wardenafilu o temperaturze topnienia 234°C.
PL406524A 2013-12-16 2013-12-16 Sposób otrzymywania wardenafilu i jego soli PL223869B1 (pl)

Priority Applications (9)

Application Number Priority Date Filing Date Title
PL406524A PL223869B1 (pl) 2013-12-16 2013-12-16 Sposób otrzymywania wardenafilu i jego soli
EA201600466A EA032040B1 (ru) 2013-12-16 2014-12-08 Способ получения варденафила и его солей
PCT/PL2014/000135 WO2015093994A1 (en) 2013-12-16 2014-12-08 The method for manufacturing of vardenafil and its salts
ES14827879T ES2866627T3 (es) 2013-12-16 2014-12-08 Método para fabricar vardenafilo y sus sales
US15/104,285 US9845328B2 (en) 2013-12-16 2014-12-08 Method for manufacturing of vardenafil and its salts
HRP20210594TT HRP20210594T1 (hr) 2013-12-16 2014-12-08 Postupak za proizvodnju vardenafila i njegovih soli
HUE14827879A HUE055214T2 (hu) 2013-12-16 2014-12-08 Eljárás vardenafilnak és sóinak elkészítésére
EP14827879.9A EP3083629B1 (en) 2013-12-16 2014-12-08 The method for manufacturing of vardenafil and its salts
CY20211100531T CY1124259T1 (el) 2013-12-16 2021-06-14 Μεθοδος για παρασκευη βαρδεναφιλης και αλατων αυτης

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL406524A PL223869B1 (pl) 2013-12-16 2013-12-16 Sposób otrzymywania wardenafilu i jego soli

Publications (2)

Publication Number Publication Date
PL406524A1 true PL406524A1 (pl) 2015-06-22
PL223869B1 PL223869B1 (pl) 2016-11-30

Family

ID=52355157

Family Applications (1)

Application Number Title Priority Date Filing Date
PL406524A PL223869B1 (pl) 2013-12-16 2013-12-16 Sposób otrzymywania wardenafilu i jego soli

Country Status (9)

Country Link
US (1) US9845328B2 (pl)
EP (1) EP3083629B1 (pl)
CY (1) CY1124259T1 (pl)
EA (1) EA032040B1 (pl)
ES (1) ES2866627T3 (pl)
HR (1) HRP20210594T1 (pl)
HU (1) HUE055214T2 (pl)
PL (1) PL223869B1 (pl)
WO (1) WO2015093994A1 (pl)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2395558C (en) 1997-11-12 2007-07-17 Bayer Aktiengesellschaft Intermediates for 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
DE10063108A1 (de) 2000-12-18 2002-06-20 Bayer Ag Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
CN100360531C (zh) 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
US7977478B2 (en) * 2006-03-13 2011-07-12 Dr. Reddy's Laboratories Limited Polymorphic forms of vardenafil
CZ2011767A3 (cs) 2011-11-24 2013-06-05 Zentiva, K.S. Zpusob prípravy a izolace solí vardenafilu s kyselinami

Also Published As

Publication number Publication date
EP3083629A1 (en) 2016-10-26
WO2015093994A1 (en) 2015-06-25
EA201600466A1 (ru) 2017-03-31
CY1124259T1 (el) 2022-07-22
HUE055214T2 (hu) 2021-11-29
HRP20210594T1 (hr) 2021-06-11
EP3083629B1 (en) 2021-03-31
EA032040B1 (ru) 2019-03-29
US9845328B2 (en) 2017-12-19
PL223869B1 (pl) 2016-11-30
US20160311827A1 (en) 2016-10-27
ES2866627T3 (es) 2021-10-19

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