PL4073025T3 - Sole metali i ich zastosowania - Google Patents

Sole metali i ich zastosowania

Info

Publication number
PL4073025T3
PL4073025T3 PL20897654.8T PL20897654T PL4073025T3 PL 4073025 T3 PL4073025 T3 PL 4073025T3 PL 20897654 T PL20897654 T PL 20897654T PL 4073025 T3 PL4073025 T3 PL 4073025T3
Authority
PL
Poland
Prior art keywords
applications
metal salts
salts
metal
Prior art date
Application number
PL20897654.8T
Other languages
English (en)
Inventor
Stephen Wald
Eduardo J. Martinez
Samuel STRATFORD
Amanda BUIST
Joseph Benson
Jonathan LOUGHREY
Original Assignee
Inspirna, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inspirna, Inc. filed Critical Inspirna, Inc.
Publication of PL4073025T3 publication Critical patent/PL4073025T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL20897654.8T 2019-12-13 2020-12-11 Sole metali i ich zastosowania PL4073025T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962947968P 2019-12-13 2019-12-13
PCT/US2020/064456 WO2021119397A1 (en) 2019-12-13 2020-12-11 Metal salts and uses thereof

Publications (1)

Publication Number Publication Date
PL4073025T3 true PL4073025T3 (pl) 2024-09-16

Family

ID=76320705

Family Applications (1)

Application Number Title Priority Date Filing Date
PL20897654.8T PL4073025T3 (pl) 2019-12-13 2020-12-11 Sole metali i ich zastosowania

Country Status (14)

Country Link
US (4) US11174220B2 (pl)
EP (1) EP4073025B1 (pl)
JP (1) JP7689964B2 (pl)
CN (1) CN114728875A (pl)
AU (1) AU2020401286A1 (pl)
CA (1) CA3161274A1 (pl)
ES (1) ES2982346T3 (pl)
HU (1) HUE067466T2 (pl)
MX (1) MX2022007164A (pl)
PL (1) PL4073025T3 (pl)
RS (1) RS65646B1 (pl)
TW (1) TWI888447B (pl)
WO (1) WO2021119397A1 (pl)
ZA (1) ZA202206588B (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3150729A1 (en) * 2019-09-11 2021-03-18 Inspirna, Inc. Methods of treating cancer
TWI888447B (zh) 2019-12-13 2025-07-01 美商因思博納公司 金屬鹽及其用途

Family Cites Families (204)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL275743A (pl) 1961-03-20
DD150456A5 (de) 1979-03-01 1981-09-02 Ciba Geigy Ag Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols
DE2951400A1 (de) 1979-12-20 1981-07-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n,n'-diarylaethylendiaminen oder n, n',n''-triaryldiaethylen-triaminen
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
DK196688A (da) 1987-04-28 1988-10-29 Fujisawa Pharmaceutical Co Bicykliske forbindelser og fremgangsmaade til fremstilling deraf
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5324731A (en) 1989-02-14 1994-06-28 Amira, Inc. Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated
US5676978A (en) 1989-02-14 1997-10-14 Amira, Inc. Methods of inhibiting undesirable cell growth using a combination of a cyclocreatine compound and a hyperplastic inhibitory agent
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5215882A (en) 1989-11-30 1993-06-01 Ortho Diagnostic Systems, Inc. Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
CA2111503A1 (en) 1993-12-15 1995-06-16 Mcgill University Apolipoprotein e polymorphism and alzheimer's disease
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
DE69621507T2 (de) 1995-03-28 2003-01-09 Japan Science And Technology Corp., Kawaguchi Verfahren zur molekularen Indexierung von Genen unter Verwendung von Restriktionsenzymen
US5843974A (en) 1995-06-06 1998-12-01 Eli Lilly And Company Methods of inhibiting melanoma using Benzothiophenes as cytotoxic agents per se
US5958342A (en) 1996-05-17 1999-09-28 Incyte Pharmaceuticals, Inc. Jet droplet device
US6060240A (en) 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
US5945289A (en) 1996-12-20 1999-08-31 Lehrer; Steven Method for detecting prostate cancer by apolipoprotein E (Apo-E) genotyping
US6090556A (en) 1997-04-07 2000-07-18 Japan Science & Technology Corporation Method for quantitatively determining the expression of a gene
US5994076A (en) 1997-05-21 1999-11-30 Clontech Laboratories, Inc. Methods of assaying differential expression
US20030153541A1 (en) 1997-10-31 2003-08-14 Robert Dudley Novel anticholesterol compositions and method for using same
ATE338118T1 (de) 1997-12-12 2006-09-15 Univ Western Ontario Neues peptid, apoep1.b, zusammensetzungen und verwendungen davon
US6004755A (en) 1998-04-07 1999-12-21 Incyte Pharmaceuticals, Inc. Quantitative microarray hybridizaton assays
US6048695A (en) 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US6906069B1 (en) 1999-01-08 2005-06-14 Amgen Inc. LXR modulators
US6316503B1 (en) 1999-03-15 2001-11-13 Tularik Inc. LXR modulators
CN1187364C (zh) 1999-04-30 2005-02-02 亚其发展公司 类固醇衍生物
US8257750B2 (en) 1999-04-30 2012-09-04 Kibow Biotech, Inc. Calcium carbonate compositions for preventing or treating hyperphosphatemia
WO2001066534A2 (en) 2000-03-09 2001-09-13 Abbott Laboratories Cyclic and bicyclic diamino histamine-3 receptor antagonists
US6716622B2 (en) 2000-07-18 2004-04-06 Uab Research Foundation Tissue-specific self-inactivating gene therapy vector
WO2002013594A1 (en) 2000-08-17 2002-02-21 Northland Seed & Grain Corp. Method for minimizing contamination of crops and products derived therefrom
US20030027335A1 (en) 2000-09-07 2003-02-06 Ruley H. Earl Genome engineering by cell-permeable DNA site-specific recombinases
WO2002024632A2 (en) 2000-09-18 2002-03-28 Glaxo Group Limited Substituted aminopropoxyaryl derivatives useful as agonists for lxr
ES2248231T3 (es) * 2001-01-31 2006-03-16 Pfizer Products Inc. Derivados de eteres utiles como inhibidores de las isozimas pde4.
EP1385868A4 (en) 2001-02-08 2004-12-08 Univ Chicago STEROID DERIVATIVE
JP4309661B2 (ja) 2001-05-03 2009-08-05 ザ ユニバーシティー オブ シカゴ 肝臓ｘ受容体
US6908934B2 (en) 2001-06-11 2005-06-21 Merck & Co., Inc. Therapeutic compounds for treating dyslipidemic conditions
JP2003033179A (ja) 2001-07-05 2003-02-04 Asahi Kasei Corp 可逆的遺伝子導入ベクター
WO2003031408A2 (en) 2001-10-08 2003-04-17 Eli Lilly And Company Tricyclic compounds useful for modulating lxr
JP2005513026A (ja) 2001-11-15 2005-05-12 インサイト サン ディエゴ インコーポレイテッド 高コレステロール血症、異脂肪血症および他の代謝障害；癌、および他の疾患を治療するｎ−置換複素環
CA2467165A1 (en) 2001-11-21 2003-06-05 Merck & Co., Inc. Therapeutic compounds for treating dyslipidemic conditions
CA2471311A1 (en) 2001-12-21 2003-07-24 Pharmacia Corporation Aromatic thioether liver x-receptor modulators
ES2367539T3 (es) 2001-12-21 2011-11-04 X-Ceptor Therapeutics, Inc. Moduladores heterocíclicos de receptores nucleares.
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
EP1465869B1 (en) 2001-12-21 2013-05-15 Exelixis Patent Company LLC Modulators of lxr
US7560586B2 (en) * 2002-03-27 2009-07-14 Smithkline Beecham Corporation Acid and ester compounds and methods of using the same
EP1575495A4 (en) 2002-03-27 2009-12-02 Smithkline Beecham Corp COMPOUNDS AND METHODS
AU2003220558A1 (en) 2002-03-27 2004-06-03 Smithkline Beecham Corporation Amide compounds and methods of using the same
US20050171084A1 (en) 2002-03-27 2005-08-04 Cairns William J. Methods of treatment with lxr modulators
WO2003090746A1 (en) 2002-04-23 2003-11-06 Chugai Seiyaku Kabushiki Kaisha 1,3-thiazoles as lxr modulators in the treatment of cardiovascular diseases
WO2003090732A1 (en) 2002-04-23 2003-11-06 Chugai Seiyaku Kabushiki Kaisha Lxr modulators for the treatment of cardiovascular diseases
WO2003090869A1 (en) 2002-04-23 2003-11-06 Chugai Seiyaku Kabushiki Kaisha Lxr modulators
WO2003099769A1 (en) 2002-05-24 2003-12-04 Pharmacia Corporation Anilino liver x-receptor modulators
MXPA04011690A (es) 2002-05-24 2005-03-31 Pharmacia Corp Moduladores de receptor x de higado de sulfona.
WO2004009091A1 (en) 2002-06-17 2004-01-29 Glaxo Group Limited Purine derivatives as liver x receptor agonists
TW200401770A (en) 2002-06-18 2004-02-01 Sankyo Co Fused-ring pyrimidin-4(3H)-one derivatives, processes for the preparation and uses thereof
ATE470722T1 (de) 2002-07-19 2010-06-15 Althea Technologies Inc Strategien zur genexpressionsanalyse
US7125865B2 (en) 2002-07-25 2006-10-24 Merck & Co., Inc. Therapeutic compounds for treating dyslipidemic conditions
JP2005534710A (ja) 2002-08-07 2005-11-17 ノバルティス アクチエンゲゼルシャフト Ａｐｏｅ遺伝子型を基準とした痴呆を処置するための方法
EP1407774A1 (en) 2002-09-10 2004-04-14 LION Bioscience AG 2-Amino-4-quinazolinones as LXR nuclear receptor binding compounds
AU2003272552A1 (en) 2002-09-17 2004-04-08 Pharmacia Corporation Aromatic liver x-receptor modulators
WO2004058717A1 (en) 2002-12-20 2004-07-15 X-Ceptor Therapeutics, Inc. Isoquinolinone derivatives and their use as therapeutic agents
WO2004072042A2 (en) 2003-02-12 2004-08-26 Carex S.A. Quinoline derivative and their use for modulation of lxr activity
WO2004072046A2 (en) 2003-02-12 2004-08-26 Carex S.A. Quinoline derivatives and their use for modulation of lxr activity
WO2004072041A1 (en) 2003-02-12 2004-08-26 Care X S.A. Tetrahydroquinolines as agonists of liver- x receptors
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
US20040216178A1 (en) 2003-03-03 2004-10-28 Jones Stephen N Regulation of mdm2 function
GB0316232D0 (en) 2003-07-11 2003-08-13 Astrazeneca Ab Therapeutic agents
GB0316237D0 (en) 2003-07-11 2003-08-13 Astrazeneca Ab Therapeutic agents
WO2005007877A2 (en) 2003-07-18 2005-01-27 University Of Massachusetts Regulatable promoters for synthesis of small hairpin rna
MXPA06001566A (es) 2003-08-12 2006-05-15 Amgen Inc Compuestos arilsulfonamidobencilicos.
EA009374B1 (ru) 2003-09-03 2007-12-28 Кова Ко., Лтд. Активирующее ppar соединение и содержащая его фармацевтическая композиция
JP2006193426A (ja) 2003-09-05 2006-07-27 Sankyo Co Ltd 置換された縮環ピリミジン−４（３ｈ）−オン化合物
BRPI0415563A (pt) 2003-10-20 2007-01-02 Nsgene As método para o tratamento do mal de parkinson, uso de um vetor viral, vetor de expressão viral, composição farmacêutica, célula hospedeira isolada, linhagem de células de empacotamento, mamìfero não humano quimérico, dispositivo de cultura celular implantável, cápsula biocompatìvel, método para tratamento de uma doença do sistema nervoso, célula de mamìfero, e, método para produzir neurturin ou um seu equivalente funcional
US20050113419A1 (en) 2003-10-31 2005-05-26 Huang Shaei Y. Therapeutic compounds for treating dyslipidemic conditions
AU2004298486A1 (en) 2003-12-12 2005-06-30 Wyeth Quinolines useful in treating cardiovascular disease
FR2865736B1 (fr) 2004-02-02 2006-07-14 Synt Em Inhibiteurs de l'angiogenese, compositions les contenant et leur utilisation pour le traitement des maladies liees a une deregulation de l'angiogenese
WO2005077122A2 (en) 2004-02-11 2005-08-25 Irm Llc Compounds and compositions as lxr modulators
AU2005211809B2 (en) 2004-02-11 2009-02-12 Irm Llc Compounds and compositions as LXR modulators
ES2314633T3 (es) 2004-03-26 2009-03-16 F. Hoffmann-La Roche Ag Tetrahidrocarbazoles y derivados.
DE602005015962D1 (de) 2004-05-03 2009-09-24 Hoffmann La Roche Indolylderivate als liver-x-rezeptormodulatoren
WO2005112620A2 (en) 2004-05-18 2005-12-01 Massachusetts Institute Of Technology A cre-lox based method for conditional rna interference
WO2005113499A1 (ja) 2004-05-20 2005-12-01 Sankyo Company, Limited インドール化合物
JP4809338B2 (ja) 2004-06-28 2011-11-09 エフ．ホフマン−ラ ロシュ アーゲー 新規なヘキサフルオロイソプロパノール誘導体
TW200606133A (en) 2004-06-30 2006-02-16 Sankyo Co Substituted benzene compounds
WO2006004030A1 (ja) 2004-07-02 2006-01-12 Sankyo Company, Limited 組織因子産生抑制剤
CN1980665A (zh) 2004-07-07 2007-06-13 默克公司 吡唑酰胺衍生物，包含这些化合物的组合物和使用方法
EP1773781A2 (en) 2004-08-03 2007-04-18 Wyeth Indazoles useful in treating cardiovascular diseases
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
US20060178398A1 (en) 2004-09-16 2006-08-10 Adams Alan D Therapeutic compounds for treating dyslipidemic conditions
ATE415385T1 (de) 2004-10-01 2008-12-15 Hoffmann La Roche Hexafluorisopropanolsubstituierte etherderivate
TW200619191A (en) 2004-10-27 2006-06-16 Sankyo Co Phenyl compounds with more than 2 substitutes
WO2006066779A1 (en) 2004-12-22 2006-06-29 F.Hoffmann-La Roche Ag Novel cyclohexane derivatives
SE0500056D0 (sv) 2005-01-10 2005-01-10 Astrazeneca Ab Therapeutic agents 4
US20090029945A2 (en) 2005-01-10 2009-01-29 Astrazeneca Ab Non-Anilinic Derivatives of Isothiazol-3(2H)-Thione 1,1-Dioxides As Liver X Receptor Modulators
SE0500058D0 (sv) 2005-01-10 2005-01-10 Astrazeneca Ab Therapeutic agents 5
SE0500055D0 (sv) 2005-01-10 2005-01-10 Astrazeneca Ab Therapeutic agents 3
JP2008526841A (ja) 2005-01-10 2008-07-24 アストラゼネカ アクチボラグ 肝臓ｘ受容体調節因子としてのイソチアゾール−３（２ｈ）−オン１，１−ジオキシドのアニリン系誘導体
JP2006232703A (ja) 2005-02-23 2006-09-07 Dai Ichi Seiyaku Co Ltd フェニルエーテル誘導体及びそれを用いた医薬
RU2007131400A (ru) 2005-03-01 2009-04-10 Вайет (Us) Соединения циннолина и их применение в качестве модуляторов х-рецепторов печени
US8318760B2 (en) 2005-03-21 2012-11-27 Merck Sharp & Dohme Corp. Substituted aryl and heteroaryl derivatives, compositions containing such compounds and methods of use
WO2006109633A1 (ja) 2005-04-07 2006-10-19 Daiichi Sankyo Company, Limited 置換インドール化合物
BRPI0612287A8 (pt) 2005-06-27 2019-01-22 Exelixis Inc composição para uso farmacêutico no tratamento de doenças através da medicina nuclear e métodos de uso e para modulação de atividade de receptor nuclear
WO2007022563A1 (en) 2005-08-24 2007-03-01 Graham Scott Package with bitter taste aversive agent for infant deterrant
SI1934174T1 (sl) 2005-10-07 2011-08-31 Exelixis Inc Inhibitorji MEK in postopki za njihovo uporabo
US7790745B2 (en) 2005-10-21 2010-09-07 Bristol-Myers Squibb Company Tetrahydroisoquinoline LXR Modulators
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
WO2007050271A2 (en) 2005-10-25 2007-05-03 Wyeth 5-lipoxygenase modulators
CN101309915A (zh) 2005-11-14 2008-11-19 Irm责任有限公司 作为lxr调节剂的化合物和组合物
WO2007081335A1 (en) 2006-01-12 2007-07-19 Merck & Co., Inc. Therapeutic compounds for treating dyslipidemic conditions
ATE495197T1 (de) 2006-03-20 2011-01-15 Cepep Iii Ab Chimäre konstrukte zwischen auf krebs zielenden peptiden und zellpenetrierenden peptiden gekoppelt an antikrebsmittel und/oder diagnostische mittel
WO2007110755A1 (en) * 2006-03-27 2007-10-04 Medical Therapies Limited Prophylaxis or treatment of cardiovascular inflammation
WO2008011071A2 (en) 2006-07-19 2008-01-24 The Regents Of The University Of California Interactions of hedgehog and liver x receptor signaling pathways
WO2008027988A2 (en) 2006-08-31 2008-03-06 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods of treating estrogen-responsive conditions by orphan nuclear receptor activation
TW200825054A (en) 2006-10-18 2008-06-16 Wyeth Corp Quinoline compounds
US8324367B2 (en) 2006-11-03 2012-12-04 Medtronic, Inc. Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
EP1925621A1 (en) * 2006-11-27 2008-05-28 Novartis AG Crystalline forms of zoledronic acid
KR20090086084A (ko) 2006-11-30 2009-08-10 코와 가부시키가이샤 치환 카르비놀 화합물
KR20090094125A (ko) 2006-12-08 2009-09-03 엑셀리시스, 인코포레이티드 Ｌｘｒ 및 ｆｘｒ 조절자
JP2008179562A (ja) 2007-01-24 2008-08-07 Kowa Co Ｌｘｒアゴニスト
US8993628B2 (en) 2007-02-23 2015-03-31 City Of Hope Synthetic ligands selective for LXRβ over LXRα, identification and methods of use thereof
EP2142517A2 (en) 2007-05-18 2010-01-13 Wyeth Quinazoline compounds
WO2009005793A2 (en) 2007-06-29 2009-01-08 Avi Biopharma, Inc. Tissue specific peptide conjugates and methods
JP5220858B2 (ja) 2007-08-13 2013-06-26 エフ．ホフマン−ラ ロシュ アーゲー 新規ピペラジンアミド誘導体
TW200922582A (en) 2007-08-20 2009-06-01 Organon Nv N-benzyl, N'-arylcarbonylpiperazine derivatives
US8039493B2 (en) 2007-09-27 2011-10-18 Hoffmann-La Roche Inc. Biaryl sulfonamide derivatives
EP2623599B1 (en) 2007-10-04 2019-01-02 Roche Innovation Center Copenhagen A/S Micromirs
US7902147B2 (en) 2007-11-05 2011-03-08 Duke University Chronic lymphocytic leukemia prognosis and treatment
CA2705152C (en) 2007-11-09 2016-10-11 Peregrine Pharmaceuticals, Inc. Anti-vegf antibody compositions and methods
WO2009075836A2 (en) 2007-12-10 2009-06-18 The Brigham And Women's Hospital, Inc. Rap variants for drug delivery
EP2071509A1 (en) 2007-12-13 2009-06-17 Gemalto SA Method and apparatus to mark a document using a combination between guilloches and watermarking, method and apparatus to read previous combination
US20100324073A1 (en) 2007-12-21 2010-12-23 Wyeth Llc Pyrazolo [1,5-A] Pyrimidine Compounds
WO2009086130A1 (en) 2007-12-21 2009-07-09 Wyeth Imidazo [1,2-b] pyridazine compounds as modulators of liver x receptors
JP2011507905A (ja) 2007-12-21 2011-03-10 ワイス・エルエルシー ベンズイミダゾール化合物
EP2231660A1 (en) 2007-12-21 2010-09-29 Wyeth LLC Imidazo [1,2-a] pyridine compounds
US7919509B2 (en) 2008-02-29 2011-04-05 Kowa Company, Ltd. 2-oxochromene derivatives
US7951822B2 (en) 2008-03-31 2011-05-31 Kowa Company, Ltd. 1,3-dihydroisobenzofuran derivatives
JP5371118B2 (ja) 2008-04-30 2013-12-18 興和株式会社 キノリン化合物
TW201006816A (en) 2008-05-15 2010-02-16 Organon Nv Hexafluoroisopropanol derivatives
US20090311187A1 (en) 2008-05-29 2009-12-17 Bristol-Myers Squibb Company Methods for predicting patient response to modulation of the Co-stimulatory pathway
AU2009252615B2 (en) 2008-05-29 2013-08-15 Kowa Company, Ltd. Substituted carbinol compound having cyclic linker
US8063088B2 (en) 2008-06-11 2011-11-22 Hoffmann-La Roche Inc. Imidazolidine derivatives
WO2010002982A1 (en) 2008-07-01 2010-01-07 Cognosci, Inc. Methods of treating cancer with apoe peptides
TW201022230A (en) 2008-08-28 2010-06-16 Organon Nv 1-(4-ureidobenzoyl)piperazine derivatives
FR2935380B1 (fr) 2008-08-29 2010-09-10 Galderma Res & Dev Nouveaux composes hexafluoro-2-biphenyl-isopropanol, modulateurs des recepteurs de type lxrs, leur procede de preparation et leur application comme medicaments en medecine humaine ou veterinaire ainsi qu'en cosmetique.
US8613367B2 (en) 2008-08-29 2013-12-24 Saint-Gobain Performance Plastics Corporation Sealing assembly and method of making such assembly
US8394969B2 (en) 2008-09-26 2013-03-12 Merck Sharp & Dohme Corp. Cyclic benzimidazole derivatives useful as anti-diabetic agents
US8552154B2 (en) 2008-09-26 2013-10-08 Emory University Anti-PD-L1 antibodies and uses therefor
EP2367801A1 (en) 2008-11-19 2011-09-28 Wyeth LLC Polar quinazolines as liver x receptors ( lxrs ) modulators
WO2010101888A2 (en) 2009-03-02 2010-09-10 Biocure Pharma, Llc Methods and compositions for treatment of tumor metastasis
KR101671046B1 (ko) 2009-04-29 2016-10-31 코와 가부시키가이샤 헤테로환 링커를 갖는 카르비놀 화합물
KR101676704B1 (ko) 2009-05-28 2016-11-16 엑셀리시스 페이턴트 컴퍼니 엘엘씨 Ｌｘｒ 조절자
US8829213B2 (en) 2009-07-29 2014-09-09 The University Of Chicago Liver X receptor agonists
KR101636958B1 (ko) 2009-09-11 2016-07-06 주식회사 대웅제약 우루소데옥시콜린산-합성하이드로탈사이트-유드라짓 혼성체, 이를 함유하는 약학 조성물 및 그 제조방법
TWI513695B (zh) 2009-10-27 2015-12-21 Merck Sharp & Dohme （１，１，１，３，３，３－六氟－２－羥基丙－２－基）苯基衍生物
EP2499142B1 (en) 2009-11-09 2016-09-21 Advinus Therapeutics Limited Substituted fused pyrimidine compounds, its preparation and uses thereof
AU2010327597B2 (en) 2009-12-04 2014-06-19 Nissan Chemical Industries, Ltd. 2-Pyridone compounds
WO2011103175A2 (en) 2010-02-16 2011-08-25 The Regents Of The University Of California Oxysterols that activate liver x receptor signaling and inhibit hedgehog signaling
WO2011115892A1 (en) 2010-03-15 2011-09-22 Griffin Patrick R Modulators of the retinoic acid receptor-related orphan receptors
US9421218B2 (en) 2010-04-13 2016-08-23 New York University Compositions and methods for treatment of melanoma
US20130090258A1 (en) 2010-06-16 2013-04-11 National University Corporation Hamamatsu University School Of Medicines Method for detecting colorectal tumor
JP2013531007A (ja) 2010-07-08 2013-08-01 ワイス・エルエルシー 皮膚障害の治療に有用な新規キノリンエステル
EP2474617A1 (en) 2011-01-11 2012-07-11 InteRNA Technologies BV Mir for treating neo-angiogenesis
US20130004481A1 (en) 2011-01-12 2013-01-03 Boehringer Ingelheim International Gmbh Anticancer therapy
US20120231457A1 (en) 2011-03-10 2012-09-13 Nikolaos Tezapsidis Compositions and methods for assessing a genetic risk of developing late-onset alzheimer's disease (load)
US9629910B2 (en) 2011-03-22 2017-04-25 The Brigham And Women's Hospital, Inc. Use of Th9 cells and IL-9 for the treatment of melanoma
AR088728A1 (es) 2011-03-25 2014-07-02 Bristol Myers Squibb Co Moduladores de lxr como prodroga de imidazol
JP2014526506A (ja) 2011-09-15 2014-10-06 ノバルティス アーゲー 中等度肝障害患者の癌治療における４−アミノ−５−フルオロ−３−［６−（４−メチルピペラジン−１−イル）−１ｈ−ベンゾイミダゾール−２−イル］−１ｈ−キノリン−２−オンの使用
WO2013043569A1 (en) 2011-09-20 2013-03-28 Vical Incorporated Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
CN103054844B (zh) 2011-10-18 2014-04-30 中国科学院武汉病毒研究所 一种gw3965在制备治疗或预防丙型肝炎药物中的应用
MX351610B (es) 2011-10-18 2017-10-20 Inst Nat Sante Rech Med Sales acidas de adicion de 5alfa-hidroxi-6beta-[2-(1h-imidazol-4-i l)etilamino]colestan-3beta-ol.
JP6157492B2 (ja) 2011-11-24 2017-07-05 アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） ステロール誘導体の調製方法
SG10201607345YA (en) 2012-03-02 2016-11-29 Ralexar Therapeutics Inc Liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions
CN104203951B (zh) 2012-03-16 2016-11-02 生命医药公司 肝x受体调节剂
WO2013138568A1 (en) 2012-03-16 2013-09-19 Vitae Pharmaceuticals, Inc. Liver x reception modulators
AU2013302861A1 (en) 2012-08-13 2015-03-05 The Rockefeller University Treatment and diagnosis of melanoma
CN105209039B (zh) 2013-03-15 2018-06-22 百时美施贵宝公司 Lxr调节剂
JP6066860B2 (ja) 2013-08-05 2017-01-25 株式会社クボタ 草刈機
WO2015065505A1 (en) 2013-10-29 2015-05-07 Duke University Use of cyp27a1 inhibitors, statin, or lxr antagonists alone or in combination with conventional therapy for the treatment of breast cancer
WO2015106164A1 (en) 2014-01-10 2015-07-16 Rgenix, Inc. Lxr agonists and uses thereof
ES2860648T5 (es) 2014-02-07 2024-11-27 Global Blood Therapeutics Inc Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1H-pirazol-5-il)piridin-3-il)metoxi)benzaldehído
JP6626085B2 (ja) 2014-07-15 2019-12-25 ザ・ジョンズ・ホプキンス・ユニバーシティー 骨髄由来抑制細胞の抑制及び免疫チェックポイント阻害の方法
US20190125745A1 (en) * 2014-12-17 2019-05-02 Rgenix, Inc. Treatment and diagnosis of cancer
WO2016149299A1 (en) 2015-03-16 2016-09-22 Epinova Therapeutics Corp. Therapeutic compounds that suppress protein arginine methyltransferase activity for reducing tumor cell proliferation
US20170056352A1 (en) 2015-08-25 2017-03-02 Rgenix, Inc. PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF
US20190330335A1 (en) 2015-10-06 2019-10-31 Alector Llc Anti-trem2 antibodies and methods of use thereof
US11058700B2 (en) 2015-10-28 2021-07-13 City Of Hope Macrocyclic lactones and uses thereof as modulators of purinergic receptors
EP3402477A4 (en) 2016-01-11 2019-08-21 The Rockefeller University METHOD FOR THE TREATMENT OF DISEASES RELATED TO MYELOID-DERIVED SUPPRESSOR CELLS
MA43977A (fr) 2016-02-05 2018-12-12 Taiho Pharmaceutical Co Ltd Méthode de traitement de patients atteints de cancer souffrant d'insuffisance rénale grave
WO2017161188A1 (en) 2016-03-16 2017-09-21 The Regents Of The University Of California Detection and treatment of anti-pd-1 therapy resistant metastatic melanomas
WO2017181163A2 (en) 2016-04-16 2017-10-19 Oncocyte Corporation Methods and compositions for detection and diagnosis of breast cancer
MY192158A (en) 2016-09-14 2022-08-03 Abbvie Biotherapeutics Inc Anti-pd-1 antibodies and their uses
WO2018160178A1 (en) 2017-03-01 2018-09-07 Rgenix, Inc. Pharmaceutically acceptable salts of b-guanidinopropionic acid with improved properties and uses thereof
EP3589280B1 (en) 2017-03-03 2024-02-07 Inspirna, Inc. Formulations with improved stability
CA3078981A1 (en) * 2017-11-21 2019-05-31 Rgenix, Inc. Polymorphs and uses thereof
CN109251974A (zh) 2018-02-14 2019-01-22 重庆京因生物科技有限责任公司 基于poct模式的apoe2和apoe4基因型快速检测试剂盒
JP7654202B2 (ja) 2019-02-28 2025-04-01 ザ ロックフェラー ユニバーシティー がんの予後及び治療におけるａｐｏｅ遺伝子型決定
KR20220022050A (ko) 2019-03-29 2022-02-23 바이오엔테크 유에스 인크. 지속적인 임상 이익을 위한 암 바이오마커
TWI888447B (zh) 2019-12-13 2025-07-01 美商因思博納公司 金屬鹽及其用途

Also Published As

Publication number Publication date
US12258303B2 (en) 2025-03-25
ES2982346T3 (es) 2024-10-15
EP4073025A4 (en) 2023-07-05
US11459292B2 (en) 2022-10-04
EP4073025B1 (en) 2024-03-27
US11174220B2 (en) 2021-11-16
EP4073025A1 (en) 2022-10-19
HUE067466T2 (hu) 2024-10-28
WO2021119397A1 (en) 2021-06-17
NZ789129A (en) 2025-03-28
JP2023509845A (ja) 2023-03-10
CN114728875A (zh) 2022-07-08
EP4073025C0 (en) 2024-03-27
JP7689964B2 (ja) 2025-06-09
ZA202206588B (en) 2023-11-29
US20240174595A1 (en) 2024-05-30
RS65646B1 (sr) 2024-07-31
AU2020401286A1 (en) 2022-06-23
TW202136188A (zh) 2021-10-01
WO2021119397A9 (en) 2021-10-14
CA3161274A1 (en) 2021-06-17
US20220041541A1 (en) 2022-02-10
US11878956B2 (en) 2024-01-23
TWI888447B (zh) 2025-07-01
US20230095288A1 (en) 2023-03-30
US20210179539A1 (en) 2021-06-17
MX2022007164A (es) 2022-09-12

Similar Documents

Publication Publication Date Title
IL283639A (en) Kif18a inhibitors
DK3999506T3 (da) Parp1-hæmmere
EP3843714C0 (en) CD73 INHIBITORS
EP4007756C0 (en) KIF18A INHIBITORS
DK3746446T3 (da) PRC2-inhibitorer
DK4051688T3 (da) Cd73-hæmmere
IL281514A (en) O-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors
DK3956322T3 (da) Jak1-selektiv kinaseinhibitor
EP4077580C0 (en) Refrigerant
EP3978468A4 (en) CONNECTION AND COMPOSITION
EP3940230A4 (en) COMPRESSOR
EP4027073C0 (en) REFRIGERATION DEVICE
EP4083249A4 (en) ALLOY
EP3976797A4 (en) ANTI-CRISPR INHIBITORS
DK3932909T3 (da) Benzoindazolonforbindelse og mellemprodukt heraf
EP3913768A4 (en) Compressor
CA189120S (fr) Pendentif
EP3794362C0 (en) METAL DETECTOR
PL4073025T3 (pl) Sole metali i ich zastosowania
EP3601449A4 (en) SYNERGISTIC METAL POLYCARBOXYLATE CORROSION INHIBITORS
EP3933198C0 (en) COMPRESSOR
EP4027017A4 (en) COMPRESSOR
EP3683077C0 (de) Kühlvorrichtung
CA189017S (fr) Basketball
EP3833374C0 (en) PROTEASOME INHIBITORS