PL408793A1 - Co-crystal 4-amino-N-(4,6-dimethylpyrimidin-2-yl)-benzene-1-sulfonamide - quinolin-2-carboxylic acid and method for producing it - Google Patents
Co-crystal 4-amino-N-(4,6-dimethylpyrimidin-2-yl)-benzene-1-sulfonamide - quinolin-2-carboxylic acid and method for producing itInfo
- Publication number
- PL408793A1 PL408793A1 PL40879314A PL40879314A PL408793A1 PL 408793 A1 PL408793 A1 PL 408793A1 PL 40879314 A PL40879314 A PL 40879314A PL 40879314 A PL40879314 A PL 40879314A PL 408793 A1 PL408793 A1 PL 408793A1
- Authority
- PL
- Poland
- Prior art keywords
- sulfonamide
- benzene
- amino
- crystal
- carboxylic acid
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 4
- RGOULDANZMRZPG-UHFFFAOYSA-N N1=C(C=CC2=CC=CC=C12)C(=O)O.NC1=CC=C(C=C1)S(=O)(=O)NC1=NC(=CC(=N1)C)C Chemical compound N1=C(C=CC2=CC=CC=C12)C(=O)O.NC1=CC=C(C=C1)S(=O)(=O)NC1=NC(=CC(=N1)C)C RGOULDANZMRZPG-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 2
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- SMWDFEZZVXVKRB-UHFFFAOYSA-N anhydrous quinoline Natural products N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 1
- 239000004570 mortar (masonry) Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Wynalazek dotyczy kokryształu 4-amino-N-(4,6-dimetylopirymidyn-2-ylo)-benzeno-1-sulfonamid - kwas chinolino-2-karboksylowy o wzorze 1, który znajduje zastosowanie w przemyśle farmaceutycznym. Wynalazek ujawnia również sposób wytwarzania kokryształu o wzorze 1, charakteryzujący się tym, że 0,1 mmol 4-amino-N-(4,6-dimetylopirydymidyn-2-ylo)-benzeno-1 -sulfonamidu i 0,1 mmol kwasu chinolino-2-karboksylowego umieszcza się w moździerzu agatowym, po czym całość uciera się z 1 kroplą rozpuszczalnika wybranego spośród: metanolu, etanolu, acetonitrylu przez około 1 minutę. Całość rozpuszcza się w 8 ml wybranego rozpuszczalnika, miesza szybkością 100-300 rpm przez około 2 do 10 minut w temperaturze pokojowej i tak przygotowany roztwór przesącza, a następnie odparowuje w warunkach temperatury pokojowej, i po 3 do 5 dni. Uzyskuje się pomarańczowe kryształy.The invention relates to a 4-amino-N- (4,6-dimethylpyrimidin-2-yl) -benzene-1-sulfonamide-quinoline-2-carboxylic acid co-crystal of formula 1 which is used in the pharmaceutical industry. The invention also discloses a method for producing a co-crystal of Formula 1, characterized in that 0.1 mmol of 4-amino-N- (4,6-dimethylpyridimidin-2-yl) benzene-1-sulfonamide and 0.1 mmol of quinoline acid The 2-carboxylic acid is placed in an agate mortar and the whole is triturated with 1 drop of a solvent selected from methanol, ethanol, acetonitrile for about 1 minute. It is dissolved in 8 ml of the selected solvent, stirred at 100-300 rpm for about 2 to 10 minutes at room temperature and the solution thus prepared is filtered and then evaporated at room temperature and after 3 to 5 days. Orange crystals are obtained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL40879314A PL408793A1 (en) | 2014-07-10 | 2014-07-10 | Co-crystal 4-amino-N-(4,6-dimethylpyrimidin-2-yl)-benzene-1-sulfonamide - quinolin-2-carboxylic acid and method for producing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL40879314A PL408793A1 (en) | 2014-07-10 | 2014-07-10 | Co-crystal 4-amino-N-(4,6-dimethylpyrimidin-2-yl)-benzene-1-sulfonamide - quinolin-2-carboxylic acid and method for producing it |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL408793A1 true PL408793A1 (en) | 2015-04-13 |
Family
ID=52782002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL40879314A PL408793A1 (en) | 2014-07-10 | 2014-07-10 | Co-crystal 4-amino-N-(4,6-dimethylpyrimidin-2-yl)-benzene-1-sulfonamide - quinolin-2-carboxylic acid and method for producing it |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL408793A1 (en) |
-
2014
- 2014-07-10 PL PL40879314A patent/PL408793A1/en unknown
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