PL408794A1 - Co-crystal 4-amino-N-(4,6-dimethylpyrimidin-2-yl)-benzene-1-sulfonamide - 4-nitrophenyl acetic acid and method for producing it - Google Patents
Co-crystal 4-amino-N-(4,6-dimethylpyrimidin-2-yl)-benzene-1-sulfonamide - 4-nitrophenyl acetic acid and method for producing itInfo
- Publication number
- PL408794A1 PL408794A1 PL40879414A PL40879414A PL408794A1 PL 408794 A1 PL408794 A1 PL 408794A1 PL 40879414 A PL40879414 A PL 40879414A PL 40879414 A PL40879414 A PL 40879414A PL 408794 A1 PL408794 A1 PL 408794A1
- Authority
- PL
- Poland
- Prior art keywords
- sulfonamide
- benzene
- amino
- crystal
- dimethylpyrimidin
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 4
- GOGTUHYQYIZLFN-UHFFFAOYSA-N [N+](=O)([O-])C1=CC=C(C=C1)CC(=O)O.NC1=CC=C(C=C1)S(=O)(=O)NC1=NC(=CC(=N1)C)C Chemical compound [N+](=O)([O-])C1=CC=C(C=C1)CC(=O)O.NC1=CC=C(C=C1)S(=O)(=O)NC1=NC(=CC(=N1)C)C GOGTUHYQYIZLFN-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- YBADLXQNJCMBKR-UHFFFAOYSA-N (4-nitrophenyl)acetic acid Chemical compound OC(=O)CC1=CC=C([N+]([O-])=O)C=C1 YBADLXQNJCMBKR-UHFFFAOYSA-N 0.000 abstract 1
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 239000004570 mortar (masonry) Substances 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
Wynalazek dotyczy kokryształu 4-amino-N-(4,6-dimetylopirymidyn-2-ylo)-benzeno-1-sulfonamid - kwas 4-nitrofenylooctowy o wzorze 1, który znajduje zastosowanie w przemyśle farmaceutycznym. Wynalazek ujawnia również sposób wytwarzania kokryształu o wzorze 1, polegający na tym, że 0,1 mmol 4-amino-N-(4,6-dimetylopirydymidyn-2-ylo)-benzeno-1-sulfonamidu i 0,1 mmol kwasu 4-nitrofenylooctowego umieszcza się w moździerzu agatowym, po czym całość uciera się z 1 kroplą rozpuszczalnika wybranego spośród: metanolu, etanolu, acetonitrylu przez około 1 minutę. Następnie całość rozpuszcza się w 8 - 10 ml wybranego rozpuszczalnika, miesza szybkością 100 - 300 rpm przez około 2 do 10 minut w temperaturze w zakresie od 30 do 60°C, a klarowny roztwór pozostawia w celu powolnego odparowania rozpuszczalnika w warunkach temperatury pokojowej. Po czym po 2 do 4 dniach uzyskuje się żółte kryształy, które następnie przemywa się 5 ml aprotonowym rozpuszczalnikiem.The invention relates to a 4-amino-N- (4,6-dimethylpyrimidin-2-yl) -benzene-1-sulfonamide-4-nitrophenylacetic acid co-crystal of formula 1 which is used in the pharmaceutical industry. The invention also discloses a method for producing a co-crystal of Formula 1, wherein 0.1 mmol of 4-amino-N- (4,6-dimethylpyridimidin-2-yl) benzene-1-sulfonamide and 0.1 mmol of 4- nitrophenylacetate is placed in an agate mortar and the whole is triturated with 1 drop of a solvent selected from methanol, ethanol, acetonitrile for about 1 minute. The whole is then dissolved in 8-10 ml of the selected solvent, mixed at 100-300 rpm for about 2 to 10 minutes at a temperature in the range of 30 to 60 ° C, and the clear solution is allowed to slowly evaporate the solvent at room temperature. After 2 to 4 days yellow crystals are obtained, which are then washed with 5 ml aprotic solvent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL40879414A PL408794A1 (en) | 2014-07-10 | 2014-07-10 | Co-crystal 4-amino-N-(4,6-dimethylpyrimidin-2-yl)-benzene-1-sulfonamide - 4-nitrophenyl acetic acid and method for producing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL40879414A PL408794A1 (en) | 2014-07-10 | 2014-07-10 | Co-crystal 4-amino-N-(4,6-dimethylpyrimidin-2-yl)-benzene-1-sulfonamide - 4-nitrophenyl acetic acid and method for producing it |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL408794A1 true PL408794A1 (en) | 2015-04-13 |
Family
ID=52782003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL40879414A PL408794A1 (en) | 2014-07-10 | 2014-07-10 | Co-crystal 4-amino-N-(4,6-dimethylpyrimidin-2-yl)-benzene-1-sulfonamide - 4-nitrophenyl acetic acid and method for producing it |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL408794A1 (en) |
-
2014
- 2014-07-10 PL PL40879414A patent/PL408794A1/en unknown
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