PL406455A1 - 4-amino-N- (4,6-dimethylpyridimidin-2-yl) -benzene-1-sulfonamide-2-amino-5-nitropyridine co-crystal and its method of preparation - Google Patents
4-amino-N- (4,6-dimethylpyridimidin-2-yl) -benzene-1-sulfonamide-2-amino-5-nitropyridine co-crystal and its method of preparationInfo
- Publication number
- PL406455A1 PL406455A1 PL406455A PL40645513A PL406455A1 PL 406455 A1 PL406455 A1 PL 406455A1 PL 406455 A PL406455 A PL 406455A PL 40645513 A PL40645513 A PL 40645513A PL 406455 A1 PL406455 A1 PL 406455A1
- Authority
- PL
- Poland
- Prior art keywords
- amino
- nitropyridine
- sulfonamide
- benzene
- dimethylpyridimidin
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 2
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- -1 4-amino-N- (4,6-dimethylpyrimidin-2-yl) -benzene-1-sulfonamide-2-amino-2-amino-5-nitropyridine Chemical compound 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- UGSBCCAHDVCHGI-UHFFFAOYSA-N 5-nitropyridin-2-amine Chemical compound NC1=CC=C([N+]([O-])=O)C=N1 UGSBCCAHDVCHGI-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000004570 mortar (masonry) Substances 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
Landscapes
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem wynalazku jest 4-amino-N-(4,6-dimetylopirymidyn-2-ylo)-benzeno- 1-sulfonamid-2-amino- 2-amino-5-nitropirydyna o wzorze 1, która znajduje zastosowanie w przemyśle farmaceutycznym. Przedmiotem wynalazku jest też sposób wytwarzania 4-amino-N-(4,6-dimetylopirydymi-dyn-2-ylo)-benzeno-1 -sulfonamid-2-amino-5-nitropirydyny o wzorze 1, charakteryzujący się tym, że 0,1 mmola 4-amino-N-(4,6-dimetylopirydymidyn-2-ylo)-benzeno-1 -sulfonamidu i 0,1 mmola 2-amino-5-nitropirydyny stosunku 1:1 uciera się w moździerzu z 1 kroplą rozpuszczalnika wybranego z grupy metanol, etanol, acetonitryl przez czas około 1 minuty, po czym całość rozpuszcza się w 10 ml wybranego z powyżej wskazanej grupy rozpuszczalnika, a następnie roztwór miesza się z szybkością 100-300 rpm przez czas od 2 do 10 minut w temperaturze w zakresie od 60 do 90°C, dalej całość przesącza się odparowuje w temperaturze pokojowej, i po 2 do 4 dni uzyskuje się żółte kryształy w postaci igieł.The present invention relates to 4-amino-N- (4,6-dimethylpyrimidin-2-yl) -benzene-1-sulfonamide-2-amino-2-amino-5-nitropyridine of formula 1, which is used in the pharmaceutical industry. The invention also relates to a process for preparing 4-amino-N- (4,6-dimethylpyridimidin-din-2-yl) benzene-1-sulfonamide-2-amino-5-nitropyridine of formula 1, characterized in that 1 mmol of 4-amino-N- (4,6-dimethylpyridimidin-2-yl) -benzene-1-sulfonamide and 0.1 mmol of 1: 1 ratio of 2-amino-5-nitropyridine are rubbed in a mortar with 1 drop of selected solvent from the group of methanol, ethanol, acetonitrile for about 1 minute, after which the whole is dissolved in 10 ml of the solvent group selected from the above indicated, and then the solution is mixed at a speed of 100-300 rpm for a period of 2 to 10 minutes at a temperature in the range from 60 to 90 ° C, further filtered and evaporated at room temperature, and after 2 to 4 days yellow crystals in the form of needles are obtained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL406455A PL406455A1 (en) | 2013-12-10 | 2013-12-10 | 4-amino-N- (4,6-dimethylpyridimidin-2-yl) -benzene-1-sulfonamide-2-amino-5-nitropyridine co-crystal and its method of preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL406455A PL406455A1 (en) | 2013-12-10 | 2013-12-10 | 4-amino-N- (4,6-dimethylpyridimidin-2-yl) -benzene-1-sulfonamide-2-amino-5-nitropyridine co-crystal and its method of preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL406455A1 true PL406455A1 (en) | 2014-07-07 |
Family
ID=51063174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL406455A PL406455A1 (en) | 2013-12-10 | 2013-12-10 | 4-amino-N- (4,6-dimethylpyridimidin-2-yl) -benzene-1-sulfonamide-2-amino-5-nitropyridine co-crystal and its method of preparation |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL406455A1 (en) |
-
2013
- 2013-12-10 PL PL406455A patent/PL406455A1/en unknown
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