PL413953A1 - Method for producing optically pure (+)-(R)-7-hydroxyflavanone - Google Patents

Method for producing optically pure (+)-(R)-7-hydroxyflavanone

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Publication number
PL413953A1
PL413953A1 PL413953A PL41395315A PL413953A1 PL 413953 A1 PL413953 A1 PL 413953A1 PL 413953 A PL413953 A PL 413953A PL 41395315 A PL41395315 A PL 41395315A PL 413953 A1 PL413953 A1 PL 413953A1
Authority
PL
Poland
Prior art keywords
hydroxyflavanone
optically pure
hours
organic solvent
water
Prior art date
Application number
PL413953A
Other languages
Polish (pl)
Other versions
PL227310B1 (en
Inventor
Edyta Kostrzewa-Susłow
Monika Dymarska
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL413953A priority Critical patent/PL227310B1/en
Publication of PL413953A1 publication Critical patent/PL413953A1/en
Publication of PL227310B1 publication Critical patent/PL227310B1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Sposób wytwarzania (+)-(R)-7-hydroksyflawanonu, polega na tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Aspergillus niger IBR, następnie po upływie co najmniej 48 godzin do hodowli wprowadza się substrat, którym jest (±)-octan 7-hydroksyflawanonu o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą. Transformację prowadzi się przy ciągłym wstrząsaniu, co najwyżej 30 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie. Związek ten może znaleźć zastosowanie jako antyoksydant w przemyśle spożywczym oraz jako składnik preparatów farmaceutycznych i kosmetycznych.The method of producing (+) - (R) -7-hydroxyflavanone is that the Aspergillus niger IBR strain is introduced into the medium suitable for filamentous fungi, then after at least 48 hours the substrate which is (±) is introduced into the culture. 7-hydroxyflavanone acetate (1), dissolved in a water-miscible organic solvent. The transformation is carried out with continuous shaking, at most 30 hours, after which the product is extracted with a water-immiscible organic solvent and purified by chromatography. This compound can be used as an antioxidant in the food industry and as an ingredient in pharmaceutical and cosmetic preparations.

PL413953A 2015-09-14 2015-09-14 Method for producing optically pure (+)-(R)-7-hydroxyflavanone PL227310B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL413953A PL227310B1 (en) 2015-09-14 2015-09-14 Method for producing optically pure (+)-(R)-7-hydroxyflavanone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL413953A PL227310B1 (en) 2015-09-14 2015-09-14 Method for producing optically pure (+)-(R)-7-hydroxyflavanone

Publications (2)

Publication Number Publication Date
PL413953A1 true PL413953A1 (en) 2017-03-27
PL227310B1 PL227310B1 (en) 2017-11-30

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ID=58360238

Family Applications (1)

Application Number Title Priority Date Filing Date
PL413953A PL227310B1 (en) 2015-09-14 2015-09-14 Method for producing optically pure (+)-(R)-7-hydroxyflavanone

Country Status (1)

Country Link
PL (1) PL227310B1 (en)

Also Published As

Publication number Publication date
PL227310B1 (en) 2017-11-30

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