PL417882A1 - Method for producing optically clean (+)-(R)-7-hydroxyflavanone - Google Patents

Method for producing optically clean (+)-(R)-7-hydroxyflavanone

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Publication number
PL417882A1
PL417882A1 PL417882A PL41788216A PL417882A1 PL 417882 A1 PL417882 A1 PL 417882A1 PL 417882 A PL417882 A PL 417882A PL 41788216 A PL41788216 A PL 41788216A PL 417882 A1 PL417882 A1 PL 417882A1
Authority
PL
Poland
Prior art keywords
hydroxyflavanone
producing optically
hours
organic solvent
water
Prior art date
Application number
PL417882A
Other languages
Polish (pl)
Other versions
PL234084B1 (en
Inventor
Edyta Kostrzewa-Susłow
Monika Dymarska
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL417882A priority Critical patent/PL234084B1/en
Publication of PL417882A1 publication Critical patent/PL417882A1/en
Publication of PL234084B1 publication Critical patent/PL234084B1/en

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób wytwarzania (+)-(R)-7-hydroksyflawanonu, który charakteryzuje się tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Aspergillus niger CH 11/21, następnie po upływie co najmniej 48 godzin do hodowli wprowadza się substrat, którym jest (±)-propionian 7-hydroksyflawanonu o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą. Transformację prowadzi się przy ciągłym wstrząsaniu, co najwyżej 80 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie.The subject of the application is a method for producing (+) - (R) -7-hydroxyflavanone, which is characterized in that the strain Aspergillus niger CH 11/21 is introduced into the medium suitable for filamentous fungi, then after at least 48 hours the culture is introduced 7-hydroxyflavanone (±) -propionate (1) substrate, dissolved in a water-miscible organic solvent. The transformation is carried out with continuous shaking, at most 80 hours, after which the product is extracted with a water-immiscible organic solvent and purified by chromatography.

PL417882A 2016-07-08 2016-07-08 Method for producing optically clean (+)-(R)-7-hydroxyflavanone PL234084B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL417882A PL234084B1 (en) 2016-07-08 2016-07-08 Method for producing optically clean (+)-(R)-7-hydroxyflavanone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL417882A PL234084B1 (en) 2016-07-08 2016-07-08 Method for producing optically clean (+)-(R)-7-hydroxyflavanone

Publications (2)

Publication Number Publication Date
PL417882A1 true PL417882A1 (en) 2018-01-15
PL234084B1 PL234084B1 (en) 2020-01-31

Family

ID=60937354

Family Applications (1)

Application Number Title Priority Date Filing Date
PL417882A PL234084B1 (en) 2016-07-08 2016-07-08 Method for producing optically clean (+)-(R)-7-hydroxyflavanone

Country Status (1)

Country Link
PL (1) PL234084B1 (en)

Also Published As

Publication number Publication date
PL234084B1 (en) 2020-01-31

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