PL415635A1 - Concentration of zinc in blood and changes within GPX1 gene, as risk factors for breast or ovary cancers in carriers of BRCA1 mutation, subjected to the uterine adnexa removal operation - Google Patents
Concentration of zinc in blood and changes within GPX1 gene, as risk factors for breast or ovary cancers in carriers of BRCA1 mutation, subjected to the uterine adnexa removal operationInfo
- Publication number
- PL415635A1 PL415635A1 PL415635A PL41563515A PL415635A1 PL 415635 A1 PL415635 A1 PL 415635A1 PL 415635 A PL415635 A PL 415635A PL 41563515 A PL41563515 A PL 41563515A PL 415635 A1 PL415635 A1 PL 415635A1
- Authority
- PL
- Poland
- Prior art keywords
- concentration
- zinc
- gpx1
- breast
- serum
- Prior art date
Links
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title abstract 6
- 239000011701 zinc Substances 0.000 title abstract 6
- 229910052725 zinc Inorganic materials 0.000 title abstract 6
- 101150072950 BRCA1 gene Proteins 0.000 title abstract 3
- 206010006187 Breast cancer Diseases 0.000 title abstract 3
- 208000026310 Breast neoplasm Diseases 0.000 title abstract 3
- 206010061535 Ovarian neoplasm Diseases 0.000 title abstract 3
- 210000000481 breast Anatomy 0.000 title abstract 3
- 230000035772 mutation Effects 0.000 title abstract 3
- 108700020463 BRCA1 Proteins 0.000 title abstract 2
- 102000036365 BRCA1 Human genes 0.000 title abstract 2
- 101150115464 GPX1 gene Proteins 0.000 title abstract 2
- 239000000969 carrier Substances 0.000 title abstract 2
- 239000008280 blood Substances 0.000 title 1
- 210000004369 blood Anatomy 0.000 title 1
- 210000002966 serum Anatomy 0.000 abstract 5
- 102100033039 Glutathione peroxidase 1 Human genes 0.000 abstract 2
- 101001014936 Homo sapiens Glutathione peroxidase 1 Proteins 0.000 abstract 2
- 239000012620 biological material Substances 0.000 abstract 2
- 108700040618 BRCA1 Genes Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102200155575 rs1050450 Human genes 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
W zgłoszeniu stwierdzono, że występuje korelacja między genotypem genu GPX1 (rs 1050450), poziomem cynku w surowicy a ryzykiem raka piersi lub jajnika u nosicielek mutacji w genie BRCA1 poddanych w przeszłości zabiegowi usunięcia przydatków. Przedmiotem zgłoszenia jest sposób określenia ryzyka raka, charakteryzujący się tym, że obejmuje ocenę konstytucyjnej zmiany w genie GPX1 Pro200Leu (rs 1050450) oraz ocenę stężenia cynku w próbce biologicznej badanej nosicielki mutacji w genie BRCA1 poddanej adnexektomii, przy czym kombinacja poszczególnych genotypów z określonym stężeniem cynku wskazuje znacząco obniżone ryzyko rozwoju raków piersi lub jajnika: - dla genotypu GPX1 CC przy stężeniu cynku w surowicy ? 1025 µg/l (lub stężeniu w dowolnym materiale biologicznym odpowiadającym stężeniu w surowicy); - dla genotypu GPX1 nCC przy stężeniu cynku w surowicy 750-950 µg/l (lub stężeniu w dowolnym materiale biologicznym odpowiadającym stężeniu w surowicy).The report found that there was a correlation between the GPX1 gene genotype (rs 1050450), serum zinc levels and the risk of breast or ovarian cancer in carriers of the BRCA1 mutation who had undergone adnexectomy surgery in the past. The subject of the application is a method of determining the risk of cancer, characterized in that it includes the assessment of the constitutional change in the GPX1 Pro200Leu gene (rs 1050450) and the assessment of zinc concentration in the biological sample of the examined carrier of mutations in the BRCA1 gene subjected to adnexectomy, the combination of individual genotypes with a specific concentration of zinc indicates a significantly reduced risk of developing breast or ovarian cancers: - for GPX1 CC genotype at serum zinc? 1025 µg / l (or concentration in any biological material corresponding to the serum concentration); - for the GPX1 nCC genotype at a serum zinc concentration of 750-950 µg / l (or the concentration in any biological material corresponding to the serum concentration).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL415635A PL415635A1 (en) | 2015-12-30 | 2015-12-30 | Concentration of zinc in blood and changes within GPX1 gene, as risk factors for breast or ovary cancers in carriers of BRCA1 mutation, subjected to the uterine adnexa removal operation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL415635A PL415635A1 (en) | 2015-12-30 | 2015-12-30 | Concentration of zinc in blood and changes within GPX1 gene, as risk factors for breast or ovary cancers in carriers of BRCA1 mutation, subjected to the uterine adnexa removal operation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL415635A1 true PL415635A1 (en) | 2017-07-03 |
Family
ID=59201371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL415635A PL415635A1 (en) | 2015-12-30 | 2015-12-30 | Concentration of zinc in blood and changes within GPX1 gene, as risk factors for breast or ovary cancers in carriers of BRCA1 mutation, subjected to the uterine adnexa removal operation |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL415635A1 (en) |
-
2015
- 2015-12-30 PL PL415635A patent/PL415635A1/en unknown
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