PL415645A1 - Concentration of zinc in blood and changes within MMP1 gene as risk factors for cancers in women - Google Patents
Concentration of zinc in blood and changes within MMP1 gene as risk factors for cancers in womenInfo
- Publication number
- PL415645A1 PL415645A1 PL415645A PL41564515A PL415645A1 PL 415645 A1 PL415645 A1 PL 415645A1 PL 415645 A PL415645 A PL 415645A PL 41564515 A PL41564515 A PL 41564515A PL 415645 A1 PL415645 A1 PL 415645A1
- Authority
- PL
- Poland
- Prior art keywords
- zinc
- concentration
- women
- risk
- serum
- Prior art date
Links
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title abstract 6
- 239000011701 zinc Substances 0.000 title abstract 6
- 229910052725 zinc Inorganic materials 0.000 title abstract 6
- 206010028980 Neoplasm Diseases 0.000 title abstract 5
- 101150014058 MMP1 gene Proteins 0.000 title abstract 2
- 239000008280 blood Substances 0.000 title 1
- 210000004369 blood Anatomy 0.000 title 1
- 210000002966 serum Anatomy 0.000 abstract 5
- 201000011510 cancer Diseases 0.000 abstract 3
- 239000012620 biological material Substances 0.000 abstract 2
- 101001013150 Homo sapiens Interstitial collagenase Proteins 0.000 abstract 1
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
W zgłoszeniu stwierdzono, że występuje korelacja między genotypem genu MMP1 (rs 1799750), poziomem cynku w surowicy a ryzykiem raków u kobiet. Przedmiotem zgłoszenia jest sposób określania ryzyka raka, charakteryzuje się tym, że obejmuje ocenę konstytucyjnej zmiany w genie MMP1 -1607 1G > 2G (rs 1799750) oraz ocenę poziomu cynku w próbce biologicznej badanej kobiety, przy czym kombinacja poszczególnych genotypów z określonym poziomem cynku wskazuje znacząco zwiększone lub zmniejszone ryzyko rozwoju raków, przy czym uznaje się, że ryzyko raków u kobiet: - dla genotypu MMP1n2G/2G przy stężeniu cynku w surowicy < 1000 µg/l (lub stężeniu w dowolnym materiale biologicznym odpowiadającym stężeniu w surowicy) jest podwyższone; - dla genotypu MMP12G/2G przy stężeniu cynku w surowicy < 1000 µg/l (lub stężeniu w dowolnym materiale biologicznym odpowiadającym stężeniu w surowicy) jest obniżone.The report found that there was a correlation between the genotype of the MMP1 gene (rs 1799750), serum zinc and the risk of cancer in women. The subject of the application is a method for determining the risk of cancer, it is characterized in that it includes the assessment of the constitutional change in the MMP1 -1607 1G> 2G gene (rs 1799750) and the assessment of the level of zinc in the biological sample of the examined woman, where the combination of individual genotypes with a specific level of zinc indicates significantly increased or reduced risk of developing cancers, whereby the risk of cancer in women is considered: - for the MMP1n2G / 2G genotype at serum zinc <1000 µg / l (or concentration in any biological material corresponding to serum concentration); - for the MMP12G / 2G genotype at a serum zinc concentration <1000 µg / l (or in any biological material corresponding to the serum concentration) is reduced.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL415645A PL415645A1 (en) | 2015-12-30 | 2015-12-30 | Concentration of zinc in blood and changes within MMP1 gene as risk factors for cancers in women |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL415645A PL415645A1 (en) | 2015-12-30 | 2015-12-30 | Concentration of zinc in blood and changes within MMP1 gene as risk factors for cancers in women |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL415645A1 true PL415645A1 (en) | 2017-07-03 |
Family
ID=59201406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL415645A PL415645A1 (en) | 2015-12-30 | 2015-12-30 | Concentration of zinc in blood and changes within MMP1 gene as risk factors for cancers in women |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL415645A1 (en) |
-
2015
- 2015-12-30 PL PL415645A patent/PL415645A1/en unknown
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