PL415640A1 - Concentration of iron in blood and changes within HFE gene as risk factors for cancers in women - Google Patents
Concentration of iron in blood and changes within HFE gene as risk factors for cancers in womenInfo
- Publication number
- PL415640A1 PL415640A1 PL415640A PL41564015A PL415640A1 PL 415640 A1 PL415640 A1 PL 415640A1 PL 415640 A PL415640 A PL 415640A PL 41564015 A PL41564015 A PL 41564015A PL 415640 A1 PL415640 A1 PL 415640A1
- Authority
- PL
- Poland
- Prior art keywords
- concentration
- iron
- hfe
- serum
- women
- Prior art date
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title abstract 12
- 229910052742 iron Inorganic materials 0.000 title abstract 6
- 101150065637 Hfe gene Proteins 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 239000008280 blood Substances 0.000 title 1
- 210000004369 blood Anatomy 0.000 title 1
- 210000002966 serum Anatomy 0.000 abstract 5
- 201000011510 cancer Diseases 0.000 abstract 3
- 102000048988 Hemochromatosis Human genes 0.000 abstract 2
- 239000012620 biological material Substances 0.000 abstract 2
- 102200071191 rs1799945 Human genes 0.000 abstract 2
- 239000012472 biological sample Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
W zgłoszeniu stwierdzono, że występuje korelacja między genotypem genu HFE (rs 1799945), stężeniem żelaza w surowicy a ryzykiem raków u kobiet. Przedmiotem zgłoszenia jest sposób określania ryzyka raka. Sposób ten charakteryzuje się tym, że obejmuje ocenę konstytucyjnej zmiany w genie HFE His63Asp (rs1799945) oraz ocenę stężenia żelaza w próbce biologicznej badanej kobiety, przy czym kombinacja poszczególnych genotypów z określonym poziomem żelaza wskazuje na znacząco obniżone ryzyko rozwoju raków: - dla genotypu HFE CC przy stężeniu żelaza w surowicy 975-1125 µg/l (lub stężeniu w dowolnym materiale biologicznym odpowiadającym stężeniu w surowicy); - dla genotypu HFE nCC przy stężeniu żelaza w surowicy 1000-1400 µg/l (lub stężeniu w dowolnym materiale biologicznym odpowiadającym stężeniu w surowicy).The application found a correlation between the HFE gene genotype (rs 1799945), serum iron concentration and the risk of cancer in women. The subject of the notification is how to determine cancer risk. This method is characterized in that it includes the assessment of the constitutional change in the HFE His63Asp gene (rs1799945) and the assessment of iron concentration in the biological sample of the examined woman, where the combination of individual genotypes with a specific iron level indicates a significantly reduced risk of cancer development: - for the HFE CC genotype at a serum iron concentration of 975-1125 µg / l (or concentration in any biological material corresponding to the serum concentration); - for the HFE nCC genotype at a serum iron concentration of 1000-1400 µg / l (or concentration in any biological material corresponding to serum concentration).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL415640A PL415640A1 (en) | 2015-12-30 | 2015-12-30 | Concentration of iron in blood and changes within HFE gene as risk factors for cancers in women |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL415640A PL415640A1 (en) | 2015-12-30 | 2015-12-30 | Concentration of iron in blood and changes within HFE gene as risk factors for cancers in women |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL415640A1 true PL415640A1 (en) | 2017-07-03 |
Family
ID=59201399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL415640A PL415640A1 (en) | 2015-12-30 | 2015-12-30 | Concentration of iron in blood and changes within HFE gene as risk factors for cancers in women |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL415640A1 (en) |
-
2015
- 2015-12-30 PL PL415640A patent/PL415640A1/en unknown
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