PL422936A1 - 7,4'-diisopropoxy-naringenin oxime and method for obtaining 7,4'-diisopropoxy-naringenin oxime - Google Patents
7,4'-diisopropoxy-naringenin oxime and method for obtaining 7,4'-diisopropoxy-naringenin oximeInfo
- Publication number
- PL422936A1 PL422936A1 PL422936A PL42293617A PL422936A1 PL 422936 A1 PL422936 A1 PL 422936A1 PL 422936 A PL422936 A PL 422936A PL 42293617 A PL42293617 A PL 42293617A PL 422936 A1 PL422936 A1 PL 422936A1
- Authority
- PL
- Poland
- Prior art keywords
- oxime
- naringenin
- diisopropoxy
- obtaining
- formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract 1
- 229940040526 anhydrous sodium acetate Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012043 crude product Substances 0.000 abstract 1
- 239000005457 ice water Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Przedmiotem zgłoszenia jest oksym 7,4'-diizopropoksynaringeniny o wzorze 2 oraz sposób otrzymywania tego związku. Sposób ten polega na tym, że do substratu, którym jest 7,4'-diizopropoksynaringenina o wzorze 1 dodaje się chlorowodorek hydroksyloaminy oraz bezwodny octan sodu w stosunku molowym co najmniej 1:1,5:1,5 oraz minimalną ilość alkoholu, co stanowi mieszaninę reakcyjną, którą zabezpiecza się przed dostępem światła i pozostawia w temperaturze od 35°C do 45°C na okres od 24 do 48 godzin przy ciągłym mieszaniu, po czym mieszaninę wylewa się do wody z lodem, wytrącony osad sączy się pod zmniejszonym ciśnieniem, a następnie otrzymany surowy produkt oczyszcza się.The subject of the application is 7,4'-diisopropoxynaringenine oxime of formula 2 and the method of obtaining this compound. The method consists in adding hydroxylamine hydrochloride and anhydrous sodium acetate in a molar ratio of at least 1: 1.5: 1.5 and a minimum amount of alcohol to the substrate, which is 7,4'-diisopropoxynaringenin of formula 1 the reaction mixture, which is protected from light and left at a temperature of 35 ° C to 45 ° C for 24 to 48 hours with continuous stirring, after which the mixture is poured into ice-water, the precipitate is filtered under reduced pressure, and then the obtained crude product is purified.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL422936A PL235502B1 (en) | 2017-09-21 | 2017-09-21 | 7,4'-diisopropoxy-naringenin oxime and method for obtaining 7,4'-diisopropoxy-naringenin oxime |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL422936A PL235502B1 (en) | 2017-09-21 | 2017-09-21 | 7,4'-diisopropoxy-naringenin oxime and method for obtaining 7,4'-diisopropoxy-naringenin oxime |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL422936A1 true PL422936A1 (en) | 2019-03-25 |
| PL235502B1 PL235502B1 (en) | 2020-08-24 |
Family
ID=65799947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL422936A PL235502B1 (en) | 2017-09-21 | 2017-09-21 | 7,4'-diisopropoxy-naringenin oxime and method for obtaining 7,4'-diisopropoxy-naringenin oxime |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL235502B1 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL399895A1 (en) * | 2012-07-11 | 2013-01-07 | Uniwersytet Przyrodniczy We Wroclawiu | Isoxanthohumol oxime and method of obtaining of the isoxanthohumol oxime |
-
2017
- 2017-09-21 PL PL422936A patent/PL235502B1/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL399895A1 (en) * | 2012-07-11 | 2013-01-07 | Uniwersytet Przyrodniczy We Wroclawiu | Isoxanthohumol oxime and method of obtaining of the isoxanthohumol oxime |
Non-Patent Citations (1)
| Title |
|---|
| CHAVI YENJAI, SUCHANA WANICH, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS VOLUME 20, ISSUE 9, 1 May 2010 (2010-05-01) * |
Also Published As
| Publication number | Publication date |
|---|---|
| PL235502B1 (en) | 2020-08-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL422935A1 (en) | 7,4'-didecanoxy-naringenin oxime and method for obtaining 7,4'-didecanoxy-naringenin oxime | |
| AR118124A2 (en) | PROCESS FOR THE PREPARATION OF A PDE4 INHIBITOR | |
| PL422926A1 (en) | 7-propoxy-naringenin oxime and method for obtaining 7-propoxy-naringenin oxime | |
| PL422932A1 (en) | 7-isopropoxy-naringenin oxime and method for obtaining 7-isopropoxy-naringenin oxime | |
| PL422931A1 (en) | 7-decanoxy-naringenin-oxime and method for obtaining 7-decanoxy-naringenin-oxime | |
| PL434616A1 (en) | 7,4'-di-O-hexylnaringenin oxime and method of its preparation | |
| PL421047A1 (en) | 7,4'-didodecanoxy-naringenin-oxime and method for obtaining 7,4'-didodecanoxy-naringenin-oxime | |
| BR112014013411A2 (en) | cyclic urea derivatives as androgen receptor antagonists | |
| PL422936A1 (en) | 7,4'-diisopropoxy-naringenin oxime and method for obtaining 7,4'-diisopropoxy-naringenin oxime | |
| PL422933A1 (en) | 7,4'-dibutoxy-naringenin oxime and method for obtaining 7,4'-dibutoxy-naringenin oxime | |
| PL421041A1 (en) | 7,4'-dipentoxy-naringenin-oxime and method for obtaining 7,4'-dipentoxy-naringenin-oxime | |
| PL421043A1 (en) | 7,4'-dimethoxy-naringenin-oxime and method for obtaining 7,4'-dimethoxy-naringenin-oxime | |
| PL422930A1 (en) | 7-butoxy-naringenin-oxime and method for obtaining 7-butoxy-naringenin-oxime | |
| PL421033A1 (en) | 7-pentoxy-naringenin-oxime and method for obtaining 7-petoxy-naringenin-oxime | |
| PL421031A1 (en) | 7-ethoxy-naringenin-oxime and method for obtaining 7-ethoxy-naringenin-oxime | |
| PL422961A1 (en) | 7,4'-dipropoxy-naringenin oxime and method for obtaining 7,4'-dipropoxy-naringenin oxime | |
| PL421034A1 (en) | 7,4'-diethoxy-naringenin-oxime and method for obtaining 7,4'-diethoxy-naringenin-oxime | |
| PL422927A1 (en) | 5,7,4'-tripropoxy-naringenin oxime and method for obtaining 5,7,4'-tripropoxy naringenin oxime | |
| PL443474A1 (en) | 7,4'-di-O-nonylnaringenin oxime and method of obtaining 7,4'-di-O-nonylnaringenin oxime | |
| PL421042A1 (en) | 5,7,4'-triethoxy-naringenin-oxime and method for obtaining 5,7,4'-triethoxy naringenin-oxime | |
| PL443473A1 (en) | 7,4'-di-O-heptylnaringenin oxime and method of obtaining 7,4'-di-O-heptylnaringenin oxime | |
| PL443475A1 (en) | 7,4'-di-O-octylnaringenin oxime and method of obtaining 7,4'-di-O-octylnaringenin oxime | |
| PL443479A1 (en) | 7-O-heptylnaringenin oxime and method of obtaining 7-O-heptylnaringenin oxime | |
| PL443480A1 (en) | 7-O-nonylnaringenin oxime and method of obtaining 7-O-nonylnaringenin oxime | |
| PL443481A1 (en) | 7-O-octylnaringenin oxime and method of obtaining 7-O-octylnaringenin oxime |