PL443473A1 - 7,4'-di-O-heptylnaringenin oxime and method of obtaining 7,4'-di-O-heptylnaringenin oxime - Google Patents

7,4'-di-O-heptylnaringenin oxime and method of obtaining 7,4'-di-O-heptylnaringenin oxime

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Publication number
PL443473A1
PL443473A1 PL443473A PL44347323A PL443473A1 PL 443473 A1 PL443473 A1 PL 443473A1 PL 443473 A PL443473 A PL 443473A PL 44347323 A PL44347323 A PL 44347323A PL 443473 A1 PL443473 A1 PL 443473A1
Authority
PL
Poland
Prior art keywords
heptylnaringenin
oxime
obtaining
formula
mixture
Prior art date
Application number
PL443473A
Other languages
Polish (pl)
Other versions
PL247536B1 (en
Inventor
Joanna Kozłowska
Anna Duda-Madej
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu, Uniwersytet Medyczny Im. Piastów Śląskich We Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL443473A priority Critical patent/PL247536B1/en
Publication of PL443473A1 publication Critical patent/PL443473A1/en
Publication of PL247536B1 publication Critical patent/PL247536B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Przedmiotem zgłoszenia jest oksym 7,4'-di-O-heptylonaringeniny o wzorze 2 oraz sposób otrzymywania oksymu 7,4'-di-O-heptylonaringeniny polegający na tym, że do substratu, którym jest 7,4'-di-O-heptylonaringenina o wzorze 1 dodaje się chlorowodorek hydroksyloaminy oraz bezwodny octan sodu w stosunku molowym co najmniej 1:3:3 oraz minimalną ilość alkoholu, co stanowi mieszaninę reakcyjną, którą pozostawia się w temperaturze od 30°C do 55°C na okres od 6 do 36 godzin przy ciągłym mieszaniu, po czym mieszaninę wylewa się do wody z lodem, wytrącony osad sączy się pod zmniejszonym ciśnieniem, a następnie otrzymany surowy produkt oczyszcza się.The subject of the application is 7,4'-di-O-heptylnaringenin oxime of formula 2 and a method for obtaining 7,4'-di-O-heptylnaringenin oxime by adding 7,4'-di-O- to the substrate, which is 7,4'-di-O- heptynaringenin of formula 1, hydroxylamine hydrochloride and anhydrous sodium acetate are added in a molar ratio of at least 1:3:3 and a minimum amount of alcohol, which constitutes the reaction mixture, which is left at a temperature from 30°C to 55°C for a period of 6 to 36 hours with constant stirring, then the mixture is poured into ice water, the precipitate is filtered under reduced pressure, and then the crude product obtained is purified.

PL443473A 2023-01-13 2023-01-13 7,4'-di-O-heptylonaringenin oxime and method for obtaining 7,4'-di-O-heptylonaringenin oxime PL247536B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL443473A PL247536B1 (en) 2023-01-13 2023-01-13 7,4'-di-O-heptylonaringenin oxime and method for obtaining 7,4'-di-O-heptylonaringenin oxime

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL443473A PL247536B1 (en) 2023-01-13 2023-01-13 7,4'-di-O-heptylonaringenin oxime and method for obtaining 7,4'-di-O-heptylonaringenin oxime

Publications (2)

Publication Number Publication Date
PL443473A1 true PL443473A1 (en) 2024-07-15
PL247536B1 PL247536B1 (en) 2025-07-21

Family

ID=91899592

Family Applications (1)

Application Number Title Priority Date Filing Date
PL443473A PL247536B1 (en) 2023-01-13 2023-01-13 7,4'-di-O-heptylonaringenin oxime and method for obtaining 7,4'-di-O-heptylonaringenin oxime

Country Status (1)

Country Link
PL (1) PL247536B1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL421047A1 (en) * 2017-03-29 2018-10-08 Uniwersytet Przyrodniczy we Wrocławiu 7,4'-didodecanoxy-naringenin-oxime and method for obtaining 7,4'-didodecanoxy-naringenin-oxime
PL422935A1 (en) * 2017-09-21 2019-03-25 Uniwersytet Przyrodniczy we Wrocławiu 7,4'-didecanoxy-naringenin oxime and method for obtaining 7,4'-didecanoxy-naringenin oxime
PL434616A1 (en) * 2020-07-10 2022-01-17 Uniwersytet Przyrodniczy we Wrocławiu 7,4'-di-O-hexylnaringenin oxime and method of its preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL421047A1 (en) * 2017-03-29 2018-10-08 Uniwersytet Przyrodniczy we Wrocławiu 7,4'-didodecanoxy-naringenin-oxime and method for obtaining 7,4'-didodecanoxy-naringenin-oxime
PL422935A1 (en) * 2017-09-21 2019-03-25 Uniwersytet Przyrodniczy we Wrocławiu 7,4'-didecanoxy-naringenin oxime and method for obtaining 7,4'-didecanoxy-naringenin oxime
PL434616A1 (en) * 2020-07-10 2022-01-17 Uniwersytet Przyrodniczy we Wrocławiu 7,4'-di-O-hexylnaringenin oxime and method of its preparation

Also Published As

Publication number Publication date
PL247536B1 (en) 2025-07-21

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