PL424801A1 - Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of melanoma - Google Patents
Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of melanomaInfo
- Publication number
- PL424801A1 PL424801A1 PL424801A PL42480118A PL424801A1 PL 424801 A1 PL424801 A1 PL 424801A1 PL 424801 A PL424801 A PL 424801A PL 42480118 A PL42480118 A PL 42480118A PL 424801 A1 PL424801 A1 PL 424801A1
- Authority
- PL
- Poland
- Prior art keywords
- extract
- cochlospermum
- application
- angolense
- melanoma
- Prior art date
Links
- 241000480100 Cochlospermum angolense Species 0.000 title abstract 3
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 201000001441 melanoma Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 6
- 238000000605 extraction Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 241000934834 Cochlospermum Species 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003480 eluent Substances 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 230000002879 macerating effect Effects 0.000 abstract 1
- 238000002803 maceration Methods 0.000 abstract 1
- 239000000741 silica gel Substances 0.000 abstract 1
- 229910002027 silica gel Inorganic materials 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób otrzymywania ekstraktu z Cochlospermum angolensis (Borututu), który polega na tym, że sproszkowaną substancję Borututu maceruje się chloroformem, korzystnie dwukrotnie, każdorazowo przez 12 - 72 godzin korzystnie 48 godzin, stosując korzystnie ilości najpierw 1:20, a następnie 1:10, po czym macerat chloroformowy lub połączone maceraty odparowuje się w temperaturze nie przekraczającej 40°C i suchą pozostałość (SP) miesza się z żelem krzemionkowym w proporcjach wagowych od 1:1 do 1:100 korzystnie 1:10 i poddaje się dalszej ekstrakcji w układzie ciecz/ciało stałe przy użyciu heksanu lub octanu etylu i/lub ich mieszaniną korzystnie w proporcji 1:1, po czym po odparowaniu eluentu otrzymuje się frakcję o dużej aktywności przeciwnowotworowej. Przedmiotem zgłoszenia jest także ekstrakt z Cochlospermum angolense Welw. ex Oliv. syn. Maximilianea angolensis (Welw. ex Oliv.), otrzymany na drodze dwustopniowej ekstrakcji: maceracji chloroformem oraz ekstrakcji heksanem lub octanem etylu i/lub ich mieszaniną (Ex2) oraz zastosowanie tego ekstraktu w leczeniu czerniaka.The subject of the application is a method for obtaining an extract of Cochlospermum angolensis (Borututu), which consists in macerating the powdered Borututu substance with chloroform, preferably twice, each time for 12-72 hours, preferably 48 hours, preferably using amounts of 1:20 first and then 1. : 10, then the chloroform macerate or combined macerates are evaporated at a temperature not exceeding 40 ° C and the dry residue (SP) is mixed with silica gel in weight proportions from 1: 1 to 1: 100, preferably 1:10, and further extracted in a liquid / solid system using hexane or ethyl acetate and / or a mixture thereof, preferably in the proportion of 1: 1, then, after evaporation of the eluent, a fraction with high antitumor activity is obtained. The subject of the application is also an extract of Cochlospermum angolense Welw. ex Oliv. son. Maximilianea angolensis (Welw. Ex Oliv.), Obtained by two-step extraction: maceration with chloroform and extraction with hexane or ethyl acetate and / or their mixture (Ex2) and the use of this extract in the treatment of melanoma.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL424801A PL237410B1 (en) | 2018-03-08 | 2018-03-08 | Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of melanoma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL424801A PL237410B1 (en) | 2018-03-08 | 2018-03-08 | Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of melanoma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL424801A1 true PL424801A1 (en) | 2019-09-09 |
| PL237410B1 PL237410B1 (en) | 2021-04-19 |
Family
ID=67844671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL424801A PL237410B1 (en) | 2018-03-08 | 2018-03-08 | Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of melanoma |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL237410B1 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4021428A1 (en) * | 1989-07-14 | 1991-02-28 | Univ Berlin Humboldt | Anthelmintic agent to treat diseases due to worms - contg. carotenoid drug extracted from roots of cochlospermum angolense |
-
2018
- 2018-03-08 PL PL424801A patent/PL237410B1/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4021428A1 (en) * | 1989-07-14 | 1991-02-28 | Univ Berlin Humboldt | Anthelmintic agent to treat diseases due to worms - contg. carotenoid drug extracted from roots of cochlospermum angolense |
Non-Patent Citations (2)
| Title |
|---|
| DIALLO B, STUDIES ON INHIBITORS OF SKIN-TUMOR PROMOTION. INHIBITORY EFFECTS OF TRITERPENES FROM COCHLOSPERMUM TINCTORIUM ON EPSTEIN-BARR VIRUS ACTIVATION, 1989 * |
| S. KALAIGNANA SELVI, ANTI-PROLIFERATIVE ACTIVITY OF GUM KONDAGOGU (COCHLOSPERMUM GOSSYPIUM) - GOLD NANOPARTICLE CONSTRUCTS ON B16F10 MELANOMA CELLS: AN IN VITRO MODEL, 2017 * |
Also Published As
| Publication number | Publication date |
|---|---|
| PL237410B1 (en) | 2021-04-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Wang et al. | Taxifolin enhances osteogenic differentiation of human bone marrow mesenchymal stem cells partially via NF-κB pathway | |
| Yang et al. | Effect of Angelica sinensis on the proliferation of human bone cells | |
| Gođevac et al. | Antioxidant activity of nine Fabaceae species growing in Serbia and Montenegro | |
| IL183292A0 (en) | Composition based on vegetal extracts of ajuga reptans for preventing hair loss, stimulating the growth of hair, regulating the production of sebum | |
| MX2022015865A (en) | Saponin containing extracts prepared from hesperaloe useful in the treatment of non-human animals. | |
| Ouyang et al. | Antioxidant activity and phytochemical composition of Osmanthus fragrans' pulps | |
| Morteza-Semnani et al. | Chemical composition of the essential oil of the flowering aerial parts of Lamium album L. | |
| PL424803A1 (en) | Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of carcinoma of the stomach | |
| Pirvu et al. | Comparative analytical and antioxidant activity studies on a series of Fagus sylvatica L. leaves extracts | |
| Rai et al. | In vitro immuno-stimulatory and anticancer activities of Oroxylum indicum (L.) Kurz.: An evidence for substitution of aerial parts for conservation | |
| PL424802A1 (en) | Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of myeloma | |
| PL424804A1 (en) | Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of hepatocellular carcinoma | |
| WO1999056773A3 (en) | Composition comprising tumor cells and extracts and method of using thereof | |
| Danlami et al. | The antioxidant potentials and phytochemical properties of the Hexane, Ethyl acetate and Ethanolic extracts of Securinega virosa (Euphorbiaceae) leaves | |
| EP3466936B1 (en) | Extraction processes for cynaropicrin present in the leaves of cynara cardunculus l. | |
| KR102093708B1 (en) | A cosmetic composition using Fraxini cortex extract | |
| JPH10310532A (en) | Testosterone-5α-reductase inhibitor | |
| PL446466A1 (en) | Common bean sprout extract (Phaseolus vulgaris L.), method of obtaining it and its use in skin lightening preparations | |
| Falodun et al. | Antiproliferative and Pro-apoptotic activities of the stem bark of Persea Americana (lauraceae) mill in Human Breast Adenocarcinoma Cell Line | |
| Han et al. | Chemical constituents of Medinilla septentrionalis (WW Sm.) HL Li (Melastomataceae) | |
| Soledispa et al. | GC-MS chemical characterization of main components of Smilax domingensis wild in Cuba | |
| Hussain et al. | Antispasmodic and Ca++ antagonist potential of marrubiin, a labdane type diterpene from Phlomis bracteosa | |
| Gao et al. | Bioactivity-guided fractionation of antioxidative constituents of Ligustrum lucidum | |
| TWI735097B (en) | Extraction method of total polyphenols and flavonoids of white flesh dragon fruit | |
| PL446028A1 (en) | Natural cross-linking agent and method for obtaining a natural cross-linking agent |