PL424804A1 - Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of hepatocellular carcinoma - Google Patents
Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of hepatocellular carcinomaInfo
- Publication number
- PL424804A1 PL424804A1 PL424804A PL42480418A PL424804A1 PL 424804 A1 PL424804 A1 PL 424804A1 PL 424804 A PL424804 A PL 424804A PL 42480418 A PL42480418 A PL 42480418A PL 424804 A1 PL424804 A1 PL 424804A1
- Authority
- PL
- Poland
- Prior art keywords
- extract
- cochlospermum
- application
- angolense
- chloroform
- Prior art date
Links
- 241000480100 Cochlospermum angolense Species 0.000 title abstract 3
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 title abstract 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 6
- 238000000605 extraction Methods 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 241000934834 Cochlospermum Species 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003480 eluent Substances 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 230000002879 macerating effect Effects 0.000 abstract 1
- 238000002803 maceration Methods 0.000 abstract 1
- 239000000741 silica gel Substances 0.000 abstract 1
- 229910002027 silica gel Inorganic materials 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób otrzymywania ekstraktu z Cochlospermum angolensis (Borututu), który polega na tym, że sproszkowaną substancję roślinną Borututu maceruje się chloroformem, korzystnie dwukrotnie, każdorazowo przez 12 - 72 godzin korzystnie 48 godzin, stosując korzystnie ilości najpierw 1:20, a następnie 1:10, po czym macerat chloroformowy lub połączone maceraty odparowuje się w temperaturze nie przekraczającej 40°C i suchą pozostałość (SP) miesza się z żelem krzemionkowym w proporcjach wagowych od 1:1 do 1:100 korzystnie 1:10 i poddaje się dalszej ekstrakcji w układzie ciecz/ciało stałe przy użyciu heksanu lub octanu etylu i/lub ich mieszaniną korzystnie w proporcji 1:1, po czym po odparowaniu eluentu otrzymuje się frakcję o dużej aktywności przeciwnowotworowej. Przedmiotem zgłoszenia jest także ekstrakt z Cochlospermum angolense Welw. ex Oliv. syn. Maximilianea angolensis (Welw. ex Oliv.), otrzymany na drodze dwustopniowej ekstrakcji: maceracji chloroformem oraz ekstrakcji heksanem lub octanem etylu i/lub ich mieszaniną (Ex2) oraz zastosowanie tego ekstraktu w leczeniu raka wątrobowokomórkowego.The subject of the application is a method of obtaining an extract of Cochlospermum angolensis (Borututu), which consists in macerating the powdered plant substance Borututu with chloroform, preferably twice, each time for 12-72 hours, preferably 48 hours, using preferably amounts first 1:20 and then 1:10, then the chloroform macerate or combined macerates are evaporated at a temperature not exceeding 40 ° C and the dry residue (SP) is mixed with silica gel in weight proportions from 1: 1 to 1: 100, preferably 1:10, and further processed. liquid / solid extraction with hexane or ethyl acetate and / or a mixture thereof, preferably in the proportion of 1: 1, followed by evaporation of the eluent, a fraction with high antitumor activity. The subject of the application is also an extract of Cochlospermum angolense Welw. ex Oliv. son. Maximilianea angolensis (Welw. Ex Oliv.), Obtained by two-stage extraction: maceration with chloroform and extraction with hexane or ethyl acetate and / or their mixture (Ex2) and the use of this extract in the treatment of hepatocellular carcinoma.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL424804A PL237408B1 (en) | 2018-03-08 | 2018-03-08 | Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of hepatocellular carcinoma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL424804A PL237408B1 (en) | 2018-03-08 | 2018-03-08 | Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of hepatocellular carcinoma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL424804A1 true PL424804A1 (en) | 2019-09-09 |
| PL237408B1 PL237408B1 (en) | 2021-04-19 |
Family
ID=67844605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL424804A PL237408B1 (en) | 2018-03-08 | 2018-03-08 | Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of hepatocellular carcinoma |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL237408B1 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4021428A1 (en) * | 1989-07-14 | 1991-02-28 | Univ Berlin Humboldt | Anthelmintic agent to treat diseases due to worms - contg. carotenoid drug extracted from roots of cochlospermum angolense |
-
2018
- 2018-03-08 PL PL424804A patent/PL237408B1/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4021428A1 (en) * | 1989-07-14 | 1991-02-28 | Univ Berlin Humboldt | Anthelmintic agent to treat diseases due to worms - contg. carotenoid drug extracted from roots of cochlospermum angolense |
Non-Patent Citations (1)
| Title |
|---|
| CARLA PEREIRA, ANTIOXIDANT PROPERTIES , ANTI-HEPATOCELLULAR CARCINOMA ACTIVITY AND HEPATOTOXICITY OF ARTICHOKE, MILK THISTLE AND BORUTUTU, 2013 * |
Also Published As
| Publication number | Publication date |
|---|---|
| PL237408B1 (en) | 2021-04-19 |
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