PL424954A1 - 4'-hydroxy-7-acetamidoflavone and method for producing 4'-hydroxy-7-acetamidoflavone - Google Patents

4'-hydroxy-7-acetamidoflavone and method for producing 4'-hydroxy-7-acetamidoflavone

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Publication number
PL424954A1
PL424954A1 PL424954A PL42495418A PL424954A1 PL 424954 A1 PL424954 A1 PL 424954A1 PL 424954 A PL424954 A PL 424954A PL 42495418 A PL42495418 A PL 42495418A PL 424954 A1 PL424954 A1 PL 424954A1
Authority
PL
Poland
Prior art keywords
acetamidoflavone
hydroxy
hours
formula
organic solvent
Prior art date
Application number
PL424954A
Other languages
Polish (pl)
Other versions
PL237332B1 (en
Inventor
Monika Dymarska
Edyta Kostrzewa-Susłow
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL424954A priority Critical patent/PL237332B1/en
Publication of PL424954A1 publication Critical patent/PL424954A1/en
Publication of PL237332B1 publication Critical patent/PL237332B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest związek o nazwie: 4'-hydroksy-7-acetamidoflawon o wzorze 2 oraz sposób jego otrzymywania. Przedmiotowy sposób ten polega na tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria fumosorosea KCH J2. Po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 7-aminoflawon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą. Transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu co najmniej 96 godzin. Kolejno produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie.The subject of the application is the compound named: 4'-hydroxy-7-acetamidoflavone of formula 2 and the method of its preparation. The subject method consists in introducing the Isaria fumosorosea KCH J2 strain into a medium suitable for filamentous fungi. After at least 72 hours, the substrate is introduced into the culture, which is the 7-aminoflavone of formula I, dissolved in a water-miscible organic solvent. The transformation is carried out at a temperature of 20 to 30 degrees Celsius with continuous shaking for at least 96 hours. Subsequently, the product is extracted with a water-immiscible organic solvent and purified by chromatography.

PL424954A 2018-03-19 2018-03-19 4'-hydroxy-7-acetamidoflavone and method for producing 4'-hydroxy-7-acetamidoflavone PL237332B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL424954A PL237332B1 (en) 2018-03-19 2018-03-19 4'-hydroxy-7-acetamidoflavone and method for producing 4'-hydroxy-7-acetamidoflavone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL424954A PL237332B1 (en) 2018-03-19 2018-03-19 4'-hydroxy-7-acetamidoflavone and method for producing 4'-hydroxy-7-acetamidoflavone

Publications (2)

Publication Number Publication Date
PL424954A1 true PL424954A1 (en) 2019-09-23
PL237332B1 PL237332B1 (en) 2021-04-06

Family

ID=67979730

Family Applications (1)

Application Number Title Priority Date Filing Date
PL424954A PL237332B1 (en) 2018-03-19 2018-03-19 4'-hydroxy-7-acetamidoflavone and method for producing 4'-hydroxy-7-acetamidoflavone

Country Status (1)

Country Link
PL (1) PL237332B1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013020184A1 (en) * 2011-08-11 2013-02-14 Neuprotect Pty Ltd Flavonoid compounds, and methods of use thereof
PL414934A1 (en) * 2015-11-24 2017-06-05 Uniwersytet Przyrodniczy we Wrocławiu Method for obtaining 6-acetamidoflawone
PL414935A1 (en) * 2015-11-24 2017-06-05 Uniwersytet Przyrodniczy we Wrocławiu Method for obtaining 6-acetamidoflawone

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013020184A1 (en) * 2011-08-11 2013-02-14 Neuprotect Pty Ltd Flavonoid compounds, and methods of use thereof
PL414934A1 (en) * 2015-11-24 2017-06-05 Uniwersytet Przyrodniczy we Wrocławiu Method for obtaining 6-acetamidoflawone
PL414935A1 (en) * 2015-11-24 2017-06-05 Uniwersytet Przyrodniczy we Wrocławiu Method for obtaining 6-acetamidoflawone

Also Published As

Publication number Publication date
PL237332B1 (en) 2021-04-06

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