PL439094A1 - 4'-Methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavone and method for preparing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavone - Google Patents

4'-Methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavone and method for preparing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavone

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Publication number
PL439094A1
PL439094A1 PL439094A PL43909421A PL439094A1 PL 439094 A1 PL439094 A1 PL 439094A1 PL 439094 A PL439094 A PL 439094A PL 43909421 A PL43909421 A PL 43909421A PL 439094 A1 PL439094 A1 PL 439094A1
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PL
Poland
Prior art keywords
methylglucopyranosyl
methylene
flavone
formula
hours
Prior art date
Application number
PL439094A
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Polish (pl)
Other versions
PL247106B1 (en
Inventor
Agnieszka Krawczyk-Łebek
Edyta Kostrzewa-Susłow
Monika Dymarska
Tomasz Janeczko
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Uniwersytet Przyrodniczy we Wrocławiu
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Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL439094A priority Critical patent/PL247106B1/en
Publication of PL439094A1 publication Critical patent/PL439094A1/en
Publication of PL247106B1 publication Critical patent/PL247106B1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest 4'-metyleno-O-β-D-(4"-O-metyloglukopiranozylo)-flawon o wzorze 2 oraz sposób wytwarzania 4'-metyleno-O-β-D-(4"-O-metyloglukopiranozylo)-flawonu polegający na tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria fumosorosea KCH J2, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 4'-metyloflawon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie, przy czym 4'-metyleno-O-β-D-(4"-O-metyloglukopiranozylo)-flawon o wzorze 2 znajduje się we frakcji o pośredniej polarności, w drugim paśmie od linii startu.The subject of the application is 4'-methylene-O-β-D-(4"-O-methylglucopyranosyl)-flavone of formula 2 and a method for producing 4'-methylene-O-β-D-(4"-O-methylglucopyranosyl)- in which the strain Isaria fumosorosea KCH J2 is introduced into the substrate suitable for filamentous fungi, and then, after at least 72 hours, the substrate is introduced into the culture, which is 4'-methylflavone of the formula 1, dissolved in an organic solvent miscible with with water, the transformation is carried out at a temperature of 20 to 30 degrees Celsius with continuous shaking for at least 96 hours, after which the product is extracted with a water-immiscible organic solvent and purified by chromatography, whereby 4'-methylene-O-β-D -(4"-O-methylglucopyranosyl)-flavone of formula 2 is found in the fraction of intermediate polarity, in the second band from the starting line.

PL439094A 2021-09-30 2021-09-30 4'-Methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavone and method for preparing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavone PL247106B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL439094A PL247106B1 (en) 2021-09-30 2021-09-30 4'-Methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavone and method for preparing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL439094A PL247106B1 (en) 2021-09-30 2021-09-30 4'-Methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavone and method for preparing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavone

Publications (2)

Publication Number Publication Date
PL439094A1 true PL439094A1 (en) 2023-04-03
PL247106B1 PL247106B1 (en) 2025-05-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL439094A PL247106B1 (en) 2021-09-30 2021-09-30 4'-Methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavone and method for preparing 4'-methylene-O-β-D-(4''-O-methylglucopyranosyl)-flavone

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Country Link
PL (1) PL247106B1 (en)

Also Published As

Publication number Publication date
PL247106B1 (en) 2025-05-12

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