PL426021A1 - 3-O-(β-D-4'-O-methylglucopyranosyl)-17-ethinylestr-17β-ol and method of preparation of 3-O-(β-D-4'-O-methylglucopyranosyl)-17-ethinylestr-17β-ol - Google Patents

3-O-(β-D-4'-O-methylglucopyranosyl)-17-ethinylestr-17β-ol and method of preparation of 3-O-(β-D-4'-O-methylglucopyranosyl)-17-ethinylestr-17β-ol

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Publication number
PL426021A1
PL426021A1 PL426021A PL42602118A PL426021A1 PL 426021 A1 PL426021 A1 PL 426021A1 PL 426021 A PL426021 A PL 426021A PL 42602118 A PL42602118 A PL 42602118A PL 426021 A1 PL426021 A1 PL 426021A1
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PL
Poland
Prior art keywords
methylglucopyranosyl
ethinylestr
preparation
ethynyl ester
methylglucopyranose
Prior art date
Application number
PL426021A
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Polish (pl)
Other versions
PL238289B1 (en
Inventor
Ewa Kozłowska
Iga Franczak
Edyta Kostrzewa-Susłow
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
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Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL426021A priority Critical patent/PL238289B1/en
Publication of PL426021A1 publication Critical patent/PL426021A1/en
Publication of PL238289B1 publication Critical patent/PL238289B1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J17/005—Glycosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/20—Preparation of steroids containing heterocyclic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Zgłoszenie dotyczy 3-O-(ß-D-4'-O-metyloglukopiranozylo)-17-etynyloestr-17ß-olu i sposobu wytwarzania 3-O-(ß-D-4'-O-metyloglukopiranozylo)-17-etynyloestr-17ß-olu. Zgodnie z rozwiązaniem w wyniku działania układu enzymatycznego zawartego w komórkach szczepu Isaria fumosorosea KCh J2, następuje przyłączenie ß-D-4'-O-metyloglukopiranozy do grupy hydroksylowej substratu. Uzyskany w ten sposób produkt wydziela się z wodnej kultury mikroorganizmu, znanym sposobem, przez ekstrakcję rozpuszczalnikiem organicznym niemieszającym się z wodą (chloroform).The application concerns 3-O- (ß-D-4'-O-methylglucopyranosyl) -17-ethynyl ester-17ß-ol and a process for the preparation of 3-O- (ß-D-4'-O-methylglucopyranosyl) -17-ethynyl ester- 17ß-ol. According to the solution, ß-D-4'-O-methylglucopyranose is attached to the hydroxyl group of the substrate as a result of the enzyme system contained in the cells of the Isaria fumosorosea KCh J2 strain. The product obtained in this way is separated from the aqueous culture of the microorganism by a known method by extraction with a water-immiscible organic solvent (chloroform).

PL426021A 2018-06-22 2018-06-22 3-O-(β-D-4'-O-methylglucopyranosyl)-17-ethinylestr-17β-ol and method of preparation of 3-O-(β-D-4'-O-methylglucopyranosyl)-17-ethinylestr-17β-ol PL238289B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL426021A PL238289B1 (en) 2018-06-22 2018-06-22 3-O-(β-D-4'-O-methylglucopyranosyl)-17-ethinylestr-17β-ol and method of preparation of 3-O-(β-D-4'-O-methylglucopyranosyl)-17-ethinylestr-17β-ol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL426021A PL238289B1 (en) 2018-06-22 2018-06-22 3-O-(β-D-4'-O-methylglucopyranosyl)-17-ethinylestr-17β-ol and method of preparation of 3-O-(β-D-4'-O-methylglucopyranosyl)-17-ethinylestr-17β-ol

Publications (2)

Publication Number Publication Date
PL426021A1 true PL426021A1 (en) 2020-01-02
PL238289B1 PL238289B1 (en) 2021-08-02

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL426021A PL238289B1 (en) 2018-06-22 2018-06-22 3-O-(β-D-4'-O-methylglucopyranosyl)-17-ethinylestr-17β-ol and method of preparation of 3-O-(β-D-4'-O-methylglucopyranosyl)-17-ethinylestr-17β-ol

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PL (1) PL238289B1 (en)

Also Published As

Publication number Publication date
PL238289B1 (en) 2021-08-02

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