PL435581A1 - Method for the production of 3'-hydroxy-5,7-dimethoxyflavone - Google Patents

Method for the production of 3'-hydroxy-5,7-dimethoxyflavone

Info

Publication number
PL435581A1
PL435581A1 PL435581A PL43558120A PL435581A1 PL 435581 A1 PL435581 A1 PL 435581A1 PL 435581 A PL435581 A PL 435581A PL 43558120 A PL43558120 A PL 43558120A PL 435581 A1 PL435581 A1 PL 435581A1
Authority
PL
Poland
Prior art keywords
dimethoxyflavone
hydroxy
production
regioselectively
hydroxylated
Prior art date
Application number
PL435581A
Other languages
Polish (pl)
Other versions
PL242340B1 (en
Inventor
Mateusz Łużny
Ewa Kozłowska
Edyta Kostrzewa-Susłow
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL435581A priority Critical patent/PL242340B1/en
Publication of PL435581A1 publication Critical patent/PL435581A1/en
Publication of PL242340B1 publication Critical patent/PL242340B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Wynalazek dotyczy sposobu wytwarzania 3'-hydroksy-5,7-dimetoksyflawono wzorze 2. Postępując zgodnie z wynalazkiem, w wyniku działania układu enzymatycznego zawartego w komórkach szczepu Isaria fumosorosea KCh J2, następuje regioselektywna hydroksylacja substratu. Uzyskany w ten sposób produkt wydziela się z wodnej kultury mikroorganizmu, znanym sposobem przez ekstrakcję rozpuszczalnikiem organicznym niemieszającym się z wodą (octan etylu).The invention relates to a process for the preparation of 3'-hydroxy-5,7-dimethoxyflavone of formula 2. By following the invention, the substrate is regioselectively hydroxylated by the action of the enzyme system contained in the cells of the Isaria fumosorosea KCh J2 strain. The product obtained in this way is separated from the aqueous culture of the microorganism by a known method by extraction with a water-immiscible organic solvent (ethyl acetate).

PL435581A 2020-10-05 2020-10-05 Method for the production of 3'-hydroxy-5,7-dimethoxyflavone PL242340B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL435581A PL242340B1 (en) 2020-10-05 2020-10-05 Method for the production of 3'-hydroxy-5,7-dimethoxyflavone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL435581A PL242340B1 (en) 2020-10-05 2020-10-05 Method for the production of 3'-hydroxy-5,7-dimethoxyflavone

Publications (2)

Publication Number Publication Date
PL435581A1 true PL435581A1 (en) 2022-04-11
PL242340B1 PL242340B1 (en) 2023-02-13

Family

ID=81076616

Family Applications (1)

Application Number Title Priority Date Filing Date
PL435581A PL242340B1 (en) 2020-10-05 2020-10-05 Method for the production of 3'-hydroxy-5,7-dimethoxyflavone

Country Status (1)

Country Link
PL (1) PL242340B1 (en)

Also Published As

Publication number Publication date
PL242340B1 (en) 2023-02-13

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