PL434960A1 - Sposób otrzymywania aprotyniny oraz produkt otrzymany tym sposobem - Google Patents
Sposób otrzymywania aprotyniny oraz produkt otrzymany tym sposobemInfo
- Publication number
- PL434960A1 PL434960A1 PL434960A PL43496020A PL434960A1 PL 434960 A1 PL434960 A1 PL 434960A1 PL 434960 A PL434960 A PL 434960A PL 43496020 A PL43496020 A PL 43496020A PL 434960 A1 PL434960 A1 PL 434960A1
- Authority
- PL
- Poland
- Prior art keywords
- aprotinin
- obtaining
- product obtained
- way
- ultrafiltration
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 108010039627 Aprotinin Proteins 0.000 title abstract 2
- 229960004405 aprotinin Drugs 0.000 title abstract 2
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 title abstract 2
- 238000000108 ultra-filtration Methods 0.000 abstract 3
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 238000000227 grinding Methods 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 238000001471 micro-filtration Methods 0.000 abstract 1
- 238000005185 salting out Methods 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Compounds Of Unknown Constitution (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
Abstract
Przedmiotem wynalazku jest sposób otrzymywania aprotyniny, szczególnie z płuc wołowych, zawierający kolejno etapy: rozdrabnianie, ekstrakcja, wirowanie, mikrofiltracja, chromatografia i, zatężanie i, wysalanie, filtracja, ultrafiltracja i, chromatografia ii, ultrafiltracja ii, zatężanie ii, ultrafiltracja III, liofilizacja, przemywanie. Przedmiotem wynalazku jest również produkt otrzymany tym sposobem.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL434960A PL434960A1 (pl) | 2020-08-13 | 2020-08-13 | Sposób otrzymywania aprotyniny oraz produkt otrzymany tym sposobem |
| PCT/PL2021/050058 WO2022035334A2 (en) | 2020-08-13 | 2021-08-11 | Method of obtaining aprotinin and product obtained thereby |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL434960A PL434960A1 (pl) | 2020-08-13 | 2020-08-13 | Sposób otrzymywania aprotyniny oraz produkt otrzymany tym sposobem |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL434960A1 true PL434960A1 (pl) | 2022-02-14 |
Family
ID=77989964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL434960A PL434960A1 (pl) | 2020-08-13 | 2020-08-13 | Sposób otrzymywania aprotyniny oraz produkt otrzymany tym sposobem |
Country Status (2)
| Country | Link |
|---|---|
| PL (1) | PL434960A1 (pl) |
| WO (1) | WO2022035334A2 (pl) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115259367B (zh) * | 2022-07-26 | 2023-11-17 | 上海净豚环保科技有限公司 | 一种食品废水用厌氧颗粒污泥的增殖培菌的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006042327A2 (en) * | 2004-10-12 | 2006-04-20 | Large Scale Biology Corporation | Plant-produced recombinant aprotinin and aprotinin variants |
-
2020
- 2020-08-13 PL PL434960A patent/PL434960A1/pl unknown
-
2021
- 2021-08-11 WO PCT/PL2021/050058 patent/WO2022035334A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022035334A3 (en) | 2022-03-31 |
| WO2022035334A2 (en) | 2022-02-17 |
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