PL435104A1 - Wielofunkcyjny, hydrożelowy materiał hybrydowy, sposób jego otrzymywania oraz zastosowanie w leczeniu ubytków kostnych - Google Patents
Wielofunkcyjny, hydrożelowy materiał hybrydowy, sposób jego otrzymywania oraz zastosowanie w leczeniu ubytków kostnychInfo
- Publication number
- PL435104A1 PL435104A1 PL435104A PL43510420A PL435104A1 PL 435104 A1 PL435104 A1 PL 435104A1 PL 435104 A PL435104 A PL 435104A PL 43510420 A PL43510420 A PL 43510420A PL 435104 A1 PL435104 A1 PL 435104A1
- Authority
- PL
- Poland
- Prior art keywords
- particles
- multifunctional
- hybrid material
- silica
- hydrogel hybrid
- Prior art date
Links
- 239000000017 hydrogel Substances 0.000 title abstract 3
- 239000000463 material Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 210000000988 bone and bone Anatomy 0.000 title 1
- 230000007547 defect Effects 0.000 title 1
- 239000002245 particle Substances 0.000 abstract 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 2
- 229920001661 Chitosan Polymers 0.000 abstract 2
- 102000008186 Collagen Human genes 0.000 abstract 2
- 108010035532 Collagen Proteins 0.000 abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 229910052586 apatite Inorganic materials 0.000 abstract 2
- 229920001436 collagen Polymers 0.000 abstract 2
- 229920002674 hyaluronan Polymers 0.000 abstract 2
- 229960003160 hyaluronic acid Drugs 0.000 abstract 2
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 abstract 1
- 239000004971 Cross linker Substances 0.000 abstract 1
- AZKVWQKMDGGDSV-BCMRRPTOSA-N Genipin Chemical compound COC(=O)C1=CO[C@@H](O)[C@@H]2C(CO)=CC[C@H]12 AZKVWQKMDGGDSV-BCMRRPTOSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 229940062527 alendronate Drugs 0.000 abstract 1
- DCSBSVSZJRSITC-UHFFFAOYSA-M alendronate sodium trihydrate Chemical compound O.O.O.[Na+].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O DCSBSVSZJRSITC-UHFFFAOYSA-M 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 229920001222 biopolymer Polymers 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- AZKVWQKMDGGDSV-UHFFFAOYSA-N genipin Natural products COC(=O)C1=COC(O)C2C(CO)=CCC12 AZKVWQKMDGGDSV-UHFFFAOYSA-N 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/432—Inhibitors, antagonists
- A61L2300/436—Inhibitors, antagonists of receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
Abstract
Wielofunkcyjny, hydrożelowy materiał hybrydowy, charakteryzujący się tym, że zawiera: a) matrycę biopolimerową zawierającą: kolagen, chitozan, kwas hialuronowy korzystnie modyfikowany, b) sfunkcjonalizowane grupami aminowymi cząstki krzemionkowo-apatytowe, c) substancję czynną w postaci alendronianu przyłączonego do cząstek krzemionkowo-apatytowych, d) substancję sieciującą. Przedmiotem zgłoszenia jest sposób wytwarzania wielofunkcyjnego, hydrożelowego materiału hybrydowego, charakteryzujący się tym, że obejmuje następujące etapy: a) cząstki krzemionkowe funkcjonalizuje się grupami aminowymi, b) cząstki otrzymane w etapie a) zawiesza się w wodnym roztworze SBF, korzystnie o stężeniu 1,5 M, otrzymując po 10 dniach inkubacji cząstki krzemionkowe pokryte fazą mineralną, c) do cząstek otrzymanych w etapie b) przyłącza się alendronian sodu, d) do wodnej zawiesiny cząstek z etapu c) dodaje się roztwór kolagenu, chitozanu i modyfikowanego lizyną kwasu hialuronowego, e) mieszaninę otrzymaną w etapie d) poddaje się reakcji sieciowania genipiną.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL435104A PL244455B1 (pl) | 2020-08-26 | 2020-08-26 | Wielofunkcyjny, hydrożelowy materiał hybrydowy, sposób jego otrzymywania oraz zastosowanie w leczeniu ubytków kostnych |
| EP21799130.6A EP4204028B1 (en) | 2020-08-26 | 2021-08-26 | Multifunctional, hydrogel hybrid material, the method of its preparation and the use in the treatment of bone losses |
| ES21799130T ES2995488T3 (en) | 2020-08-26 | 2021-08-26 | Multifunctional, hydrogel hybrid material, the method of its preparation and the use in the treatment of bone losses |
| US18/023,423 US20230310714A1 (en) | 2020-08-26 | 2021-08-26 | Multifunctional, hydrogel hybrid material, the method of its preparation and the use in the treatment of bone losses |
| PCT/PL2021/050060 WO2022045910A1 (en) | 2020-08-26 | 2021-08-26 | Multifunctional, hydrogel hybrid material, the method of its preparation and the use in the treatment of bone losses |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL435104A PL244455B1 (pl) | 2020-08-26 | 2020-08-26 | Wielofunkcyjny, hydrożelowy materiał hybrydowy, sposób jego otrzymywania oraz zastosowanie w leczeniu ubytków kostnych |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL435104A1 true PL435104A1 (pl) | 2022-02-28 |
| PL244455B1 PL244455B1 (pl) | 2024-01-29 |
Family
ID=78414057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL435104A PL244455B1 (pl) | 2020-08-26 | 2020-08-26 | Wielofunkcyjny, hydrożelowy materiał hybrydowy, sposób jego otrzymywania oraz zastosowanie w leczeniu ubytków kostnych |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20230310714A1 (pl) |
| EP (1) | EP4204028B1 (pl) |
| ES (1) | ES2995488T3 (pl) |
| PL (1) | PL244455B1 (pl) |
| WO (1) | WO2022045910A1 (pl) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL441996A1 (pl) * | 2022-08-11 | 2024-02-12 | Uniwersytet Jagielloński | Wielofunkcyjny, hydrożelowy materiał hybrydowy, w szczególności do stosowania w leczeniu ubytków kostnych oraz sposób jego otrzymywania |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL239179B1 (pl) | 2019-02-21 | 2021-11-08 | Univ Jagiellonski | Hydrożelowy materiał hybrydowy oraz sposób jego otrzymywania i zastosowanie |
-
2020
- 2020-08-26 PL PL435104A patent/PL244455B1/pl unknown
-
2021
- 2021-08-26 EP EP21799130.6A patent/EP4204028B1/en active Active
- 2021-08-26 WO PCT/PL2021/050060 patent/WO2022045910A1/en not_active Ceased
- 2021-08-26 US US18/023,423 patent/US20230310714A1/en active Pending
- 2021-08-26 ES ES21799130T patent/ES2995488T3/es active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL441996A1 (pl) * | 2022-08-11 | 2024-02-12 | Uniwersytet Jagielloński | Wielofunkcyjny, hydrożelowy materiał hybrydowy, w szczególności do stosowania w leczeniu ubytków kostnych oraz sposób jego otrzymywania |
| EP4324492A1 (en) * | 2022-08-11 | 2024-02-21 | Uniwersytet Jagiellonski | Multifunctional, hydrogel hybrid material, method of its preparation and use in the treatment of bone losses |
| PL247558B1 (pl) * | 2022-08-11 | 2025-07-28 | Univ Jagiellonski | Wielofunkcyjny, hydrożelowy materiał hybrydowy, w szczególności do stosowania w leczeniu ubytków kostnych oraz sposób jego otrzymywania |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2995488T3 (en) | 2025-02-10 |
| US20230310714A1 (en) | 2023-10-05 |
| EP4204028B1 (en) | 2024-10-09 |
| EP4204028A1 (en) | 2023-07-05 |
| WO2022045910A1 (en) | 2022-03-03 |
| PL244455B1 (pl) | 2024-01-29 |
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