PL437519A1 - Mixture of naphthoquinone and silver and use of the mixture as antimicrobial agent for the control of Pseudomonas aeruginosa - Google Patents
Mixture of naphthoquinone and silver and use of the mixture as antimicrobial agent for the control of Pseudomonas aeruginosaInfo
- Publication number
- PL437519A1 PL437519A1 PL437519A PL43751921A PL437519A1 PL 437519 A1 PL437519 A1 PL 437519A1 PL 437519 A PL437519 A PL 437519A PL 43751921 A PL43751921 A PL 43751921A PL 437519 A1 PL437519 A1 PL 437519A1
- Authority
- PL
- Poland
- Prior art keywords
- mixture
- naphthoquinone
- antimicrobial agent
- pseudomonas aeruginosa
- menadione
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 241000589517 Pseudomonas aeruginosa Species 0.000 title abstract 2
- 239000004599 antimicrobial Substances 0.000 title abstract 2
- 229930192627 Naphthoquinone Natural products 0.000 title 1
- 150000002791 naphthoquinones Chemical class 0.000 title 1
- 229910052709 silver Inorganic materials 0.000 title 1
- 239000004332 silver Substances 0.000 title 1
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 abstract 10
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 abstract 3
- 235000012711 vitamin K3 Nutrition 0.000 abstract 3
- 239000011652 vitamin K3 Substances 0.000 abstract 3
- 229940041603 vitamin k 3 Drugs 0.000 abstract 3
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Wynalazek dotyczy właściwości bakteriobójczych mieszaniny nanocząstek srebra oraz 2-metylo-1,4-naftochinonu, zwanego menadionem wobec naturalnie opornej pałeczki ropy błękitnej, tj. Pseudomonas aeruginosa. Wynalazek dotyczy również medycznego zastosowania mieszaniny do zwalczania P. aeruginosa oraz zastosowania tej mieszaniny jako środka o działaniu przeciwbakteryjnym do stosowania zewnętrznie, tj. na skórę lub rany. Mieszanina według wynalazku zawiera nanocząstki srebra oraz 2-metylo-1,4-naftochinon, zwany menadionem. Wykazany mechanizm oddziaływań nanocząstek srebra i menadionu stanowi zjawisko o wysokim potencjale do zwalczania jednego z najgroźniejszych patogenów bakteryjnych człowieka — P. aeruginosa.The invention relates to the bactericidal properties of a mixture of silver nanoparticles and 2-methyl-1,4-naphthoquinone, known as menadione, against the naturally resistant blue oil rod, i.e. Pseudomonas aeruginosa. The invention also relates to the medical use of the mixture for controlling P. aeruginosa and the use of the mixture as an antimicrobial agent for topical application, i.e. to the skin or wounds. The mixture according to the invention contains silver nanoparticles and 2-methyl-1,4-naphthoquinone, called menadione. The demonstrated mechanism of the interaction of silver nanoparticles and menadione is a phenomenon with a high potential to combat one of the most dangerous human bacterial pathogens - P. aeruginosa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL437519A PL245017B1 (en) | 2021-04-08 | 2021-04-08 | Mixture of naphthoquinone and silver and use of the mixture as antimicrobial agent for the control of Pseudomonas aeruginosa |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL437519A PL245017B1 (en) | 2021-04-08 | 2021-04-08 | Mixture of naphthoquinone and silver and use of the mixture as antimicrobial agent for the control of Pseudomonas aeruginosa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL437519A1 true PL437519A1 (en) | 2022-04-11 |
| PL245017B1 PL245017B1 (en) | 2024-04-22 |
Family
ID=81076656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL437519A PL245017B1 (en) | 2021-04-08 | 2021-04-08 | Mixture of naphthoquinone and silver and use of the mixture as antimicrobial agent for the control of Pseudomonas aeruginosa |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL245017B1 (en) |
-
2021
- 2021-04-08 PL PL437519A patent/PL245017B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL245017B1 (en) | 2024-04-22 |
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