PL438501A1 - Kompozycja w postaci nanoemulsji na bazie oleju roślinnego, kompozycja wielofazowa oraz sposób wytwarzania tych kompozycji - Google Patents

Kompozycja w postaci nanoemulsji na bazie oleju roślinnego, kompozycja wielofazowa oraz sposób wytwarzania tych kompozycji Download PDF

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Publication number
PL438501A1
PL438501A1 PL438501A PL43850121A PL438501A1 PL 438501 A1 PL438501 A1 PL 438501A1 PL 438501 A PL438501 A PL 438501A PL 43850121 A PL43850121 A PL 43850121A PL 438501 A1 PL438501 A1 PL 438501A1
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PL
Poland
Prior art keywords
mass
parts
composition
vegetable oil
phase
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PL438501A
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English (en)
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PL246054B1 (pl
Inventor
Katarzyna Małolepsza-Jarmołowska
Michał Smoleński
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Univ Medyczny Im Piastow Slaskich We Wroclawiu
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Application filed by Univ Medyczny Im Piastow Slaskich We Wroclawiu filed Critical Univ Medyczny Im Piastow Slaskich We Wroclawiu
Priority to PL438501A priority Critical patent/PL246054B1/pl
Priority to PCT/PL2022/000039 priority patent/WO2023287309A1/en
Priority to EP22783381.1A priority patent/EP4370096A1/en
Publication of PL438501A1 publication Critical patent/PL438501A1/pl
Publication of PL246054B1 publication Critical patent/PL246054B1/pl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Edible Oils And Fats (AREA)

Abstract

Pierwszym przedmiotem wynalazku jest kompozycja w postaci nanoemulsji na bazie oleju roślinnego, charakteryzująca się tym, że zawiera olej roślinny, który stanowi olej rzepakowy, w ilości od 10 do 60 części masowych oleju rzepakowego, od 12 do 20 części masowych poloksameru 188, od 40 do 60 części masowych wody oczyszczonej, od 1 do 12 części masowych Spanu 80, od 5 do 20 części masowych poliolu, od 0,10 do 0,50 części masowych kwasu mlekowego, od 0,5 do 5,0 części masowych klotrimazolu, przy czym krople fazy olejowej mają średnicę hydrodynamiczną od 50 nm do 70 nm. Drugim przedmiotem wynalazku jest kompozycja wielofazowa na bazie nanoemulsji oleju roślinnego, charakteryzująca się tym, że zawiera fazę polisacharydową w ilości od 10 do 50 części masowych i nanoemulsję wg pierwszego przedmiotu wynalazku w ilości od 50 do 90 części masowych, przy czym kompozycja wielofazowa ma postać nanoemulżelu, przy czym kompozycja wielofazowa ma lepkość dynamiczną od 220 mPa•s do 580 mPa•s. Wynalazek obejmuje także sposoby otrzymywania rzeczonych kompozycji.

Description

PL 438501 A1 2/25PL 438501 A1 3/25PL 438501 A1 4/25PL 438501 A1 /25PL 438501 A1 6/25PL 438501 A1 7/25PL 438501 A1 8/25PL 438501 A1 9/25PL 438501 A1 /25PL 438501 A1 11/25PL 438501 A1 12/25PL 438501 A1 13/25PL 438501 A1 14/25PL 438501 A1 /25PL 438501 A1 16/25PL 438501 A1 17/25PL 438501 A1 18/25PL 438501 A1 19/25PL 438501 A1 /25PL 438501 A1 21/25PL 438501 A1 22/25PL 438501 A1 23/25PL 438501 A1 24/25PL 438501 A1 /25 PL

Claims (1)

1.
PL438501A 2021-07-16 2021-07-16 Kompozycja farmaceutyczna w postaci nanoemulsji na bazie oleju roślinnego, kompozycja farmaceutyczna wielofazowa oraz sposób wytwarzania tych kompozycji farmaceutycznych PL246054B1 (pl)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PL438501A PL246054B1 (pl) 2021-07-16 2021-07-16 Kompozycja farmaceutyczna w postaci nanoemulsji na bazie oleju roślinnego, kompozycja farmaceutyczna wielofazowa oraz sposób wytwarzania tych kompozycji farmaceutycznych
PCT/PL2022/000039 WO2023287309A1 (en) 2021-07-16 2022-07-15 Pharmaceutical composition in the form of vegetable oil-based nanoemulsion, multiphase composition and method of preparation of these compositions
EP22783381.1A EP4370096A1 (en) 2021-07-16 2022-07-15 Pharmaceutical composition in the form of vegetable oil-based nanoemulsion, multiphase composition and method of preparation of these compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL438501A PL246054B1 (pl) 2021-07-16 2021-07-16 Kompozycja farmaceutyczna w postaci nanoemulsji na bazie oleju roślinnego, kompozycja farmaceutyczna wielofazowa oraz sposób wytwarzania tych kompozycji farmaceutycznych

Publications (2)

Publication Number Publication Date
PL438501A1 true PL438501A1 (pl) 2023-01-23
PL246054B1 PL246054B1 (pl) 2024-11-25

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ID=83546936

Family Applications (1)

Application Number Title Priority Date Filing Date
PL438501A PL246054B1 (pl) 2021-07-16 2021-07-16 Kompozycja farmaceutyczna w postaci nanoemulsji na bazie oleju roślinnego, kompozycja farmaceutyczna wielofazowa oraz sposób wytwarzania tych kompozycji farmaceutycznych

Country Status (3)

Country Link
EP (1) EP4370096A1 (pl)
PL (1) PL246054B1 (pl)
WO (1) WO2023287309A1 (pl)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2094688B1 (es) * 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
KR20040028336A (ko) * 2002-09-30 2004-04-03 김종국 신규한 질내 투여용 항균 온도감응성 겔 조성물
CN1931163A (zh) * 2006-09-20 2007-03-21 西北农林科技大学 一种克霉唑纳米乳液药物及其制备方法
PL210178B1 (pl) * 2007-06-15 2011-12-30 Politechnika Wroclawska Sposób wytwarzania mikroemulsji stabilizowanej surfaktantami
JP2011505235A (ja) * 2007-11-28 2011-02-24 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼイション ナノエマルション
DE102008034944B4 (de) * 2008-07-26 2017-03-16 Arivine Pharma Ag Mikroemulsion
DE102014203152A1 (de) * 2014-02-21 2015-08-27 Ursapharm Arzneimittel Gmbh Mikro- oder Nanoemulsion zur ophthalmologischen Anwendung
CN110664733A (zh) * 2019-10-09 2020-01-10 华欧研创生物科技(深圳)有限公司 用于女性阴道护理的玻尿酸纳米乳凝胶剂

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Publication number Publication date
EP4370096A1 (en) 2024-05-22
WO2023287309A1 (en) 2023-01-19
PL246054B1 (pl) 2024-11-25

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