PL439100A1 - Method for producing 4'-hydroxyflavanone - Google Patents

Method for producing 4'-hydroxyflavanone

Info

Publication number
PL439100A1
PL439100A1 PL439100A PL43910021A PL439100A1 PL 439100 A1 PL439100 A1 PL 439100A1 PL 439100 A PL439100 A PL 439100A PL 43910021 A PL43910021 A PL 43910021A PL 439100 A1 PL439100 A1 PL 439100A1
Authority
PL
Poland
Prior art keywords
hydroxyflavanone
hours
formula
organic solvent
water
Prior art date
Application number
PL439100A
Other languages
Polish (pl)
Other versions
PL244301B1 (en
Inventor
Agnieszka Krawczyk-Łebek
Edyta Kostrzewa-Susłow
Monika Dymarska
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL439100A priority Critical patent/PL244301B1/en
Publication of PL439100A1 publication Critical patent/PL439100A1/en
Publication of PL244301B1 publication Critical patent/PL244301B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób wytwarzania 4'-hydroksyflawanonu, który polega na tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria farinosa KCH J2.6, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 4'-metyloflawanon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie, przy czym 4'-hydroksyflawanon o wzorze 2 znajduje się we frakcji o pośredniej polarności w trzecim paśmie od linii startu.The subject of the application is a method for the production of 4'-hydroxyflavanone, which consists in introducing the Isaria farinosa KCH J2.6 strain into a substrate suitable for filamentous fungi, then, after at least 72 hours, a substrate is introduced into the culture, which is 4'- methylflavanone of the formula I, dissolved in a water-miscible organic solvent, transformation is carried out at a temperature of 20 to 30 degrees Celsius, with continuous shaking, for at least 96 hours, after which the product is extracted with a water-immiscible organic solvent and purified by chromatography, wherein the 4'-hydroxyflavanone of formula 2 is in the fraction of intermediate polarity in the third band from the starting line.

PL439100A 2021-09-30 2021-09-30 Method for producing 4'-hydroxyflavanone PL244301B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL439100A PL244301B1 (en) 2021-09-30 2021-09-30 Method for producing 4'-hydroxyflavanone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL439100A PL244301B1 (en) 2021-09-30 2021-09-30 Method for producing 4'-hydroxyflavanone

Publications (2)

Publication Number Publication Date
PL439100A1 true PL439100A1 (en) 2023-04-03
PL244301B1 PL244301B1 (en) 2024-01-08

Family

ID=85783973

Family Applications (1)

Application Number Title Priority Date Filing Date
PL439100A PL244301B1 (en) 2021-09-30 2021-09-30 Method for producing 4'-hydroxyflavanone

Country Status (1)

Country Link
PL (1) PL244301B1 (en)

Also Published As

Publication number Publication date
PL244301B1 (en) 2024-01-08

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