PL439093A1 - Method for preparing 4'-hydroxymethylflavone - Google Patents

Method for preparing 4'-hydroxymethylflavone

Info

Publication number
PL439093A1
PL439093A1 PL439093A PL43909321A PL439093A1 PL 439093 A1 PL439093 A1 PL 439093A1 PL 439093 A PL439093 A PL 439093A PL 43909321 A PL43909321 A PL 43909321A PL 439093 A1 PL439093 A1 PL 439093A1
Authority
PL
Poland
Prior art keywords
hydroxymethylflavone
hours
formula
organic solvent
water
Prior art date
Application number
PL439093A
Other languages
Polish (pl)
Other versions
PL244524B1 (en
Inventor
Agnieszka Krawczyk-Łebek
Edyta Kostrzewa-Susłow
Monika Dymarska
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL439093A priority Critical patent/PL244524B1/en
Publication of PL439093A1 publication Critical patent/PL439093A1/en
Publication of PL244524B1 publication Critical patent/PL244524B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest sposób wytwarzania 4'-hydroksymetyloflawonu, polegający na tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria fumosorosea KCH J2, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 4'-metyloflawon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie, przy czym 4'-hydroksymetyloflawon o wzorze 2 znajduje się we frakcji o pośredniej polarności, w szóstym paśmie od linii startu.The subject of the application is a method of producing 4'-hydroxymethylflavone, in which the strain Isaria fumosorosea KCH J2 is introduced into the substrate suitable for filamentous fungi, and then, after at least 72 hours, the substrate is introduced into the culture, which is 4'-methylflavone of the formula 1, dissolved in a water-miscible organic solvent, transformation is carried out at a temperature of 20 to 30 degrees Celsius with continuous shaking for at least 96 hours, after which the product is extracted with a water-miscible organic solvent and purified by chromatography, whereby 4 '-hydroxymethylflavone of the formula 2 is in the fraction of intermediate polarity, in the sixth band from the starting line.

PL439093A 2021-09-30 2021-09-30 Method of producing 4'-hydroxymethylflavone PL244524B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL439093A PL244524B1 (en) 2021-09-30 2021-09-30 Method of producing 4'-hydroxymethylflavone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL439093A PL244524B1 (en) 2021-09-30 2021-09-30 Method of producing 4'-hydroxymethylflavone

Publications (2)

Publication Number Publication Date
PL439093A1 true PL439093A1 (en) 2023-04-03
PL244524B1 PL244524B1 (en) 2024-02-05

Family

ID=85783999

Family Applications (1)

Application Number Title Priority Date Filing Date
PL439093A PL244524B1 (en) 2021-09-30 2021-09-30 Method of producing 4'-hydroxymethylflavone

Country Status (1)

Country Link
PL (1) PL244524B1 (en)

Also Published As

Publication number Publication date
PL244524B1 (en) 2024-02-05

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