PL441127A1 - Koniugaty 5-fluorouracylu i dichlorooctanu 2-hydroksyetylu oraz sposób ich otrzymywania - Google Patents
Koniugaty 5-fluorouracylu i dichlorooctanu 2-hydroksyetylu oraz sposób ich otrzymywaniaInfo
- Publication number
- PL441127A1 PL441127A1 PL441127A PL44112722A PL441127A1 PL 441127 A1 PL441127 A1 PL 441127A1 PL 441127 A PL441127 A PL 441127A PL 44112722 A PL44112722 A PL 44112722A PL 441127 A1 PL441127 A1 PL 441127A1
- Authority
- PL
- Poland
- Prior art keywords
- compound
- formula
- dichloroacetate
- fluorouracil
- conjugates
- Prior art date
Links
- YLTRHKHSEKYGFP-UHFFFAOYSA-N 2-hydroxyethyl 2,2-dichloroacetate Chemical compound OCCOC(=O)C(Cl)Cl YLTRHKHSEKYGFP-UHFFFAOYSA-N 0.000 title abstract 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002949 fluorouracil Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 6
- 239000000010 aprotic solvent Substances 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 230000008878 coupling Effects 0.000 abstract 2
- 238000010168 coupling process Methods 0.000 abstract 2
- 238000005859 coupling reaction Methods 0.000 abstract 2
- 238000004090 dissolution Methods 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 239000003586 protic polar solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem zgłoszenia są koniugaty 5-fluorouracylu i dichlorooctanu 2-hydroksyetylu o wzorze ogólnym 1, w którym n oznacza przynajmniej jedną grupę metylenową, korzystnie n oznacza 1-5 grup metylenowych oraz sposób ich otrzymywania, który polega na reakcji związku o wzorze 2 ze związkiem o wzorze 3 w obecności odczynnika sprzęgającego w rozpuszczalniku aprotonowym, w wyniku której otrzymuje się związek o wzorze 4, który po rozpuszczeniu w rozpuszczalniku protonowym przekształcany jest podczas katalitycznego uwodornienia w związek o wzorze 5, który po rozpuszczeniu w rozpuszczalniku aprotonowym w reakcji ze związkiem o wzorze 6 w obecności odczynnika sprzęgającego daje związek o wzorze ogólnym 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL441127A PL245285B1 (pl) | 2022-05-09 | 2022-05-09 | Koniugaty 5-fluorouracylu i dichlorooctanu 2-hydroksyetylu oraz sposób ich otrzymywania |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL441127A PL245285B1 (pl) | 2022-05-09 | 2022-05-09 | Koniugaty 5-fluorouracylu i dichlorooctanu 2-hydroksyetylu oraz sposób ich otrzymywania |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL441127A1 true PL441127A1 (pl) | 2023-11-13 |
| PL245285B1 PL245285B1 (pl) | 2024-06-17 |
Family
ID=88789774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL441127A PL245285B1 (pl) | 2022-05-09 | 2022-05-09 | Koniugaty 5-fluorouracylu i dichlorooctanu 2-hydroksyetylu oraz sposób ich otrzymywania |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL245285B1 (pl) |
-
2022
- 2022-05-09 PL PL441127A patent/PL245285B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL245285B1 (pl) | 2024-06-17 |
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