PL441126A1 - Koniugaty 5-fluorouracylu i kwasu dichloroctowego oraz sposób ich otrzymywania - Google Patents

Koniugaty 5-fluorouracylu i kwasu dichloroctowego oraz sposób ich otrzymywania

Info

Publication number
PL441126A1
PL441126A1 PL441126A PL44112622A PL441126A1 PL 441126 A1 PL441126 A1 PL 441126A1 PL 441126 A PL441126 A PL 441126A PL 44112622 A PL44112622 A PL 44112622A PL 441126 A1 PL441126 A1 PL 441126A1
Authority
PL
Poland
Prior art keywords
compound
formula
fluorouracil
conjugates
preparation
Prior art date
Application number
PL441126A
Other languages
English (en)
Other versions
PL245284B1 (pl
Inventor
Ewa Mironiuk-Puchalska
Mariola Koszytkowska-Stawińska
Original Assignee
Politechnika Warszawska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Politechnika Warszawska filed Critical Politechnika Warszawska
Priority to PL441126A priority Critical patent/PL245284B1/pl
Publication of PL441126A1 publication Critical patent/PL441126A1/pl
Publication of PL245284B1 publication Critical patent/PL245284B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia są koniugaty 5-fluorouracylu i kwasu dichlorooctowego o wzorze ogólnym 1, w którym n oznacza przynajmniej jedną grupę metylenową, korzystnie n oznacza 1-5 grup metylenowych oraz sposób ich otrzymywania, który polega na reakcji związku o wzorze 2 ze związkiem o wzorze 3 prowadzonej wobec aminy alifatycznej w rozpuszczalniku aprotonowym, w wyniku której otrzymuje się związek o wzorze 4, który po rozpuszczeniu w rozpuszczalniku aprotonowym w reakcji ze związkiem o wzorze 5, prowadzonej w obecności jodku sodu daje związek o wzorze ogólnym 1.
PL441126A 2022-05-09 2022-05-09 Koniugaty 5-fluorouracylu i kwasu dichloroctowego oraz sposób ich otrzymywania PL245284B1 (pl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL441126A PL245284B1 (pl) 2022-05-09 2022-05-09 Koniugaty 5-fluorouracylu i kwasu dichloroctowego oraz sposób ich otrzymywania

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL441126A PL245284B1 (pl) 2022-05-09 2022-05-09 Koniugaty 5-fluorouracylu i kwasu dichloroctowego oraz sposób ich otrzymywania

Publications (2)

Publication Number Publication Date
PL441126A1 true PL441126A1 (pl) 2023-11-13
PL245284B1 PL245284B1 (pl) 2024-06-17

Family

ID=88789791

Family Applications (1)

Application Number Title Priority Date Filing Date
PL441126A PL245284B1 (pl) 2022-05-09 2022-05-09 Koniugaty 5-fluorouracylu i kwasu dichloroctowego oraz sposób ich otrzymywania

Country Status (1)

Country Link
PL (1) PL245284B1 (pl)

Also Published As

Publication number Publication date
PL245284B1 (pl) 2024-06-17

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