PT100511A - Uso de neurotrofina-4, processo de diagnostico baseado na expressao da mesma e producao de neurotrofina-4, e conjunto de diagnostico - Google Patents

Uso de neurotrofina-4, processo de diagnostico baseado na expressao da mesma e producao de neurotrofina-4, e conjunto de diagnostico Download PDF

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Publication number: PT100511A
Authority: PT; Portugal
Prior art keywords: arg; ser; thr; seq; gly
Prior art date: 1991-05-21

Application number

PT100511A

Other languages

English (en)

Portuguese (pt)

Inventor

Nancy Ip

George D Yancopoulos

Original Assignee

Regeneron Pharma

Finn Hallbook

Carlos Fernando Ibanez Moliner

Hakan Bengt Persson

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-21

Filing date

1992-05-21

Publication date

1993-09-30

1992-05-21 Application filed by Regeneron Pharma, Finn Hallbook, Carlos Fernando Ibanez Moliner, Hakan Bengt Persson filed Critical Regeneron Pharma

1993-09-30 Publication of PT100511A publication Critical patent/PT100511A/pt

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229910000033 sodium borohydride Inorganic materials 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
210000001913 submandibular gland Anatomy 0.000 description 1
239000000758 substrate Substances 0.000 description 1
FRGKKTITADJNOE-UHFFFAOYSA-N sulfanyloxyethane Chemical compound CCOS FRGKKTITADJNOE-UHFFFAOYSA-N 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
230000001360 synchronised effect Effects 0.000 description 1
230000002381 testicular Effects 0.000 description 1
229960003604 testosterone Drugs 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
238000010361 transduction Methods 0.000 description 1
230000026683 transduction Effects 0.000 description 1
230000001131 transforming effect Effects 0.000 description 1
230000007704 transition Effects 0.000 description 1
230000032258 transport Effects 0.000 description 1
FQZJYWMRQDKBQN-UHFFFAOYSA-N tricaine methanesulfonate Chemical compound CS([O-])(=O)=O.CCOC(=O)C1=CC=CC([NH3+])=C1 FQZJYWMRQDKBQN-UHFFFAOYSA-N 0.000 description 1
229940013180 tricaine methanesulfonate Drugs 0.000 description 1
229960001322 trypsin Drugs 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
102000003390 tumor necrosis factor Human genes 0.000 description 1
ZHSGGJXRNHWHRS-VIDYELAYSA-N tunicamycin Chemical compound O([C@H]1[C@@H]([C@H]([C@@H](O)[C@@H](CC(O)[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C(NC(=O)C=C2)=O)O)O1)O)NC(=O)/C=C/CC(C)C)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O ZHSGGJXRNHWHRS-VIDYELAYSA-N 0.000 description 1
MEYZYGMYMLNUHJ-UHFFFAOYSA-N tunicamycin Natural products CC(C)CCCCCCCCCC=CC(=O)NC1C(O)C(O)C(CC(O)C2OC(C(O)C2O)N3C=CC(=O)NC3=O)OC1OC4OC(CO)C(O)C(O)C4NC(=O)C MEYZYGMYMLNUHJ-UHFFFAOYSA-N 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
108010051110 tyrosyl-lysine Proteins 0.000 description 1
239000004474 valine Substances 0.000 description 1
108010015385 valyl-prolyl-proline Proteins 0.000 description 1
238000012795 verification Methods 0.000 description 1
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
229960004528 vincristine Drugs 0.000 description 1
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
108010027345 wheylin-1 peptide Proteins 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Neurology (AREA)
Immunology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Toys (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

PT100511A 1991-05-21 1992-05-21 Uso de neurotrofina-4, processo de diagnostico baseado na expressao da mesma e producao de neurotrofina-4, e conjunto de diagnostico PT100511A (pt)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date
US70345091A	1991-05-21	1991-05-21
US72925391A	1991-07-12	1991-07-12
US73442291A	1991-07-23	1991-07-23
US75135691A	1991-08-28	1991-08-28
US76267491A	1991-09-20	1991-09-20
US79192491A	1991-11-14	1991-11-14

Publications (1)

Publication Number	Publication Date
PT100511A true PT100511A (pt)	1993-09-30

Family

ID=27560239

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT100511A PT100511A (pt)	1991-05-21	1992-05-21	Uso de neurotrofina-4, processo de diagnostico baseado na expressao da mesma e producao de neurotrofina-4, e conjunto de diagnostico

Country Status (8)

Country	Link
EP (1)	EP0587806A4 (fr)
JP (1)	JPH08510987A (fr)
AU (1)	AU674659B2 (fr)
CA (1)	CA2109598A1 (fr)
IE (1)	IE921636A1 (fr)
NZ (1)	NZ242813A (fr)
PT (1)	PT100511A (fr)
WO (1)	WO1992020365A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE140966T1 (de) *	1990-09-25	1996-08-15	Genentech Inc	Neuer neurotropischer faktor
ATE154389T1 (de)	1991-02-18	1997-06-15	Takeda Chemical Industries Ltd	Verfahren zur herstellung von menschlichem ngf-2
WO1993025684A1 (fr) *	1992-06-12	1993-12-23	Regeneron Pharmaceuticals, Inc.	Procedes therapeutique et diagnostique bases sur l'expression de la neurotrophine-4
FI991197A0 (fi) *	1999-05-27	1999-05-27	Mart Saarma	Neurotrooppiset tekijät lantionalueen ääreishermoston toimintahäiriön hoitamisessa

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5169764A (en) *	1990-08-08	1992-12-08	Regeneron Pharmaceuticals, Inc.	Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras
ATE140966T1 (de) *	1990-09-25	1996-08-15	Genentech Inc	Neuer neurotropischer faktor
IL101661A (en) *	1991-04-23	1998-02-08	Regeneron Pharma	Method for detecting, identifying or measuring agents having neurotrophin activity

1992
- 1992-05-20 CA CA002109598A patent/CA2109598A1/fr not_active Abandoned
- 1992-05-20 NZ NZ242813A patent/NZ242813A/en unknown
- 1992-05-20 AU AU23021/92A patent/AU674659B2/en not_active Ceased
- 1992-05-20 EP EP92914704A patent/EP0587806A4/fr not_active Withdrawn
- 1992-05-20 JP JP5500288A patent/JPH08510987A/ja active Pending
- 1992-05-20 WO PCT/US1992/004266 patent/WO1992020365A1/fr not_active Ceased
- 1992-05-21 PT PT100511A patent/PT100511A/pt not_active Application Discontinuation
- 1992-07-01 IE IE163692A patent/IE921636A1/en unknown

Also Published As

Publication number	Publication date
JPH08510987A (ja)	1996-11-19
NZ242813A (en)	1996-09-25
CA2109598A1 (fr)	1992-11-26
AU2302192A (en)	1992-12-30
WO1992020365A1 (fr)	1992-11-26
IE921636A1 (en)	1992-12-02
EP0587806A1 (fr)	1994-03-23
EP0587806A4 (fr)	1995-04-26
AU674659B2 (en)	1997-01-09

Legal Events

Date	Code	Title	Description
1993-09-30	BB1A	Laying open of patent application	Effective date: 19930317
1999-07-30	FC3A	Refusal	Effective date: 19990407

Publication	Publication Date	Title
US5229500A (en)	1993-07-20	Brain derived neurotrophic factor
CA2040437C (fr)	2002-10-22	Neurotrophine-3, nouveau facteur neurotrophique lie au facteur de croissance du tissu nerveux et au facteur neurotrophique derive du cerveau
US5180820A (en)	1993-01-19	Brain-derived neurotrophic factor
FI117556B (fi)	2006-11-30	Yhdistelmä-DNA-menetelmä hermoston tukikudosperäisen neurotrofisen tekijän tuottamiseksi
Burke et al.	1994	Loss of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus: rescue by neurotrophins
HK1006578B (en)	1999-03-05	Brain derived neurotrophic factor
EP0542892A1 (fr)	1993-05-26	Facteurs neurotrophiques chimeriques
HK1006579B (en)	1999-03-05	Neurotrophin-3, a novel neurotrophic factor related to nerve growth factor and brain derived neurotrophic factor
AU4535993A (en)	1994-01-04	Therapeutic and diagnostic methods based on neurotrophin-4 expression
US20020164702A1 (en)	2002-11-07	Novel tyrosine kinase receptors and ligands
PT100511A (pt)	1993-09-30	Uso de neurotrofina-4, processo de diagnostico baseado na expressao da mesma e producao de neurotrofina-4, e conjunto de diagnostico
WO1993001300A1 (fr)	1993-01-21	Methodes de traitement de maladies des neurones moteurs utilisant des elements de la famille des molecules bdnf/nt-3/ngf
Rushlow et al.	1999	Characterization of CArG-binding protein A initially identified by differential display
US6933276B1 (en)	2005-08-23	Methods of treating peripheral neuropathies using neurotrophin-3
PT101064A (pt)	1994-02-28	Proteinas e peptidos prepro quimericos, moleculas de acido nucleico que os codificam, e processo de producao de uma neurotrofina
NZ270485A (en)	1996-09-25	Diagnosis of motor neuron disease using neurotrophin-4 (nt-4) and methods for measuring its activity
WO1994009765A1 (fr)	1994-05-11	Interactions fonctionnelles entre le s-100b glial et les neurones serotoninergiques du systeme nerveux central
Snyder	1996	Expression of themRNA encoding VGF, a neural-specific peptide precursor, in the developing and adult rat central nervous systems, and its modulation in response to changes in neuronal electrical activity, seizure, and lesion
Bishop	1996	Regulatory mechanisms involved in the expression of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor