PT100710B - Processo para a preparacao de tiazolidina-2,4-diona quirais hipoglicemicas e seus intermediarios - Google Patents

Processo para a preparacao de tiazolidina-2,4-diona quirais hipoglicemicas e seus intermediarios Download PDF

Info

Publication number
PT100710B
PT100710B PT100710A PT10071092A PT100710B PT 100710 B PT100710 B PT 100710B PT 100710 A PT100710 A PT 100710A PT 10071092 A PT10071092 A PT 10071092A PT 100710 B PT100710 B PT 100710B
Authority
PT
Portugal
Prior art keywords
borane
methyl
process according
formula
phenyl
Prior art date
Application number
PT100710A
Other languages
English (en)
Portuguese (pt)
Other versions
PT100710A (pt
Inventor
George J Quallich
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PT100710A publication Critical patent/PT100710A/pt
Publication of PT100710B publication Critical patent/PT100710B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT100710A 1991-07-22 1992-07-20 Processo para a preparacao de tiazolidina-2,4-diona quirais hipoglicemicas e seus intermediarios PT100710B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73356491A 1991-07-22 1991-07-22

Publications (2)

Publication Number Publication Date
PT100710A PT100710A (pt) 1993-09-30
PT100710B true PT100710B (pt) 1999-07-30

Family

ID=24948157

Family Applications (1)

Application Number Title Priority Date Filing Date
PT100710A PT100710B (pt) 1991-07-22 1992-07-20 Processo para a preparacao de tiazolidina-2,4-diona quirais hipoglicemicas e seus intermediarios

Country Status (21)

Country Link
US (1) US5512689A (da)
EP (1) EP0595868B1 (da)
JP (1) JP2671962B2 (da)
AT (1) ATE173728T1 (da)
AU (1) AU660701B2 (da)
CA (1) CA2111445C (da)
DE (1) DE69227689T2 (da)
DK (1) DK0595868T3 (da)
ES (1) ES2123562T3 (da)
FI (1) FI940306A7 (da)
HU (1) HUT70412A (da)
IE (1) IE922359A1 (da)
IL (1) IL102574A (da)
MX (1) MX9204278A (da)
MY (1) MY131277A (da)
NO (1) NO940227D0 (da)
NZ (1) NZ243651A (da)
PT (1) PT100710B (da)
TW (1) TW199891B (da)
WO (1) WO1993002060A1 (da)
ZA (1) ZA925469B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0641331A1 (en) * 1991-07-22 1995-03-08 Pfizer Inc. Chiral intermediates for the preparation of antidiabetics thiazoles
FR2699172B1 (fr) * 1992-12-11 1995-01-20 Adir Nouveaux dérivés de 4-méthyl-1,3-oxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
TW416958B (en) * 1993-05-14 2001-01-01 Pfizer Enantioselective oxazaborolidine catalysts
BR0013671A (pt) 1999-08-31 2003-06-10 Maxia Pharmaceuticals Inc Derivados heterocìclicos para o tratamento do diabetes e outras doenças
WO2002072009A2 (en) 2001-03-07 2002-09-19 Maxia Pharmaceuticals, Inc. Heterocyclic derivatives for the treatment of cancer and other proliferative diseases
JP2004523571A (ja) * 2001-03-08 2004-08-05 マキシア・ファーマシューティカルズ・インコーポレイテッド Ｒｘｒ活性化分子
CA2340824A1 (en) * 2001-03-14 2002-09-14 Ibm Canada Limited-Ibm Canada Limitee Method and system for application behavior analysis
JP2005500379A (ja) * 2001-08-17 2005-01-06 インサイト サンディエゴ インコーポレーテッド 異脂肪血症および高コレステロール血症を治療するオキシム誘導体
EP1456187A4 (en) * 2001-11-15 2005-02-09 Incyte San Diego Inc N-SUBSTITUTED HETEROCYCLES FOR THE TREATMENT OF HYPERCHOLESTERINEMIA, DYSLIPIDEMIA AND OTHER METABOLIC DISORDER, CANCER AND OTHER DISEASES
US7196108B2 (en) * 2002-03-08 2007-03-27 Incyte San Diego Inc. Bicyclic heterocycles for the treatment of diabetes and other diseases
US7102000B2 (en) * 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
US20050014767A1 (en) * 2003-01-29 2005-01-20 Magnus Pfahl Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases
ZA200509355B (en) * 2003-04-18 2007-03-28 Incyte San Diego Inc Substituted isochroman compounds for the treatment of metabolic disorders, cancer and other diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943635A (en) * 1987-08-27 1990-07-24 President & Fellows Of Harvard College Enantioselective reduction of ketones
US5036079A (en) * 1989-12-07 1991-07-30 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
TW222626B (da) * 1991-07-22 1994-04-21 Pfizer

Also Published As

Publication number Publication date
HUT70412A (en) 1995-10-30
IL102574A0 (en) 1993-01-14
WO1993002060A1 (en) 1993-02-04
DE69227689T2 (de) 1999-04-22
FI940306A0 (fi) 1994-01-21
ES2123562T3 (es) 1999-01-16
MY131277A (en) 2007-07-31
DK0595868T3 (da) 1999-08-09
NZ243651A (en) 1994-01-26
CA2111445C (en) 1997-02-18
ATE173728T1 (de) 1998-12-15
FI940306L (fi) 1994-01-21
JPH07502017A (ja) 1995-03-02
IL102574A (en) 1996-07-23
NO940227L (no) 1994-01-21
IE922359A1 (en) 1993-01-27
NO940227D0 (no) 1994-01-21
AU660701B2 (en) 1995-07-06
AU2306292A (en) 1993-02-23
EP0595868B1 (en) 1998-11-25
EP0595868A1 (en) 1994-05-11
CA2111445A1 (en) 1993-02-04
MX9204278A (es) 1994-03-31
FI940306A7 (fi) 1994-01-21
TW199891B (da) 1993-02-11
JP2671962B2 (ja) 1997-11-05
HU9400188D0 (en) 1994-05-30
US5512689A (en) 1996-04-30
PT100710A (pt) 1993-09-30
DE69227689D1 (de) 1999-01-07
ZA925469B (en) 1994-01-21

Similar Documents

Publication Publication Date Title
US5512689A (en) Process for the preparation of intermediates in the synthesis of chiral thiazolidine-2,4-dione derivatives
KR101156588B1 (ko) 에제티밉의 제조방법 및 이에 사용되는 중간체
WO2005049592A1 (en) A novel process for ezetimibe intermediate
EP0197432B1 (en) Enantioselective process for producing 1-beta-methylcarbapenem antibiotic intermediates
KR100355916B1 (ko) 디이소피노캄페일클로로보란의신규한제조방법
JPH0558630B2 (da)
US4791207A (en) Enantioselective process for producing 1-betamethylcarbapenem antibiotic intermediates
US5104984A (en) Enantioselective process for producing 1-beta-methyl carbapenem antibiotic intermediates
US5068345A (en) Oxazolidinone aldol adduct
JP2546559B2 (ja) ジイソピノカンフェイルクロロボランのインシトゥー製造
EP0177933B1 (en) Intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
KR100214907B1 (ko) 당뇨병 치료용 티아졸을 제조하기 위한 키랄 중간체
US4929740A (en) Process for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives
JPH02290887A (ja) ３‐ヒドロキシブチルアルデヒド誘導体の製造法
Haque Enantioselective hydrosilylation of prochiral alkenes using homochiral thiols as polarity-reversal catalysts
JP2001253841A (ja) ３−塩素化−１，１，１−トリフルオロ−２−置換−２−プロパノール類の製造方法
JPH07145093A (ja) ビタミンｄ誘導体の合成中間体の製造法
JPH04503522A (ja) トレオニン由来不整化学合成および抗真菌性化合物製造のための中間体
JPS6191150A (ja) プロスタトリエン酸誘導体の製造用中間体
ES466699A1 (es) Procedimiento de preparacion de derivados de prostaglandi- nas.
CA2085716A1 (en) Heterocyclically substituted carbamates and process for their preparation
JPS62205070A (ja) アミノエポキシアルコ−ル誘導体
EP0398474A3 (en) Oxazole derivatives and intermediates for their preparation
JPH01160927A (ja) ジシクロペンタジエン誘導体およびその製造方法

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19930527

FG3A Patent granted, date of granting

Effective date: 19990413

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20041013