PT1015449E - Derivados de (hetero)aril-sulfonamida, sua preparacao e sua utilizacao como inibidores do factor xa - Google Patents

Derivados de (hetero)aril-sulfonamida, sua preparacao e sua utilizacao como inibidores do factor xa

Info

Publication number: PT1015449E
Authority: PT; Portugal
Prior art keywords: optionally substituted; heterocyclic ring; preparation; antithrombotic; alkyl
Prior art date: 1997-07-29

Application number

PT98935200T

Other languages

English (en)

Inventor

John Preston

Stocker Andrew

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-29

Filing date

1998-07-23

Publication date

2005-04-29

1998-07-23 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2005-04-29 Publication of PT1015449E publication Critical patent/PT1015449E/pt

Links

229940123583 Factor Xa inhibitor Drugs 0.000 title 1
229940124530 sulfonamide Drugs 0.000 title 1
125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
230000002429 anti-coagulating effect Effects 0.000 abstract 2
230000002785 anti-thrombosis Effects 0.000 abstract 2
239000003146 anticoagulant agent Substances 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
238000004519 manufacturing process Methods 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PT98935200T 1997-07-29 1998-07-23 Derivados de (hetero)aril-sulfonamida, sua preparacao e sua utilizacao como inibidores do factor xa PT1015449E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9715895.0A GB9715895D0 (en)	1997-07-29	1997-07-29	Heterocyclic compounds

Publications (1)

Publication Number	Publication Date
PT1015449E true PT1015449E (pt)	2005-04-29

Family

ID=10816579

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT98935200T PT1015449E (pt)	1997-07-29	1998-07-23	Derivados de (hetero)aril-sulfonamida, sua preparacao e sua utilizacao como inibidores do factor xa

Country Status (10)

Country	Link
US (1)	US6486154B1 (pt)
EP (1)	EP1015449B1 (pt)
JP (1)	JP2001515077A (pt)
AT (1)	ATE286503T1 (pt)
AU (1)	AU8454998A (pt)
DE (1)	DE69828516T2 (pt)
ES (1)	ES2234133T3 (pt)
GB (1)	GB9715895D0 (pt)
PT (1)	PT1015449E (pt)
WO (1)	WO1999009027A1 (pt)

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EP1302462A4 (en) *	2000-07-17	2007-07-18	Takeda Pharmaceutical	SULFONATE DERIVATIVES, PROCESS FOR PRODUCTION AND USE THEREOF
WO2003000657A1 (en)	2001-06-20	2003-01-03	Daiichi Pharmaceutical Co., Ltd.	Diamine derivatives
DE10155075A1 (de) *	2001-11-09	2003-05-22	Merck Patent Gmbh	Cyclische Sulfonamide
CN100513398C (zh)	2002-12-03	2009-07-15	Axys药物公司	作为因子viia抑制剂的2-(2-羟基联苯-3-基)-1h-苯并咪唑-5-甲脒衍生物
WO2005019200A2 (en) *	2003-08-14	2005-03-03	Icos Corporation	Aryl piperidine derivatives as vla-1 integrin antagonists and uses thereof
TWI396686B (zh)	2004-05-21	2013-05-21	Takeda Pharmaceutical	環狀醯胺衍生物、以及其製品和用法
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CN105829296A (zh)	2013-12-18	2016-08-03	巴斯夫欧洲公司	带有亚胺衍生的取代基的唑类化合物

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1997
- 1997-07-29 GB GBGB9715895.0A patent/GB9715895D0/en active Pending
1998
- 1998-07-23 PT PT98935200T patent/PT1015449E/pt unknown
- 1998-07-23 US US09/463,446 patent/US6486154B1/en not_active Expired - Fee Related
- 1998-07-23 AT AT98935200T patent/ATE286503T1/de not_active IP Right Cessation
- 1998-07-23 ES ES98935200T patent/ES2234133T3/es not_active Expired - Lifetime
- 1998-07-23 WO PCT/GB1998/002200 patent/WO1999009027A1/en not_active Ceased
- 1998-07-23 DE DE69828516T patent/DE69828516T2/de not_active Expired - Fee Related
- 1998-07-23 AU AU84549/98A patent/AU8454998A/en not_active Abandoned
- 1998-07-23 JP JP2000509708A patent/JP2001515077A/ja active Pending
- 1998-07-23 EP EP98935200A patent/EP1015449B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69828516T2 (de)	2006-01-05
JP2001515077A (ja)	2001-09-18
WO1999009027A1 (en)	1999-02-25
EP1015449B1 (en)	2005-01-05
GB9715895D0 (en)	1997-10-01
AU8454998A (en)	1999-03-08
DE69828516D1 (de)	2005-02-10
EP1015449A1 (en)	2000-07-05
ES2234133T3 (es)	2005-06-16
ATE286503T1 (de)	2005-01-15
US6486154B1 (en)	2002-11-26

Publication	Publication Date	Title
AU692090B2 (en)	1998-05-28	Novel 4,6-diarylpyrimidine derivatives and salts thereof
YU20999A (sh)	2002-03-18	Heterociklični derivati koji inhibiraju faktor xa
ATE266007T1 (de)	2004-05-15	Heterocyclische verbindungen als faktor xa inhibitoren
PT1161428E (pt)	2003-10-31	Compostos de pirimidina
ID26179A (id)	2000-12-07	Turunan-turunan benzenasulfonamida dan penggunaannya sebagai obat-obatan
HUP9802323A2 (hu)	1999-03-29	Pirimidinszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyászati készítmények
ATE282610T1 (de)	2004-12-15	Heterozyklische verbindungen mit faktor xa hemmender wirkung
AU8454998A (en)	1999-03-08	(hetero)aryl-sulfonamide derivatives, their preparation and their use as factor xa inhibitors
KR920021547A (ko)	1992-12-18	아졸 유도체
ATE287874T1 (de)	2005-02-15	Heterozyklische verbindungen mit faktor xa hemmender wirkung
ATE13178T1 (de)	1985-05-15	2-oxoazetidin-derivate, ihre herstellung und verwendung.
DE3686979D1 (de)	1992-11-26	Cephemverbindungen und verfahren zu ihrer herstellung.
DE60000410D1 (de)	2002-10-10	Heterocyclische derivate als inhibitoren von faktor xa
NO20020804L (no)	2002-04-19	Nye A-500359-derivater
ATE48994T1 (de)	1990-01-15	Benzimidazol-derivat, verfahren zu seiner herstellung und pharmazeutische zusammensetzung.
FR2669030B1 (fr)	1992-12-31	Nouveaux derives d'imidazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ITMI920082A1 (it)	1993-07-17	Derivati solforati di acidi biliari
ATE131480T1 (de)	1995-12-15	Pyrimidoindolderivate und verfahren zu ihrer herstellung
RU94038051A (ru)	1996-05-27	Гетероциклические производные, способ их получения, фармацевтическая композиция и способ лечения