ATE282610T1 - Heterozyklische verbindungen mit faktor xa hemmender wirkung - Google Patents

Heterozyklische verbindungen mit faktor xa hemmender wirkung

Info

Publication number: ATE282610T1
Authority: AT; Austria
Prior art keywords: factor; heterocyclic compounds; inhibiting effect; relates; antithrombotic
Prior art date: 1998-05-02

Application number

AT99918178T

Other languages

English (en)

Inventor

Peter William Rodney Caulkett

Roger James

Stuart Eric Pearson

Anthony Michael Slater

Rolf Peter Walker

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-02

Filing date

1999-04-27

Publication date

2004-12-15

1998-05-02 Priority claimed from GBGB9809351.1A external-priority patent/GB9809351D0/en

1999-02-16 Priority claimed from GBGB9903337.5A external-priority patent/GB9903337D0/en

1999-04-27 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2004-12-15 Application granted granted Critical

2004-12-15 Publication of ATE282610T1 publication Critical patent/ATE282610T1/de

Links

108010074860 Factor Xa Proteins 0.000 title 1
150000002391 heterocyclic compounds Chemical class 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
230000002429 anti-coagulating effect Effects 0.000 abstract 2
230000002785 anti-thrombosis Effects 0.000 abstract 2
239000003146 anticoagulant agent Substances 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
238000004519 manufacturing process Methods 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
241001465754 Metazoa Species 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT99918178T 1998-05-02 1999-04-27 Heterozyklische verbindungen mit faktor xa hemmender wirkung ATE282610T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9809351.1A GB9809351D0 (en)	1998-05-02	1998-05-02	Heterocyclic derivatives
GBGB9903337.5A GB9903337D0 (en)	1999-02-16	1999-02-16	Heterocyclic derivatives
PCT/GB1999/001308 WO1999057113A1 (en)	1998-05-02	1999-04-27	Heterocyclic derivatives which inhibit factor xa

Publications (1)

Publication Number	Publication Date
ATE282610T1 true ATE282610T1 (de)	2004-12-15

Family

ID=26313572

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99918178T ATE282610T1 (de)	1998-05-02	1999-04-27	Heterozyklische verbindungen mit faktor xa hemmender wirkung

Country Status (22)

Country	Link
US (2)	US6753331B1 (de)
EP (2)	EP1082321B1 (de)
JP (1)	JP2002513790A (de)
KR (1)	KR20010043246A (de)
CN (1)	CN1133634C (de)
AT (1)	ATE282610T1 (de)
AU (1)	AU754453B2 (de)
BR (1)	BR9910179A (de)
CA (1)	CA2331042A1 (de)
DE (1)	DE69921994T2 (de)
EE (1)	EE200000527A (de)
ES (1)	ES2232131T3 (de)
HU (1)	HUP0101712A3 (de)
IL (1)	IL139406A (de)
NO (1)	NO320893B1 (de)
NZ (1)	NZ507835A (de)
PL (1)	PL343706A1 (de)
PT (1)	PT1082321E (de)
SI (1)	SI1082321T1 (de)
SK (1)	SK16512000A3 (de)
TR (1)	TR200003200T2 (de)
WO (1)	WO1999057113A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL115420A0 (en)	1994-09-26	1995-12-31	Zeneca Ltd	Aminoheterocyclic derivatives
GB9902989D0 (en)	1999-02-11	1999-03-31	Zeneca Ltd	Heterocyclic derivatives
GB9914342D0 (en) *	1999-06-19	1999-08-18	Zeneca Ltd	Compound
GB9917344D0 (en) *	1999-07-24	1999-09-22	Zeneca Ltd	Novel salt
TWI290136B (en)	2000-04-05	2007-11-21	Daiichi Seiyaku Co	Ethylenediamine derivatives
GB0012448D0 (en)	2000-05-24	2000-07-12	Astrazeneca Ab	New process
MXPA03004112A (es) *	2000-11-09	2003-08-19	Astrazeneca Ab	Composicion farmaceutica oral que contiene un copolimero de bloque.
GB0104752D0 (en) *	2001-02-27	2001-04-18	Astrazeneca Ab	Pharmaceutical compositions
WO2003000657A1 (en)	2001-06-20	2003-01-03	Daiichi Pharmaceutical Co., Ltd.	Diamine derivatives
AU2003302238A1 (en)	2002-12-03	2004-06-23	Axys Pharmaceuticals, Inc.	2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
WO2004108671A1 (en) *	2003-06-06	2004-12-16	Suven Life Sciences Limited	Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
WO2005012293A1 (ja) *	2003-08-01	2005-02-10	Nippon Soda Co., Ltd.	フェニルアゾール化合物、製造法および抗酸化薬
SE0400014D0 (sv)	2004-01-08	2004-01-08	Astrazeneca Ab	Heterocyclic derivatives
WO2007008143A1 (en) *	2005-07-08	2007-01-18	Astrazeneca Ab	Heterocyclic sulfonamide derivatives as inhibitors of factor xa
WO2007008144A1 (en) *	2005-07-08	2007-01-18	Astrazeneca Ab	Heterocyclic sulfonamide derivatives as inhibitors of factor xa
US20080221063A1 (en) *	2005-07-08	2008-09-11	Astrazeneca Ab	Heterocyclic Sulfonamide Derivatives As Inhibitors Of Factor Xa
WO2007008145A1 (en) *	2005-07-08	2007-01-18	Astrazeneca Ab	Heterocyclic sulfonamide derivatives as inhibitors of factor xa
BR112020018094A2 (pt)	2018-03-08	2020-12-22	Incyte Corporation	Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en)	2018-07-02	2021-06-29	Incyte Corporation	Aminopyrazine derivatives as PI3K-γ inhibitors
RS66218B1 (sr)	2019-07-01	2024-12-31	Tonix Pharma Ltd	Anti-cd154 antitela i njihove upotrebe
WO2022150452A1 (en)	2021-01-06	2022-07-14	Seth Lederman	Methods of inducing immune tolerance with modified anti-cd154 antibodies
WO2025248134A1 (en)	2024-05-31	2025-12-04	Tonix Pharma Limited	Treatment methods comprising administration of modified cd154 antibodies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL115420A0 (en)	1994-09-26	1995-12-31	Zeneca Ltd	Aminoheterocyclic derivatives
WO1997023212A1 (en) *	1995-12-21	1997-07-03	The Du Pont Merck Pharmaceutical Company	ISOXAZOLINE, ISOTHIAZOLINE AND PYRAZOLINE FACTOR Xa INHIBITORS
GB9602166D0 (en) *	1996-02-02	1996-04-03	Zeneca Ltd	Aminoheterocyclic derivatives
GB9602294D0 (en) *	1996-02-05	1996-04-03	Zeneca Ltd	Heterocyclic compounds
UA56197C2 (uk) *	1996-11-08	2003-05-15	Зенека Лімітед	Гетероциклічні похідні
WO1998054164A1 (en) *	1997-05-30	1998-12-03	Takeda Chemical Industries, Ltd.	Sulfonamide derivatives, their production and use
GB9715894D0 (en) *	1997-07-29	1997-10-01	Zeneca Ltd	Heterocyclic derivatives
DE19743435A1 (de) *	1997-10-01	1999-04-08	Merck Patent Gmbh	Benzamidinderivate

1999
- 1999-04-27 DE DE69921994T patent/DE69921994T2/de not_active Expired - Lifetime
- 1999-04-27 US US09/674,559 patent/US6753331B1/en not_active Expired - Fee Related
- 1999-04-27 EP EP99918178A patent/EP1082321B1/de not_active Expired - Lifetime
- 1999-04-27 CA CA002331042A patent/CA2331042A1/en not_active Abandoned
- 1999-04-27 TR TR2000/03200T patent/TR200003200T2/xx unknown
- 1999-04-27 NZ NZ507835A patent/NZ507835A/xx unknown
- 1999-04-27 HU HU0101712A patent/HUP0101712A3/hu unknown
- 1999-04-27 PT PT99918178T patent/PT1082321E/pt unknown
- 1999-04-27 PL PL99343706A patent/PL343706A1/xx not_active Application Discontinuation
- 1999-04-27 WO PCT/GB1999/001308 patent/WO1999057113A1/en not_active Ceased
- 1999-04-27 SK SK1651-2000A patent/SK16512000A3/sk unknown
- 1999-04-27 AU AU36206/99A patent/AU754453B2/en not_active Ceased
- 1999-04-27 AT AT99918178T patent/ATE282610T1/de not_active IP Right Cessation
- 1999-04-27 EP EP04022155A patent/EP1528061A1/de not_active Withdrawn
- 1999-04-27 SI SI9930725T patent/SI1082321T1/xx unknown
- 1999-04-27 BR BR9910179-3A patent/BR9910179A/pt not_active Application Discontinuation
- 1999-04-27 ES ES99918178T patent/ES2232131T3/es not_active Expired - Lifetime
- 1999-04-27 KR KR1020007012193A patent/KR20010043246A/ko not_active Ceased
- 1999-04-27 JP JP2000547083A patent/JP2002513790A/ja active Pending
- 1999-04-27 CN CNB99808218XA patent/CN1133634C/zh not_active Expired - Fee Related
- 1999-04-27 EE EEP200000527A patent/EE200000527A/xx unknown
- 1999-04-27 IL IL13940699A patent/IL139406A/en not_active IP Right Cessation
2000
- 2000-11-01 NO NO20005497A patent/NO320893B1/no unknown
2004
- 2004-04-06 US US10/817,960 patent/US20040266759A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN1308631A (zh)	2001-08-15
US6753331B1 (en)	2004-06-22
NO20005497L (no)	2000-12-21
WO1999057113A1 (en)	1999-11-11
DE69921994T2 (de)	2005-12-01
IL139406A (en)	2004-07-25
JP2002513790A (ja)	2002-05-14
CN1133634C (zh)	2004-01-07
TR200003200T2 (tr)	2001-02-21
EP1082321B1 (de)	2004-11-17
CA2331042A1 (en)	1999-11-11
DE69921994D1 (de)	2004-12-23
HUP0101712A2 (hu)	2001-11-28
EP1528061A1 (de)	2005-05-04
HUP0101712A3 (en)	2003-01-28
PT1082321E (pt)	2005-03-31
SK16512000A3 (sk)	2001-05-10
HK1034711A1 (en)	2001-11-02
AU3620699A (en)	1999-11-23
SI1082321T1 (en)	2005-06-30
NO20005497D0 (no)	2000-11-01
BR9910179A (pt)	2001-01-09
KR20010043246A (ko)	2001-05-25
EP1082321A1 (de)	2001-03-14
PL343706A1 (en)	2001-08-27
ES2232131T3 (es)	2005-05-16
EE200000527A (et)	2002-02-15
NZ507835A (en)	2003-01-31
AU754453B2 (en)	2002-11-14
IL139406A0 (en)	2001-11-25
NO320893B1 (no)	2006-02-06
US20040266759A1 (en)	2004-12-30

Legal Events

Date

Code

Title

Description

2005-06-15

UEP

Publication of translation of european patent specification

Ref document number: 1082321

Country of ref document: EP

2008-01-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE282610T1 (de)	2004-12-15	Heterozyklische verbindungen mit faktor xa hemmender wirkung
DE69823665D1 (de)	2004-06-09	Heterocyclische verbindungen als faktor xa inhibitoren
MY124122A (en)	2006-06-30	Heterocyclic derivatives
ATE287874T1 (de)	2005-02-15	Heterozyklische verbindungen mit faktor xa hemmender wirkung
AR029383A1 (es)	2003-06-25	Moleculas pequenas, los intermediarios para su sintesis, las composiciones farmaceuticas que las contienen y su uso para preparar un medicamento destinado al tratamiento o la profilaxis de enfermedades inflamatorias o mediadas por celulas inmunes
JO2353B1 (en)	2006-12-12	New derivatives of mixed-ring fluoroglycosides and drugs containing these compounds and their use
PT1015449E (pt)	2005-04-29	Derivados de (hetero)aril-sulfonamida, sua preparacao e sua utilizacao como inibidores do factor xa
NO20013921D0 (no)	2001-08-10	Heterosykliske derivater som inhibitorer av faktor XA