PT101627A - Polipeptideo trombopoietina isolado e substancialmente homogeneo, dna que o codifica e metodos recombinantes ou de sintese para a sua preparacao e purificacao - Google Patents

Polipeptideo trombopoietina isolado e substancialmente homogeneo, dna que o codifica e metodos recombinantes ou de sintese para a sua preparacao e purificacao

Info

Publication number
PT101627A
PT101627A PT101627A PT10162794A PT101627A PT 101627 A PT101627 A PT 101627A PT 101627 A PT101627 A PT 101627A PT 10162794 A PT10162794 A PT 10162794A PT 101627 A PT101627 A PT 101627A
Authority
PT
Portugal
Prior art keywords
polympeptidee
purification
synthesis
isolated
preparation
Prior art date
Application number
PT101627A
Other languages
English (en)
Other versions
PT101627B (pt
Inventor
Dan L Eaton
Frederic J De Sauvage
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/196,689 external-priority patent/US8357513B1/en
Priority claimed from US08/249,376 external-priority patent/US8192955B1/en
Priority claimed from US08/348,657 external-priority patent/US6660256B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PT101627A publication Critical patent/PT101627A/pt
Publication of PT101627B publication Critical patent/PT101627B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Vehicle Body Suspensions (AREA)
  • Information Transfer Systems (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PT101627A 1994-01-03 1994-12-30 Polipeptideo trombopoietina isolado e substancialmente homogeneo, dna que o codifica e metodos recombinantes ou de sintese para a sua preparacao e purificacao PT101627B (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17655394A 1994-01-03 1994-01-03
US18560794A 1994-01-21 1994-01-21
US08/196,689 US8357513B1 (en) 1994-01-03 1994-02-15 Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A 1994-04-04 1994-04-04
US08/249,376 US8192955B1 (en) 1994-01-03 1994-05-25 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US34865894A 1994-12-02 1994-12-02
US08/348,657 US6660256B1 (en) 1994-01-03 1994-12-02 Porcine mpl ligand

Publications (2)

Publication Number Publication Date
PT101627A true PT101627A (pt) 1995-11-30
PT101627B PT101627B (pt) 1996-11-29

Family

ID=27569151

Family Applications (1)

Application Number Title Priority Date Filing Date
PT101627A PT101627B (pt) 1994-01-03 1994-12-30 Polipeptideo trombopoietina isolado e substancialmente homogeneo, dna que o codifica e metodos recombinantes ou de sintese para a sua preparacao e purificacao

Country Status (28)

Country Link
EP (1) EP0738323A1 (pt)
JP (2) JPH09508262A (pt)
CN (1) CN1134539C (pt)
AU (1) AU704266B2 (pt)
BG (1) BG63639B1 (pt)
CA (1) CA2178482C (pt)
CZ (1) CZ296130B6 (pt)
DK (1) DK149194A (pt)
ES (1) ES2114786B1 (pt)
FI (1) FI121573B (pt)
FR (1) FR2714670B1 (pt)
GB (1) GB2285446B (pt)
HR (1) HRP941020A2 (pt)
HU (1) HUT75657A (pt)
IE (1) IE72517B1 (pt)
IL (1) IL112184A (pt)
IT (1) IT1283770B1 (pt)
LU (1) LU88573A1 (pt)
LV (1) LV11632B (pt)
NL (1) NL9500010A (pt)
NO (1) NO326903B1 (pt)
NZ (1) NZ278726A (pt)
PT (1) PT101627B (pt)
RO (1) RO117110B1 (pt)
SG (1) SG47030A1 (pt)
SI (1) SI9420079A (pt)
SK (1) SK282265B6 (pt)
WO (1) WO1995018858A1 (pt)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6270989B1 (en) * 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5968502A (en) 1991-11-05 1999-10-19 Transkaryotic Therapies, Inc. Protein production and protein delivery
NZ271230A (en) * 1994-02-14 1998-03-25 Zymogenetics Inc Hematopoietic proteins, production and use
DE69503849T2 (de) * 1994-03-31 1999-04-01 Amgen Inc., Thousand Oaks, Calif. Zusammensetzungen und Verfahren zur Anregung des Wachstums und der Differenzierung von Megakaryozyten
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
TW387940B (en) * 1995-01-17 2000-04-21 Kirin Brewery Anti-tpo monodonal antibody
US6254870B1 (en) 1995-02-03 2001-07-03 G. D. Searle & Co. Thrombopoietin: IL-3 fusion protein
US5696250A (en) 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
CA2209298C (en) * 1995-02-15 2001-12-18 Amgen Inc. Mpl ligand analogs
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
ZA964382B (en) * 1995-06-06 1997-12-01 Genentech Inc Lymphotoxin and thrombopoietin for use in the treatment of cancer.
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
EA001220B1 (ru) 1995-06-07 2000-12-25 Глаксо Груп Лимитед Пептид или пептидомиметик, который связывается с рецептором тромбоэтина, фармацевтическая композиция и способ лечения
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
EP0920511A1 (en) * 1996-08-13 1999-06-09 ZymoGenetics Expression vectors, cells, and methods for preparing thrombopoietin polypeptides
JP4562815B2 (ja) * 1997-05-21 2010-10-13 ジェネンテック， インコーポレイテッド トロンボポエチンの新規な投与
US5980893A (en) * 1997-07-17 1999-11-09 Beth Israel Deaconess Medical Center, Inc. Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
KR20000006549A (ko) * 1998-06-30 2000-01-25 윤재승 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체
HK1042114B (zh) 1998-10-23 2006-09-29 Amgen K-A, Inc. 与mp1受体结合并具有血小板生成活性的模拟二聚体血小板生成素肽
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
UY26317A1 (es) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
WO2003041495A1 (en) 2001-11-15 2003-05-22 Kirin Beer Kabushiki Kaisha Chimeric nonhuman animal
KR100467750B1 (ko) * 2001-11-29 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
CA2499625A1 (en) 2002-09-18 2004-04-01 Ortho-Mcneil Pharmaceutical, Inc. Methods of increasing platelet and hematopoietic stem cell production
UA82710C2 (uk) 2003-08-28 2008-05-12 Орто-Макнейл Фармацевтикал, Инк. Пептид, що зв'язується з тромбопоетиновим рецептором (варіанти), та спосіб лікування тромбоциторенії (варіанти)
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
EP1751298A4 (en) 2004-05-18 2009-11-11 Intrexon Corp METHOD FOR DYNAMIC VECTOR ASSEMBLY OF DNA CLONING VECTOR PLASMIDES
CA2572765C (en) 2004-07-08 2013-05-21 Amgen Inc. Compound having improved bioefficiency when administered in a multidose regimen
US7442778B2 (en) 2004-09-24 2008-10-28 Amgen Inc. Modified Fc molecules
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US9012605B2 (en) 2006-01-23 2015-04-21 Amgen Inc. Crystalline polypeptides
WO2007098547A1 (en) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
AU2007278748B2 (en) 2006-07-24 2013-08-15 The University Of Queensland Method of producing a population of cells
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
EP2738257A1 (en) 2007-05-22 2014-06-04 Amgen Inc. Compositions and methods for producing bioactive fusion proteins
KR101040396B1 (ko) 2009-01-20 2011-06-09 한올바이오파마주식회사 변형된 인간 트롬보포이에틴 폴리펩타이드 절편 및 그의 제조방법
WO2014089478A1 (en) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same
CN114558032B (zh) 2012-12-21 2025-07-29 安斯泰来再生医药协会 由多能干细胞制备血小板的方法及其组合物
CN103555760B (zh) * 2013-10-18 2015-05-20 江苏康禾生物制药有限公司 一种重组人血小板生成素的制备方法及其制剂
WO2017111215A1 (ko) * 2015-12-21 2017-06-29 주식회사 브레인온 기억력, 학습력, 인지력 향상용 조성물
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
AU2020349991A1 (en) * 2019-09-20 2022-04-07 Ractigen Therapeutics Nucleic acid molecule for treating immune thrombocytopenia and application thereof
KR20220119439A (ko) 2019-12-20 2022-08-29 인스틸 바이오 유케이 리미티드 종양 침윤 림프구를 분리하기 위한 장치 및 방법 및 그것의 용도
CN118086536A (zh) * 2024-04-23 2024-05-28 佛山科学技术学院 一种通过snp标记改善黄牛血小板生成素分泌的方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260417A (en) 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
ATE204606T1 (de) * 1991-12-06 2001-09-15 Genentech Inc Prohormon konvertase transformierte zellen.
IL139335A (en) 1994-01-03 2005-08-31 Genentech Inc Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia

Also Published As

Publication number Publication date
SK87596A3 (en) 1997-11-05
SI9420079A (en) 1997-02-28
CA2178482C (en) 2012-01-03
CZ192296A3 (en) 1997-05-14
LV11632B (en) 1997-04-20
EP0738323A1 (en) 1996-10-23
CA2178482A1 (en) 1995-07-13
NZ278726A (en) 1998-06-26
NO962783D0 (no) 1996-07-02
GB2285446B (en) 1999-07-28
CN1134539C (zh) 2004-01-14
SK282265B6 (sk) 2001-12-03
SG47030A1 (en) 1998-03-20
GB2285446A (en) 1995-07-12
IE72517B1 (en) 1997-04-23
IE950002A1 (en) 1995-07-12
CN1141061A (zh) 1997-01-22
RO117110B1 (ro) 2001-10-30
IL112184A (en) 2004-07-25
JPH09508262A (ja) 1997-08-26
NL9500010A (nl) 1995-08-01
HUT75657A (en) 1997-05-28
FI962723A0 (fi) 1996-07-02
LV11632A (lv) 1996-12-20
AU1514695A (en) 1995-08-01
NO326903B1 (no) 2009-03-16
JPH10113186A (ja) 1998-05-06
WO1995018858A1 (en) 1995-07-13
DK149194A (da) 1995-07-04
NO962783L (no) 1996-09-03
IL112184A0 (en) 1995-03-15
FR2714670B1 (fr) 1997-01-10
ES2114786B1 (es) 1999-01-01
LU88573A1 (de) 1995-06-01
FI962723L (fi) 1996-09-03
GB9425831D0 (en) 1995-02-22
FR2714670A1 (fr) 1995-07-07
AU704266B2 (en) 1999-04-15
HU9601805D0 (en) 1996-08-28
HRP941020A2 (en) 1997-04-30
ES2114786A1 (es) 1998-06-01
BG63639B1 (bg) 2002-07-31
PT101627B (pt) 1996-11-29
FI121573B (fi) 2011-01-14
ITTO950002A0 (it) 1995-01-02
BG100693A (en) 1998-01-30
IT1283770B1 (it) 1998-04-30
ITTO950002A1 (it) 1996-07-02
CZ296130B6 (cs) 2006-01-11

Similar Documents

Publication Publication Date Title
BR9605919A (pt) Catalisadores e processos para sua preparação
DE69532847D1 (de) System zur Seitenanalyse
DE69521077D1 (de) Mikrotitriersystem
NO975731D0 (no) Katalytisk DNA
IL116527A0 (en) Dna molecules coding for plant proteins
FI964098A7 (fi) Parranajokonejärjestelmä
DE69724557D1 (de) Dokumentenanalyse
FI954648L (fi) Proteiinien erottaminen
AU2945795A (en) DNA encoding an 18 Kd CDK6 inhibiting protein
BR9501980A (pt) Copolimeros,processo para sua preparação
DK121993D0 (da) Graded catalyst system
DE59507551D1 (de) Transponder-Abfragesystem
FI941867A0 (fi) Reagenssiallas
DE59505759D1 (de) Binderrücken
DE69521992D1 (de) Probenahmeventil
FR2718531B1 (fr) Plaque de microtitrage.
DK138094A (da) Alkyleringsproces
DE69514906D1 (de) Betätigungssystem
AU4602396A (en) Dna encoding a 20 kd cdk6 inhibiting protein
NO962736L (no) Modifiserte harpikser
EP0705320A4 (en) Catalytic cracking system
ATA203894A (de) Rekombinante dna moleküle
FI970002A0 (fi) Venttiilijärjestelmä
DE69519715D1 (de) PRLTS-Proteine und die dafür kodierende DNA
FI953885A0 (fi) Käyttökoneisto

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19960820

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20141230