PT102006A - Novo processo de preparacao de azitromicina - Google Patents

Novo processo de preparacao de azitromicina Download PDF

Info

Publication number: PT102006A
Authority: PT; Portugal
Prior art keywords: azitromycin; new; preparation process; azithromycin; formaldehyde
Prior art date: 1997-05-19

Application number

PT102006A

Other languages

English (en)

Other versions

PT102006B (pt

Inventor

William Heggie

Zita Maria De Mouro Vaz Mendes

Original Assignee

Hovione Sociedade Quimica S A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-19

Filing date

1997-05-19

Publication date

1998-12-31

1997-05-19 Application filed by Hovione Sociedade Quimica S A filed Critical Hovione Sociedade Quimica S A

1997-05-19 Priority to PT102006A priority Critical patent/PT102006B/pt

1998-04-17 Priority to AU61938/98A priority patent/AU722688B2/en

1998-04-20 Priority to NZ330228A priority patent/NZ330228A/xx

1998-04-21 Priority to JP11041098A priority patent/JP3899181B2/ja

1998-04-27 Priority to IN1094DE1998 priority patent/IN189736B/en

1998-05-10 Priority to IL12439798A priority patent/IL124397A/xx

1998-05-15 Priority to CA002237747A priority patent/CA2237747C/en

1998-05-15 Priority to HU9801094A priority patent/HUP9801094A3/hu

1998-05-18 Priority to US09/080,856 priority patent/US6013778A/en

1998-05-18 Priority to CN98108489A priority patent/CN1125076C/zh

1998-05-19 Priority to EP98303945A priority patent/EP0879823B1/en

1998-05-19 Priority to DE69810842T priority patent/DE69810842T2/de

1998-05-19 Priority to ES98303945T priority patent/ES2191256T3/es

1998-05-19 Priority to AT98303945T priority patent/ATE231516T1/de

1998-12-31 Publication of PT102006A publication Critical patent/PT102006A/pt

2000-06-30 Publication of PT102006B publication Critical patent/PT102006B/pt

Links

238000002360 preparation method Methods 0.000 title 1
238000006243 chemical reaction Methods 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 abstract 1
229960004099 azithromycin Drugs 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract 1
ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical compound O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 abstract 1
229910000510 noble metal Inorganic materials 0.000 abstract 1
238000006722 reduction reaction Methods 0.000 abstract 1
238000006485 reductive methylation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Indole Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Catalysts (AREA)

PT102006A 1997-05-19 1997-05-19 Novo processo de preparacao de azitromicina PT102006B (pt)

Priority Applications (14)

Application Number	Priority Date	Filing Date	Title
PT102006A PT102006B (pt)	1997-05-19	1997-05-19	Novo processo de preparacao de azitromicina
AU61938/98A AU722688B2 (en)	1997-05-19	1998-04-17	New process for the preparation of azithromycin
NZ330228A NZ330228A (en)	1997-05-19	1998-04-20	Process for preparing azithromycin using a noble metal catalyst and hydrogen in the presence formaldehyde
JP11041098A JP3899181B2 (ja)	1997-05-19	1998-04-21	アジスロマイシンの新規な製造方法
IN1094DE1998 IN189736B (pt)	1997-05-19	1998-04-27
IL12439798A IL124397A (en)	1997-05-19	1998-05-10	One-pot process for the preparation of azithromycin
CA002237747A CA2237747C (en)	1997-05-19	1998-05-15	New process for the preparation of azithromycin
HU9801094A HUP9801094A3 (en)	1997-05-19	1998-05-15	Process for producing azithromycin
US09/080,856 US6013778A (en)	1997-05-19	1998-05-18	Process for the preparation of azithromycin
CN98108489A CN1125076C (zh)	1997-05-19	1998-05-18	制备阿泽红霉素的方法
EP98303945A EP0879823B1 (en)	1997-05-19	1998-05-19	Preparation of azithromycin
DE69810842T DE69810842T2 (de)	1997-05-19	1998-05-19	Herstellung von Azithromycin
ES98303945T ES2191256T3 (es)	1997-05-19	1998-05-19	Preparacion de azitromicina.
AT98303945T ATE231516T1 (de)	1997-05-19	1998-05-19	Herstellung von azithromycin

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PT102006A PT102006B (pt)	1997-05-19	1997-05-19	Novo processo de preparacao de azitromicina

Publications (2)

Publication Number	Publication Date
PT102006A true PT102006A (pt)	1998-12-31
PT102006B PT102006B (pt)	2000-06-30

Family

ID=20085680

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT102006A PT102006B (pt)	1997-05-19	1997-05-19	Novo processo de preparacao de azitromicina

Country Status (14)

Country	Link
US (1)	US6013778A (pt)
EP (1)	EP0879823B1 (pt)
JP (1)	JP3899181B2 (pt)
CN (1)	CN1125076C (pt)
AT (1)	ATE231516T1 (pt)
AU (1)	AU722688B2 (pt)
CA (1)	CA2237747C (pt)
DE (1)	DE69810842T2 (pt)
ES (1)	ES2191256T3 (pt)
HU (1)	HUP9801094A3 (pt)
IL (1)	IL124397A (pt)
IN (1)	IN189736B (pt)
NZ (1)	NZ330228A (pt)
PT (1)	PT102006B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6861411B1 (en)	1997-12-02	2005-03-01	Pfizer, Inc.	Method of treating eye infections with azithromycin
TW546302B (en) *	1998-05-08	2003-08-11	Biochemie Sa	Improvements in macrolide production
FR2791680B1 (fr) *	1999-03-29	2001-06-29	Merial Sas	Procede utile pour reduire les intermediaires imidates issus d'un rearrangement de beckmann d'un macrocycle 8a-azalide
US6239113B1 (en)	1999-03-31	2001-05-29	Insite Vision, Incorporated	Topical treatment or prevention of ocular infections
US7056893B2 (en)	1999-03-31	2006-06-06	Insite Vision, Inc.	Topical treatment for prevention of ocular infections
FR2806724B1 (fr) *	2000-03-24	2003-12-05	Merial Sas	Procede pour la preparation de derives 9-deoxo-8a-aza- (8a-alkyl)-8a-homoerythromycine a a partir de la 9-deoxo-9 (z)-hydroxyiminoerythromycine a
DE60026718T2 (de)	2000-07-25	2006-11-16	Laboratorio Silanes, S.A. De C.V.	Einstufiges verfahren zur herstellung von 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle(11.2.11)hexadeca-1(2)-en-8-ona undeine neue form von 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin a
JP2004506664A (ja) *	2000-08-23	2004-03-04	ウォックハート・リミテッド	無水アジトロマイシンの製造法
CN100341886C (zh) *	2000-11-27	2007-10-10	桑多斯股份公司	大环内酯类化合物的溶剂化物
HRP20030430B1 (hr) *	2000-11-27	2011-11-30	Biochemie S.A.	Makrolidni solvati
ES2179756B1 (es) *	2000-11-30	2004-10-01	Ercros Industrial, S.A.	Procedimiento de obtencion de azaeritromicina.
KR100491183B1 (ko)	2001-03-21	2005-05-25	한미약품 주식회사	아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
ITMI20021209A1 (it) *	2002-06-04	2003-12-04	Chemi Spa	Processo di preparazione di azitromicina ad elevata purezza
US7468428B2 (en)	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
US20060116336A1 (en) *	2004-03-17	2006-06-01	American Pharmaceutical Partners, Inc.	Lyophilized azithromycin formulation
US7683162B2 (en) *	2004-08-30	2010-03-23	Taro Pharmaceutical Industries Limited	Process of preparing a crystalline azithromycin monohydrate
CN1304407C (zh) *	2004-09-03	2007-03-14	南京圣和药业有限公司	一种阿奇霉素的精制方法
ES2407033T3 (es)	2007-05-04	2013-06-11	Mallinckrodt Llc	Procedimientos mejorados para la preparación de opiáceos 6-alfa-hidroxi-n-alquilados
JP2010533719A (ja)	2007-07-17	2010-10-28	マリンクロッド・インコーポレイテッド	還元的アミノ化によるｎ−アルキル化オピエートの調製
NZ607842A (en)	2008-09-30	2013-12-20	Mallinckrodt Llc	Processes for the selective amination of ketomorphinans
EP2358732B1 (en) *	2008-10-24	2013-06-19	Merial Ltd.	Method of synthesizing macrolide compounds
US8946419B2 (en)	2009-02-23	2015-02-03	Mallinckrodt Llc	(+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8519133B2 (en)	2009-06-11	2013-08-27	Mallinckrodt Llc	Preparation of 6-alpha-amino N-substituted morphinans by catalytic hydrogen transfer
US8471023B2 (en)	2009-06-11	2013-06-25	Mallinckrodt Llc	Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
KR20140036215A (ko)	2011-06-09	2014-03-25	말린크로트 엘엘씨	촉매 수소 전달에 의한 6-케토 모르피난의 환원 아미노화
MX2014002630A (es)	2011-09-08	2014-04-14	Mallinckrodt Llc	Produccion de alcaloides sin el aislamiento de compuestos intermediarios.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI8110592A8 (en) *	1981-03-06	1996-06-30	Pliva Pharm & Chem Works	Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) *	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
PH19293A (en) *	1982-11-15	1986-03-04	Pfizer	Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
US5686587A (en) *	1993-05-19	1997-11-11	Pfizer Inc.	Intermediate for azithromycin

1997
- 1997-05-19 PT PT102006A patent/PT102006B/pt not_active IP Right Cessation
1998
- 1998-04-17 AU AU61938/98A patent/AU722688B2/en not_active Ceased
- 1998-04-20 NZ NZ330228A patent/NZ330228A/xx unknown
- 1998-04-21 JP JP11041098A patent/JP3899181B2/ja not_active Expired - Fee Related
- 1998-04-27 IN IN1094DE1998 patent/IN189736B/en unknown
- 1998-05-10 IL IL12439798A patent/IL124397A/xx not_active IP Right Cessation
- 1998-05-15 CA CA002237747A patent/CA2237747C/en not_active Expired - Fee Related
- 1998-05-15 HU HU9801094A patent/HUP9801094A3/hu active IP Right Revival
- 1998-05-18 US US09/080,856 patent/US6013778A/en not_active Expired - Fee Related
- 1998-05-18 CN CN98108489A patent/CN1125076C/zh not_active Expired - Fee Related
- 1998-05-19 AT AT98303945T patent/ATE231516T1/de active
- 1998-05-19 DE DE69810842T patent/DE69810842T2/de not_active Expired - Fee Related
- 1998-05-19 EP EP98303945A patent/EP0879823B1/en not_active Expired - Lifetime
- 1998-05-19 ES ES98303945T patent/ES2191256T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US6013778A (en)	2000-01-11
HUP9801094A3 (en)	2000-03-28
CN1199736A (zh)	1998-11-25
DE69810842D1 (de)	2003-02-27
NZ330228A (en)	1999-06-29
ES2191256T3 (es)	2003-09-01
DE69810842T2 (de)	2003-11-20
EP0879823A1 (en)	1998-11-25
HU9801094D0 (en)	1998-07-28
HUP9801094A2 (hu)	1998-12-28
CA2237747A1 (en)	1998-11-19
JPH10316699A (ja)	1998-12-02
ATE231516T1 (de)	2003-02-15
IL124397A (en)	2003-09-17
IN189736B (pt)	2003-04-19
AU6193898A (en)	1998-11-19
IL124397A0 (en)	1998-12-06
CN1125076C (zh)	2003-10-22
EP0879823B1 (en)	2003-01-22
PT102006B (pt)	2000-06-30
JP3899181B2 (ja)	2007-03-28
AU722688B2 (en)	2000-08-10
CA2237747C (en)	2007-04-10

Legal Events

Date	Code	Title	Description
1998-12-31	BB1A	Laying open of patent application	Effective date: 19970731
2000-06-30	FG3A	Patent granted, date of granting	Effective date: 20000320
2012-10-09	MA3A	Withdrawal of patent	Effective date: 20120611

Publication	Publication Date	Title
PT102006A (pt)	1998-12-31	Novo processo de preparacao de azitromicina
IT1318550B1 (it)	2003-08-27	Catalizzatore e processo per la sintesi diretta di acqua ossigenata.
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DE69924288D1 (de)	2005-04-21	Verfahren zur oxidation von in wasserstoff enthaltenem co
BR0014995A (pt)	2002-06-18	Processo de oxidação parcial catalìtica
NO20013333L (no)	2002-01-07	Fremgangsmåte for katalytisk ammoniakkfremstilling - fremgangsmåte og gjenvinning av ammoniakk-syntesekatalysator
AU3303499A (en)	1999-09-15	Spent caustic pretreatment and enhanced oxidation process
DE59905380D1 (de)	2003-06-12	Reaktor für eine katalytische chemische Reaktion, insbesondere Methanolreformierungsreaktor
MY114087A (en)	2002-08-30	Oxidation process
DE59903250D1 (de)	2002-12-05	Röhrenreaktor für katalytische reaktionen
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DK0888268T3 (da)	2003-03-03	Fremgangsmåde til cyclotrimerisering af alkyner i vandige opløsninger
AU5361398A (en)	1998-08-03	Reforming process with catalyst pretreatment
BR9809485A (pt)	2000-06-20	Processo para epoxidação catalìtica e alqueno.
FI910492A7 (fi)	1991-08-03	Alkalimetalleja tai maa-alkalimetalleja sisältävä kemiallinen yhdiste,tätä yhdistettä sisältävä katalyytti ja reaktioprosessi, jossa käytetään tätä katalyyttiä
IL133444A0 (en)	2001-04-30	A method for replacing a physical catalyst in a chemical reaction system with a spectral catalyst
MY119687A (en)	2005-06-30	Selective oxidation process and catalyst therefor
EP1591416A3 (en)	2006-11-22	Process for reducing concentration of carbon monoxide in hydrogen-containing gas and catalyst used therefor
DE69100575D1 (de)	1993-12-09	Vorbehandlungsverfahren eines Reformierkatalysators.
AU7806398A (en)	1998-12-21	Catalyst for oxidative nef reaction using basic hydrogen peroxide
KR920002222A (ko)	1992-02-28	비활성 및 독성화된 백금 촉매의 재생방법
AU5824790A (en)	1991-01-07	Catalyst for heterogeneous catalysis consisting of an alloy of transition metals
ZA991522B (en)	2000-05-29	Reactor for hydrogen cyanide gas production.
AU3027599A (en)	1999-08-30	Metallic reactor tube with catalytic coating