PT1161232E - Sulfonamidas de hidroxidifenilureia como antagonistas do receptor de il-8 - Google Patents

Sulfonamidas de hidroxidifenilureia como antagonistas do receptor de il-8

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Publication number
PT1161232E
PT1161232E PT99965288T PT99965288T PT1161232E PT 1161232 E PT1161232 E PT 1161232E PT 99965288 T PT99965288 T PT 99965288T PT 99965288 T PT99965288 T PT 99965288T PT 1161232 E PT1161232 E PT 1161232E
Authority
PT
Portugal
Prior art keywords
hydroxidifenilureia
sulfonamides
receptor antagonists
antagonists
receptor
Prior art date
Application number
PT99965288T
Other languages
English (en)
Portuguese (pt)
Inventor
Qi Jin
Brent W Mccleland
Michael R Palovich
Katherine L Widdowson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PT1161232E publication Critical patent/PT1161232E/pt

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    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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PT99965288T 1998-12-16 1999-12-15 Sulfonamidas de hidroxidifenilureia como antagonistas do receptor de il-8 PT1161232E (pt)

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Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517880B2 (en) * 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
EP1158985B1 (fr) 1999-01-13 2011-12-28 Bayer HealthCare LLC DIPHENYLE UREES A SUBSTITUTION OMEGA-CARBOXY ARYLE EN TANT QU'INHIBITEURS DE LA KINASE p38
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ME00275B (fr) 1999-01-13 2011-02-10 Bayer Corp DIPHENYLUREES A SUBSTITUANTS ω-CARBOXYARYLES, INHIBITRICES DE KINASE RAF
EP1140840B1 (fr) * 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. Diphenylurees a substituants -g(v)-carboxyaryles, inhibitrices de kinase raf
AR029637A1 (es) 1999-05-28 2003-07-10 Smithkline Beecham Corp Compuestos de guanidina, antagonistas de los receptores de la il-8, una composicion farmaceutica que los contiene y el uso de los mismos para la manufactura de un medicamento
WO2001064691A1 (fr) * 2000-03-01 2001-09-07 Smithkline Beecham Corporation Antagonistes du recepteur de l'interleukine 8 (il-8)
JP2004504270A (ja) * 2000-03-10 2004-02-12 スミスクライン・ビーチャム・コーポレイション Il−8受容体アンタゴニスト
MY133845A (en) * 2000-03-10 2007-11-30 Smithkline Beecham Corp Il-8 receptor antagonists
AR030689A1 (es) * 2000-03-14 2003-09-03 Smithkline Beecham Corp Compuestos de 3-aminosulfonil-2-hidroxifenil urea, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos en la manufactura de medicamentos para tratar enfermedades mediadas por quimioquinas
JP2003527360A (ja) * 2000-03-14 2003-09-16 スミスクライン・ビーチャム・コーポレイション Il−8受容体アンタゴニスト
CO5280089A1 (es) * 2000-03-16 2003-05-30 Smithkline Beecham Corp Antagonistas del receptor il-8
US6664259B2 (en) * 2000-03-16 2003-12-16 Smithkline Beecham Corporation Il-8 receptor antagonists
UY26627A1 (es) * 2000-03-24 2001-09-28 Smithkline Beecham Corp Antagonistas de receptores de il-8
US6653310B2 (en) 2000-04-07 2003-11-25 Smithkline Beecham Corporation IL-8 receptor antagonists
WO2002012243A2 (fr) * 2000-08-09 2002-02-14 Boehringer Ingelheim Pharmaceuticals, Inc. Synthese de (r)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo--3-methyl-1-h-imidazo[1,2-a]imidazol-2-one
JP4224566B2 (ja) * 2000-12-18 2009-02-18 株式会社医薬分子設計研究所 炎症性サイトカイン産生遊離抑制剤
DE60216229T2 (de) * 2001-01-16 2007-10-04 Smithkline Beecham Corp. Il-8-rezeptorantagonisten
EP1383488A2 (fr) * 2001-03-30 2004-01-28 SmithKline Beecham Corporation Procedes de synthese de composes contenant un phenol
TW200303742A (en) * 2001-11-21 2003-09-16 Novartis Ag Organic compounds
US20030207872A1 (en) * 2002-01-11 2003-11-06 Bayer Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
SI1478358T1 (sl) 2002-02-11 2013-09-30 Bayer Healthcare Llc Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi
EP1512396A4 (fr) * 2002-06-05 2008-12-31 Inst Med Molecular Design Inc Inhibiteurs de l'activation de ap-1 et de nfat
CA2488363C (fr) 2002-06-06 2011-01-04 Institute Of Medicinal Molecular Design, Inc. Derives hydroxyaryle o-substitues
TW200418812A (en) * 2002-10-29 2004-10-01 Smithkline Beecham Corp IL-8 receptor antagonists
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
EP1636585B2 (fr) 2003-05-20 2012-06-13 Bayer HealthCare LLC Diaryl-urees presentant une activite d'inhibition des kinases
EP1663978B1 (fr) 2003-07-23 2007-11-28 Bayer Pharmaceuticals Corporation Omega-carboxyaryldiphenyluree fluoro-subtituee pour le traitement et la prevention de maladies et d'etats pathologiques
EP1812008A4 (fr) * 2004-10-20 2008-10-29 Smithkline Beecham Corp Antagonistes du récepteur il-8
PL2009992T3 (pl) 2006-04-21 2012-11-30 Glaxosmithkline Llc Antagoniści receptora IL-8
US8097626B2 (en) * 2006-04-21 2012-01-17 Glaxosmithkline Llc IL-8 receptor antagonists
US7671058B2 (en) 2006-06-21 2010-03-02 Institute Of Medicinal Molecular Design, Inc. N-(3,4-disubstituted phenyl) salicylamide derivatives
CL2007001829A1 (es) * 2006-06-23 2008-01-25 Smithkline Beecham Corp P-toluensulfonato de n-[4-cloro-2-hidroxi-3-(piperazina-1-sulfonil)fenil]-n-(2-cloro-3-fluorofenil)urea;procedimiento de preparacion;composicion farmaceutica;combinacion farmaceutica;y uso en el tratamiento de una enfermedad mediada por la quiimioquina il-8, tales como asma y epoc.
EP2203432A4 (fr) * 2007-09-21 2011-04-27 Glaxosmithkline Llc Procédé de traitement
EP2110019A1 (fr) 2008-04-19 2009-10-21 Bayer CropScience AG Composés herbicides à base de N-azinyl-N'-pyridylsulfonylurées
US20120121515A1 (en) 2009-03-13 2012-05-17 Lenny Dang Methods and compositions for cell-proliferation-related disorders
TWI598337B (zh) 2009-06-29 2017-09-11 阿吉歐斯製藥公司 治療化合物及組成物
EP2491015A1 (fr) * 2009-10-21 2012-08-29 Bayer Pharma Aktiengesellschaft Benzosulfonamides substitués
WO2011050210A1 (fr) 2009-10-21 2011-04-28 Agios Pharmaceuticals, Inc. Procedes et compositions pour des troubles relatifs
EP2525790B1 (fr) 2009-10-21 2020-05-27 Agios Pharmaceuticals, Inc. Procédés et compositions pour troubles associés à la prolifération cellulaire
EP2512465A1 (fr) 2009-12-17 2012-10-24 Galderma Research & Development Utilisation de composés dans traitement ou prévention d'affections cutanées
SMT202400081T1 (it) 2011-05-03 2024-03-13 Agios Pharmaceuticals Inc Attivatori della piruvato chinasi per uso in terapia
CN102827073A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
CN102827170A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
PE20142098A1 (es) 2012-01-06 2015-01-08 Agios Pharmaceuticals Inc Compuestos terapeuticamente activos y sus metodos de uso
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
EP2906212A4 (fr) 2012-10-15 2016-06-08 Agios Pharmaceuticals Inc Composés et compositions thérapeutiques
WO2015003360A2 (fr) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Composés thérapeutiquement actifs et leurs méthodes d'utilisation
CN105593215B (zh) 2013-07-11 2019-01-15 安吉奥斯医药品有限公司 用于治疗癌症的作为idh2突变体抑制剂的2,4-或4,6-二氨基嘧啶化合物
AU2014287122B9 (en) 2013-07-11 2018-11-01 Les Laboratoires Servier N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as IDH2 mutants inhibitors for the treatment of cancer
WO2015003355A2 (fr) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Composés thérapeutiquement actifs et leurs méthodes d'utilisation
WO2015010297A1 (fr) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc. Composés thérapeutiquement actifs et leurs méthodes d'utilisation
NZ723859A (en) 2014-03-14 2023-01-27 Servier Lab Pharmaceutical compositions of therapeutically active compounds and their uses
FR3030515B1 (fr) * 2014-12-23 2017-01-20 Galderma Res & Dev Nouveaux composes antagonistes des recepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies mediees par des chimiokines
CA2989111C (fr) 2015-06-11 2023-10-03 Agios Pharmaceuticals, Inc. Procedes d'utilisation d'activateurs de la pyruvate kinase
FI3362065T3 (fi) 2015-10-15 2024-06-19 Servier Lab Ivosidenibiä, sytarabiinia ja daunorubisiinia tai idarubisiinia käsittävä yhdistelmähoito akuutin myelooisen leukemian hoitamiseksi
KR102699521B1 (ko) 2015-10-15 2024-08-26 르 라보레또레 쎄르비에르 악성 종양의 치료를 위한 조합물 요법
US10980788B2 (en) 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
CN112778167A (zh) * 2019-11-01 2021-05-11 邵阳学院 一种快速制备n-苯磺酰基氨基酸酯类化合物的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3972886A (en) * 1972-07-13 1976-08-03 Leo Pharmaceutical Products Ltd. Certain 4-phenoxy-3-heteroarylmethyl or ethyl sulfamyl benzoic acid derivatives
US4155930A (en) 1978-07-11 1979-05-22 American Cyanamid Company Ureylene phenylene anionic naphthalenesulfonic acids
US4786316A (en) 1984-07-13 1988-11-22 E. I. Du Pont De Nemours And Company Herbicidal ortho-sulfamoyl sulfonamides
US6271261B1 (en) * 1996-06-27 2001-08-07 Smithkline Beecham Corporation IL-8 receptor antagonists
EP0932405A4 (fr) * 1996-06-27 2001-10-17 Smithkline Beckman Corp Antagonistes des recepteurs d'il-8
DE69826695T2 (de) * 1997-05-23 2006-02-02 Bayer Pharmaceuticals Corp., West Haven Arylharnstoffderivate zur behandlung von inflammatorischen oder immunomodulatorischen erkrankungen

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PL348179A1 (en) 2002-05-06
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BG105661A (en) 2002-02-28
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EP1161232A1 (fr) 2001-12-12
NZ511993A (en) 2003-12-19
OA11731A (en) 2005-05-12
AU3123700A (en) 2000-07-03
CZ20012150A3 (cs) 2001-11-14
HK1043535A1 (en) 2002-09-20
HUP0104686A3 (en) 2005-06-28
DZ2964A1 (fr) 2004-03-15
AU748799B2 (en) 2002-06-13
TR200101772T2 (tr) 2002-04-22
MA25366A1 (fr) 2002-04-01
PE20001323A1 (es) 2001-01-07
ATE262328T1 (de) 2004-04-15
WO2000035442A1 (fr) 2000-06-22
DK1161232T3 (da) 2004-07-26
NO20012948D0 (no) 2001-06-14
DE69915888T2 (de) 2005-01-13
KR20010101243A (ko) 2001-11-14
JP2002532419A (ja) 2002-10-02
EA005210B1 (ru) 2004-12-30
HUP0104686A2 (hu) 2002-04-29
HK1043535B (en) 2005-01-07
EA200100659A1 (ru) 2001-12-24
CA2355890A1 (fr) 2000-06-22
IL143507A0 (en) 2002-04-21
US6500863B1 (en) 2002-12-31
DE69915888D1 (de) 2004-04-29
UY25842A1 (es) 2001-04-30
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