PT1185498E - Sintese de acido ciclo-hexilfenilglcolico opticamente activo e dos seus esteres - Google Patents

Sintese de acido ciclo-hexilfenilglcolico opticamente activo e dos seus esteres

Info

Publication number
PT1185498E
PT1185498E PT99953250T PT99953250T PT1185498E PT 1185498 E PT1185498 E PT 1185498E PT 99953250 T PT99953250 T PT 99953250T PT 99953250 T PT99953250 T PT 99953250T PT 1185498 E PT1185498 E PT 1185498E
Authority
PT
Portugal
Prior art keywords
cyclohexylpenylglcolic
esters
synthesis
acid
optically active
Prior art date
Application number
PT99953250T
Other languages
English (en)
Inventor
Chris Hugh Senanayake
Francis X Mc Conville
Roger P Bakale
Jorge L Lopez
Charles P Vandenbossche
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/177,456 external-priority patent/US5973182A/en
Application filed by Sepracor Inc filed Critical Sepracor Inc
Publication of PT1185498E publication Critical patent/PT1185498E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96—Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/12—Preparation of carboxylic acid esters from asymmetrical anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/02—Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PT99953250T 1998-10-22 1999-10-22 Sintese de acido ciclo-hexilfenilglcolico opticamente activo e dos seus esteres PT1185498E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/177,456 US5973182A (en) 1998-10-22 1998-10-22 Carbonate Intermediates useful in the preparation of optically active cyclohexylphenylglycolate esters
US09/211,646 US6140529A (en) 1998-10-22 1998-12-15 Synthesis of optically active cyclohexylphenylglycolate esters

Publications (1)

Publication Number Publication Date
PT1185498E true PT1185498E (pt) 2004-06-30

Family

ID=26873314

Family Applications (2)

Application Number Title Priority Date Filing Date
PT99953250T PT1185498E (pt) 1998-10-22 1999-10-22 Sintese de acido ciclo-hexilfenilglcolico opticamente activo e dos seus esteres
PT03104950T PT1424321E (pt) 1998-10-22 1999-10-22 Sintese de esteres de ciclo-hexilfenilglicolato opticamente activos

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT03104950T PT1424321E (pt) 1998-10-22 1999-10-22 Sintese de esteres de ciclo-hexilfenilglicolato opticamente activos

Country Status (11)

Country Link
US (1) US6140529A (pt)
EP (3) EP1185498B1 (pt)
JP (1) JP2002527500A (pt)
AT (2) ATE332290T1 (pt)
AU (2) AU766066B2 (pt)
CA (1) CA2347736A1 (pt)
DE (2) DE69932269T2 (pt)
DK (2) DK1424321T3 (pt)
ES (2) ES2215406T3 (pt)
PT (2) PT1185498E (pt)
WO (1) WO2000023414A2 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180823B1 (en) * 1998-11-06 2001-01-30 Sepracor Inc. Stereoselective process for alkyl phenylglycolic acids
CA2361156A1 (en) * 2000-11-07 2002-05-07 Sumika Fine Chemicals Co., Ltd. Production method of 2-cyclohexyl-2-hydroxy-2-phenylacetic acid, intermediate therefor and production method thereof
US6825378B2 (en) * 2003-03-28 2004-11-30 Council Of Scientific And Industrial Research Process for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid
CN103012231B (zh) * 2012-12-14 2015-08-05 沈阳药科大学 格隆溴铵手性对映体的制备方法和应用
CN103772188B (zh) * 2014-02-25 2015-09-23 成都百事兴科技实业有限公司 R-(+)-α-环己基扁桃酸的制备方法
EP4146621A1 (en) 2020-05-05 2023-03-15 Apnimed, Inc. (Delaware) Polymorphic forms of (r)-oxybutynin hydrochloride
WO2023214426A1 (en) * 2022-05-05 2023-11-09 Harman Finochem Limited Process for the preparation of r-oxybutynin hydrochloride

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB708370A (en) * 1950-12-27 1954-05-05 Albert Boehringer Process for the production of scopolamine-bromobutylate
GB750156A (en) * 1953-03-23 1956-06-13 Wellcome Found Improvements in cyclohexyl-phenyl-amino-propanols
US2837525A (en) * 1955-07-12 1958-06-03 Sterling Drug Inc 1-thienyl-1-cycloalkyl (or aryl)-3-(aliphatic-tertiary-amino)-1-hydroxy-lower-alkanes and preparation thereof
NL124473C (pt) * 1960-07-26
JP2651411B2 (ja) * 1988-06-13 1997-09-10 日本ヘキスト・マリオン・ルセル株式会社 アルキルアミノアセチレングリコール酸エステルの製法
IL91377A (en) * 1988-09-14 1996-09-12 Nippon Shinyaku Co Ltd Derivatives of botinylamine glycolate
NZ333257A (en) * 1996-07-01 2000-08-25 Bridge Pharma Inc Substituted cyclohexyl-phenyl-glycolates as spasmolytic agents

Also Published As

Publication number Publication date
AU6522299A (en) 2000-05-08
JP2002527500A (ja) 2002-08-27
WO2000023414A2 (en) 2000-04-27
EP1642883A3 (en) 2006-05-03
AU2003271292A2 (en) 2004-01-29
AU2003271292A1 (en) 2004-01-29
ES2266726T3 (es) 2007-03-01
DK1424321T3 (da) 2006-07-31
EP1185498A2 (en) 2002-03-13
EP1642883A2 (en) 2006-04-05
DK1185498T3 (da) 2004-07-26
AU766066B2 (en) 2003-10-09
ES2215406T3 (es) 2004-10-01
WO2000023414A3 (en) 2001-12-13
DE69932269D1 (de) 2006-08-17
ATE263134T1 (de) 2004-04-15
DE69932269T2 (de) 2006-11-23
DE69916134T2 (de) 2005-02-03
DE69916134D1 (de) 2004-05-06
US6140529A (en) 2000-10-31
CA2347736A1 (en) 2000-04-27
PT1424321E (pt) 2006-09-29
EP1185498B1 (en) 2004-03-31
ATE332290T1 (de) 2006-07-15
EP1424321B1 (en) 2006-07-05
EP1424321A1 (en) 2004-06-02

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