PT1242603E - Vectores e processo para a producao de proteinas recombinantes em fungos - Google Patents

Vectores e processo para a producao de proteinas recombinantes em fungos

Info

Publication number
PT1242603E
PT1242603E PT00985088T PT00985088T PT1242603E PT 1242603 E PT1242603 E PT 1242603E PT 00985088 T PT00985088 T PT 00985088T PT 00985088 T PT00985088 T PT 00985088T PT 1242603 E PT1242603 E PT 1242603E
Authority
PT
Portugal
Prior art keywords
host organism
vectors
integration
heterologous
proteins
Prior art date
Application number
PT00985088T
Other languages
English (en)
Inventor
Cornelis P Hollenberg
Gerd Gellissen
Andre Diesel
Jens Klabunde
Manfred Suckow
Original Assignee
Rhein Biotech G Fur Neue Biote
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19963690A external-priority patent/DE19963690A1/de
Application filed by Rhein Biotech G Fur Neue Biote filed Critical Rhein Biotech G Fur Neue Biote
Publication of PT1242603E publication Critical patent/PT1242603E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
PT00985088T 1999-11-23 2000-11-23 Vectores e processo para a producao de proteinas recombinantes em fungos PT1242603E (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19956297 1999-11-23
DE19958327 1999-12-03
DE19963690A DE19963690A1 (de) 1999-11-23 1999-12-29 Vektoren und Verfahren zur Herstellung rekombinanter Proteine in Pilzen

Publications (1)

Publication Number Publication Date
PT1242603E true PT1242603E (pt) 2004-09-30

Family

ID=27219346

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00985088T PT1242603E (pt) 1999-11-23 2000-11-23 Vectores e processo para a producao de proteinas recombinantes em fungos

Country Status (7)

Country Link
EP (1) EP1242603B1 (pt)
AT (1) ATE264917T1 (pt)
AU (1) AU2162101A (pt)
DK (1) DK1242603T3 (pt)
ES (1) ES2221865T3 (pt)
PT (1) PT1242603E (pt)
WO (1) WO2001038510A2 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002053758A2 (de) * 2000-12-29 2002-07-11 Rhein Biotech Gesellschaft für neue Biotechnologische Prozesse und Produkte mbH Verfahren zum herstellen von heterologen proteinen in einem homothallischen pilz der familie sordariaceae
ITMI20011728A1 (it) * 2001-08-06 2003-02-06 Consorzio Per Le Ricerche E Lo Vettore per l'integrazione sito-specifica di sequenze di dna eterologhe in lieviti metilotrofi
EP1698702B1 (en) * 2005-03-02 2012-02-22 PharmedArtis GmbH Recombinant protein expression system
HUE050997T2 (hu) * 2008-05-06 2021-03-01 Archer Daniels Midland Co Keményítõ- és xilánbontó enzimek expresszálásával keményítõ és xilán alkoholos fermentációjára képes hõtûrõ Hansenula polymorpha élesztõtörzsek kifejlesztése
US10457949B2 (en) * 2014-08-21 2019-10-29 Chung-Ang University Industry-Academy Cooperation Foundation rDNA NTS-based gene multiple insertion cassette set and GRAS-grade recombinant yeast strain

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999057279A1 (en) * 1998-05-07 1999-11-11 Doosan Corporation Plasmid for gene expression in pichia ciferrii and transformation method using the same

Also Published As

Publication number Publication date
WO2001038510A3 (de) 2002-07-04
AU2162101A (en) 2001-06-04
ES2221865T3 (es) 2005-01-16
DK1242603T3 (da) 2004-06-28
WO2001038510A2 (de) 2001-05-31
ATE264917T1 (de) 2004-05-15
EP1242603B1 (de) 2004-04-21
EP1242603A2 (de) 2002-09-25

Similar Documents

Publication Publication Date Title
Gustafsson et al. Codon bias and heterologous protein expression
WO2001079507A3 (en) EXPRESSION-REGULATING SEQUENCES AND EXPRESSION PRODUCTS IN THE FIELD OF FILAMENTOUS FUNGI $i(CHRYSOSPORIUM)
EP1321523A3 (en) Selection marker gene free recombinant strains; a method for obtaining them and the use of these strains
EP2325319A3 (en) Product and process for transformation of Thraustochytriales microorganisms
DE69534733D1 (de) NEUARTIGE AUF p53 ANSPRECHENDE GENE
PT1242603E (pt) Vectores e processo para a producao de proteinas recombinantes em fungos
WO2003031928A3 (en) Cellular engineering, protein expression profiling, differential labeling of peptides, and novel reagents therefor
ATE480624T1 (de) Yapsin-mangelmutantenstamm von hansenula polymorpha sowie verfahren zur herstellung rekombinanter proteine damit
WO2000004167A3 (en) Genes encoding sulfate assimilation proteins
EP1576095A4 (en) CANDIDA TROPLICALIS / I ALCOHOLIC ALCOHOL OXIDASE GENES AND PROTEINS AND METHODS THEREOF
ID22037A (id) PROSES REKOMBINAN UNTUK MEMBUAT ANTIGEN MALARIA KOMPLET gp190/MSPI
ATE233820T1 (de) Promotor/terminator des formatdehydrogenase-gens von candida boidinii
TW200502388A (en) Expression vector, methods for the production of heterologous gene products and for the selection of recombinant cells producing high levels of such products
Boldogköi et al. G and C accumulation at silent positions of codons produces additional ORFs
WO2002081650A3 (en) Alcohol oxidase 1 regulatory nucleotide sequences for heterologous gene expression in yeast
WO2002081702A1 (fr) Genes de desaturase en position $g(d)6 d'acide gras, plasmides et transformants contenant ces genes
EP1316612A4 (en) LACRYMOGENIC COMPONENT SYNTHASE ISOZYMES AND GENE ENCODING THE SAME
WO2002057412A3 (en) Plant promoters, and methods of use
DE59901930D1 (de) Expressionssystem zur produktion von proteinen
NO331102B1 (no) Promotor, ekspresjonsvektor og vert, og fremgangsmate for a produsere et aktuelt protein
WO2004016756A3 (en) Promoter motifs in candida tropicalis
RU2001124653A (ru) Новая трансформационная система для экспрессии генов грибов под контролем регуляторных систем мицелиального гриба Penicillium canescnes
KR950003446A (ko) 돌연변이체 aox2 프로모터, 이를 보유한 벡터, 형질 전환체, 및 이종 단백질의 제조방법
MX9702889A (es) Mejoramiento de un vector de expresion para la produccion de proteinas recombinantes.
MX9709380A (es) Acidos nucleicos virales recombinantes.